Changes in numbers and distribution of breeding waterfowl in the Swedish mountain chain between 1972–1975 and 2009

During 1972–1975, the breeding waterfowl populations of the northern parts of Fennoscandia (south to 65° N in Sweden) were surveyed for the first time. In 2009, a new survey was undertaken in the Swedish part of the mountain chain. Censuses were performed from the air in transects of 5×5 km squares and in special areas. The distribution of the different species was largely similar between the two periods but there were a number of differences on the regional level. Most species had more or less the same population sizes but there were some variation in the different parts of the mountains. Three species showed clear increases between the periods. Cygnus cygnus had the same increase in the mountain chain as in the rest of the country. Melanitta nigra was about four times as common in 2009 compared to the 1970s and Mergus merganser also had higher counts in 2009. Melanitta fusca decrease

Overcoming migration during giant planet formation

In the core accretion model, gas giant formation is a race between growth and migration; for a core to become a jovian planet, it must accrete its envelope before it spirals into the host star. We use a multizone numerical model to extend our previous investigation of the "window of opportunity" for gas giant formation within a disk. When the collision cross-section enhancement due to core atmospheres is taken into account, we find that a broad range of protoplanetary disks posses such a window.Comment: 4 pages, 3 figs, accepted to ApJ

Ortnamnsvård i FN

I diskussionen efter ett par av föredragen vid det nordiska språkmötet i Uppsala2007 informerade jag kort om FN:s arbete med ortnamn. I denna artikel ges ennågot utförligare presentation. Framför allt behandlas den verksamhet som rörhanteringen av utländska namn – exonymer och överföring av ortnamn till latinsktalfabet (”romanization”) – och vilken roll FN:s resolutioner spelar i dettasammanhang

Role of the FOXC2 -512C>T polymorphism in type 2 diabetes: possible association with the dysmetabolic syndrome.

OBJECTIVE: Overexpression of the human transcription factor FOXC2 gene ( FOXC2) protects against insulin resistance in mice and a common FOXC2 polymorphism (-512C > T) has been suggested to be associated with insulin resistance in humans. Here, we addressed the potential role for FOXC2 as a candidate gene for type 2 diabetes and associated phenotypes. MATERIALS AND METHODS: A case-control study was performed in 390 type 2 diabetic patients and 307 control subjects. The number of patients was increased to a total of 768 subjects for further study of phenotypic differences relating to the dysmetabolic syndrome relative to genetic variation. The FOXC2 -512C > T polymorphism was genotyped by a restriction fragment length polymorphism PCR assay. RESULTS: FOXC2 -512C > T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects, but the C/C genotype was associated with increased body mass index (BMI, kg/m(2)) (P-a = 0.03) among type 2 diabetic patients. The FOXC2 -512C > T polymorphism was a significant independent predictor of BMI (P = 0.001) in a multiple regression model including age, gender and affection status. We found no significant association with type 2 diabetes-related metabolic parameters but that the C-allele (P = 0.01) and C/C and C/T genotypes (P = 0.03) were significantly over-represented in type 2 diabetic males with a concomitant diagnosis of dysmetabolic syndrome. CONCLUSION: We conclude that FOXC2 is associated with obesity and metabolic deterioration but does not contribute to an increased risk for type 2 diabetes

Sialosyllactotetraosylceramide, a novel ganglioside antigen detected in human carcinomas by a monoclonal antibody

AbstractA novel ganglioside was detected in a small cell lung carcinoma by TLC-immunostaining of gangliosides with a monoclonal antibody, the C-50 MAb. Structural characterization showed this ganglioside to be IV3NeuAc-LcOse4Cer, a hitherto unknown ganglioside. This ganglioside has also been detected as a minor component in many different carcinomas using the C-50 MAb. The normally dominant CA-50 ganglioside antigen is IV3NeuAc. III4Fuc-LcOse4Cer. Based upon solid-phase binding to IV3NeuAc, III4-LcOse4Cer and IV3NeuAc-LcOse4Cer it is concluded that the C-50 MAb recognizes an epitope present in sialylated type I carbohydrate chains

Adult-onset diabetes in Middle Eastern immigrants to Sweden : Novel subgroups and diabetic complications-The All New Diabetes in Scania cohort diabetic complications and ethnicity

Background Middle Eastern immigrants to Europe represent a high risk population for type 2 diabetes. We compared prevalence of novel subgroups and assessed risk of diabetic macro- and microvascular complications between diabetes patients of Middle Eastern and European origin. Methods This study included newly diagnosed diabetes patients born in Sweden (N = 10641) or Iraq (N = 286), previously included in the All New Diabetes in Scania cohort. The study was conducted between January 2008 and August 2016. Patients were followed to April 2017. Incidence rates in diabetic macro- and microvascular complications were assessed using cox-regression adjusting for the confounding effect of age at onset, sex, anthropometrics, glomerular filtration rate (eGFR) and HbA1c. Findings In Iraqi immigrants versus native Swedes, severe insulin-deficient diabetes was almost twice as common (27.9 vs. 16.2% p <0.001) but severe insulin-resistant diabetes was less prevalent. Patients born in Iraq had higher risk of coronary events (hazard ratio [HR] 1.84, 95% CI 1.06-3.12) but considerably lower risk of chronic kidney disease (CKD) than Swedes (HR 0.19; 0.05-0.76). The lower risk in Iraqi immigrants was partially attributed to better eGFR. Genetic risk scores (GRS) showed more genetic variants associated with poor insulin secretion but lower risk of insulin resistance in the Iraqi than native Swedish group. Interpretation People with diabetes, born in the Middle East present with a more insulin-deficient phenotype and genotype than native Swedes. They have a higher risk of coronary events but lower risk of CKD. Ethnic differences should be considered in the preventive work towards diabetes and its complications.Peer reviewe