MORE THAN THE TONE: THE IMPACT OF SOCIAL MEDIA OPINIONS ON INNOVATION INVESTMENTS

Social media is a valuable knowledge source for firm innovation. Extending the literature of both social media and innovation management, we attempt to examine how the valence and volume of user-generated content (UGC) from social media influence firm organizational innovation behav-iours. In this research-in-progress study, we have reviewed the existing literatures and proposed three hypotheses. Firstly, we propose that valence of UGC from social media has a U-shaped rela-tion with firm innovation investments. In particular, compared with neutral UGC, both negative and positive contents are found to push firms to invest more in innovation. Secondly, we argued that such a curvilinear relation is mitigated with an increase in volume of UGC. Last but not least, we argued that firm investment in innovation improves firm performance. To validate our pro-posed hypotheses, we have designed an innovative framework of sentiment analysis and collected a large dataset including 5-year panel with 886 listed firms and their relevant 6.2 million micro-blogs. The preliminary results from applying sentiment analysis into the collected dataset are re-ported in this study. In the future, we will validate our hypotheses with more sophisticated estima-tion models and strict robustness check. The potential contribution to theory and practice is also discussed

Clinical application of minimal invasive arthroscope on patella fracture surgery

The aim of the research is to perform the application of minimal invasive arthroscope on patella fracture surgery. A total of 100 patients with the cases of patella fracture were selected from our hospital and the Second Xiangya Hospital’s Orthopaedic Ward. These patients were divided into ‘Observation Group’ and ‘Comparison Group’. The ‘Comparison Group’ was treated using traditional open surgery whereas the ‘Observation Group’ used the arthroscopic surgery. The postsurgical score by both groups showed that there are statistical significance differences in Lysholm Knee Pain Scale (P < 0.05) and Oswestry Low Back Pain Scale (P < 0.05). By performing arthroscopic surgery on patella fractures, the patients’ recovery capabilities enhanced while the pain was greatly reduced, which in turn, has improved the quality of patients’ life and provide valuable clinical value

Comparative analysis of phosphoproteomic in the intestine of Sepia lycidas under different salinity environments

Cuttlefish are sensitive to the breeding environment, and the low-salinity environment significantly impacts their growth and immunity. So far, it is difficult to breed this species artificially. This study was conducted in Sepia lycidas. And the aim was to investigate the differences in protein phosphorylation in the intestine of S. lycidas under different salinity conditions. Firstly, 999 phosphoproteins (specific peptide ≥ 1), 1928 phosphopeptides, and 2727 phosphorylation sites were identified. Among them were 284 down-regulated expression phosphorylation sites (corresponding to 115 phosphoproteins) and 674 up-regulated expression phosphorylation sites (corresponding to 408 phosphoproteins) in the intestine under a low salinity environment compared with that under a natural salinity environment. Next, GO analysis found that more phosphoproteins corresponding to differentially expressed phosphorylation sites were related to anatomical structure development, multicellular organism development, regulation of the cellular process, etc. The molecular functions of these proteins mainly contain protein binding, transferase activity, catalytic activity, and heterocyclic compound binding. And they are mainly involved in the cellular components of intracellular anatomical structure, organelle, and cytoplasm. KEGG enrichment analysis of the differential phosphoproteins suggested that many significantly enriched pathways were related to the phosphatidylinositol signaling system, cell junction (adherens junction and tight junction), and inositol phosphate metabolism. Finally, changes in environmental salinity can affect the intestinal structure, metabolism, and immune homeostasis of S. lycidas

The fabrication and properties of magnetorheological elastomers employing bio-inspired dopamine modified carbonyl iron particles

To obtain magnetorheological elastomers (MREs) with improved mechanical properties and exhibiting an enhanced magnetorheological (MR) effect, bio-inspired dopamine modification has been used to improve the functionality at the surface of carbonyl iron (CI) particles. Various techniques including x-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to confirm that a polydopamine (PDA) layer of about 27.5 nm had been successfully deposited on the surface of the carbonyl iron particles prior to their inclusion in the MRE composites. The magnetic properties of PDA modified CI particles were shown to be almost the same as those for untreated CI particles. With the introduction of a PDA layer to the surfaces of the particles, both the tensile strength and the elongation at break of the MREs were improved. Furthermore, the MRE composites filled with PDA-coated CI particles exhibited lower zero-field storage moduli but higher magnetic field induced storage moduli when magnetization saturation was reached. The absolute and relative MR effect for the MREs reached 0.68 ± 0.002 MPa and 294% respectively, which were higher than those of MREs with pristine CI particles whose absolute and relative MR effect were 0.57 ± 0.02 MPa and 187% respectively. The findings of this work provide insights into enhanced fabrication of MREs with both improved mechanical properties and magneto-induced performance

Styrene-ethylene-butadiene-styrene copolymer/carbon nanotubes composite fiber based strain sensor with wide sensing range and high linearity for human motion detection

Flexible strain sensors have attracted extensive attention due to their potential applications in wearable electronics and health monitoring. However, it is still a challenge to obtain flexible strain sensors with both high stretchability and wide linear strain sensing range. In this study, styrene-ethylene-butadiene-styrene copolymer/carbon nanotubes (SEBS/CNTs) composite fiber which showed both electrical conductivity and high stretchability was fabricated through a scalable wet spinning method. The effect of CNTs content on the strain sensing behavior of the SEBS/CNTs fiber based strain sensor was investigated. The results showed that when the CNTs content reached 7 wt%, the SEBS/CNTs composite fiber was capable of sensing strains as high as 500.20% and showed a wide linear strain sensing range of 0-500.2% with a gauge factor (GF) of 38.57. Combining high stretchability, high linearity and reliable stability, the SEBS/CNTs composite fiber based strain sensor had the ability to monitor the activities of different human body parts including hand, wrist, elbow, shoulder and knee

Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways.

Granulosa cell tumors (GCTs) are the most common ovarian estrogen producing tumors, leading to symptoms of excessive estrogen such as endometrial hyperplasia and endometrial adenocarcinoma. These tumors have malignant potential and often recur. The etiology of GCT is unknown. TGFα is a potent mitogen for many different cells. However, its function in GCT initiation, progression and metastasis has not been determined. The present study aims to determine whether TGFα plays a role in the growth of GCT cells. KGN cells, which are derived from an invasive GCT and have many features of normal granulosa cells, were used as the cellular model. Immunohistochemistry, Western blot and RT-PCR results showed that the ErbB family of receptors is expressed in human GCT tissues and GCT cell lines. RT-PCR results also indicated that TGFα and EGF are expressed in the human granulosa cells and the GCT cell lines, suggesting that TGFα might regulate GCT cell function in an autocrine/paracrine manner. TGFα stimulated KGN cell DNA synthesis, cell proliferation, cell viability, cell cycle progression, and cell migration. TGFα rapidly activated EGFR/PI3K/Akt and mTOR pathways, as indicated by rapid phosphorylation of Akt, TSC2, Rictor, mTOR, P70S6K and S6 proteins following TGFα treatment. TGFα also rapidly activated the EGFR/MEK/ERK pathway, and P38 MAPK pathways, as indicated by the rapid phosphorylation of EGFR, MEK, ERK1/2, P38, and CREB after TGFα treatment. Whereas TGFα triggered a transient activation of Akt, it induced a sustained activation of ERK1/2 in KGN cells. Long-term treatment of KGN cells with TGFα resulted in a significant increase in cyclin D2 and a decrease in p27/Kip1, two critical regulators of granulosa cell proliferation and granulosa cell tumorigenesis. In conclusion, TGFα, via multiple signaling pathways, regulates KGN cell proliferation and migration and may play an important role in the growth and metastasis of GCTs