The distribution of targets of “core” pluripotency TFs in mouse BioGRID.

<p>(A) miRNA targets obtained from miRecords. (B) Targets of miRNAs from TarBase.</p

Sílabo de Derecho Laboral

La asignatura es un curso formativo para el estudiante de contabilidad necesariamente vinculado a la empresa o a personas naturales con negocios donde se desarrollan relaciones laborales y por lo tanto se generan derechos y obligaciones para los empleadores y trabajadores. El curso es de naturaleza teórica – práctica y tiene por objeto dotar al estudiante de los conocimientos que le permitan liquidar los beneficios sociales y demás derechos laborales a fin de cumplir de manera eficiente su actividad profesional

Mouse PPIN topological properties of TF-targets vs NON-TF-targets.

<p>Mouse PPIN topological properties of TF-targets vs NON-TF-targets.</p

Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks

<div><p>The molecular mechanism that maintains the pluripotency of embryonic stem cells (ESCs) is not well understood but may be reflected in complex biological networks. However, there have been few studies on the effects of transcriptional and post-transcriptional regulation during the development of ESCs from the perspective of computational systems biology. In this study, we analyzed the topological properties of the “core” pluripotency transcription factors (TFs) OCT4, SOX2 and NANOG in protein-protein interaction networks (PPINs). Further, we identified synergistic interactions between these TFs and microRNAs (miRNAs) in PPINs during ESC development. Results show that there were significant differences in centrality characters between TF-targets and non-TF-targets in PPINs. We also found that there was consistent regulation of multiple “core” pluripotency TFs. Based on the analysis of shortest path length, we found that the module properties were not only within the targets regulated by common or multiple “core” pluripotency TFs but also between the groups of targets regulated by different TFs. Finally, we identified synergistic regulation of these TFs and miRNAs. In summary, the synergistic effects of “core” pluripotency TFs and miRNAs were analyzed using computational methods in both human and mouse PPINs.</p></div

Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.

<p>Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.</p

Tobler / Beglinger-Brevier zum Institutionellen Abkommen Schweiz-EU

Die Schweiz und die Europäische Union (EU) verhandeln seit dem Frühling 2014 über ein institutionelles Abkommen“ zu wichtigen Teilen des bilateralen Rechts. Man spricht auch von den „institutionellen Fragen“, einem „institutionellen Rahmenabkommen“ und neuerdings – seit dem Juni 2017 – einem „Konsolidierungsabkommen“. Das Thema erscheint regelmässig in den Medien und ist z.T. stark umstritten. Dementsprechend unterschiedlich wird die Sachlage dargestellt – mit der Folge, dass unklar bleibt, worum es denn eigentlich genau geht. Das vorliegende Brevier versucht, wichtige, immer wiederkehrende Diskussionspunkte zu klären und so zum besseren Verständnis der komplexen Thematik beizutragen.

Venn diagram showing the targets of “core” pluripotency TFs.

<p>(A) Human targets of TFs. (B) Mouse targets of TFs.</p

Definitions of the topological properties.

<p>Definitions of the topological properties.</p

Function categories analysis about targets of NANOG and miRNAs in PIR.

<p>Function categories analysis about targets of NANOG and miRNAs in PIR.</p

The distribution of targets of “core” pluripotency TFs in HPRD.

<p>(A) miRNA targets obtained from miRecords. (B) Targets of miRNAs from TarBase.</p