The Valve Timing Optimization of the Diesel Engine Based on Response Surface Methodology

To study the effect of valve timing on the diesel engine performance, the simulation model of diesel engine was established with AVL BOOST and its accuracy was proved. The volumetric efficiency is one of the important indicators to evaluate engine performance. The volumetric efficiency as optimization objective and valve timing were optimized and discussed by using Box-Behnken test method and the response surface methodology. Optimization result shows that volumetric efficiency of the diesel engine can been increased by 6.42% under rated speed

Research of the Vehicle Load Control System Integration Device

With the gradual development of economy, the scale of transportation industry continues to expand. The problem of overload or overrun in the vehicle transport has emerged. Therefore, how simply and conveniently to know the vehicle load and how to effectively limit overload has become a key issue. This paper demonstrates the feasibility of vehicle load control system from the above problems. Through the pressure sensors installed in the vehicle suspension, the single-chip microprocessor receives the information transmitted by the pressure sensors, and calculates the total weight of the vehicle load; if overweight, the single-chip microprocessor will send commands to the ignition system, to stop the ignition system working. Its purpose is to improve vehicle safety and effectively reduce heavy workload of the vehicle detection station to improve their work efficiency

Evaluation of anti-fatigue property of Porphyridium cruentum in mice

Purpose: To evaluate the potential effects of Porphyridium cruentum (PC) on fatigue induced by forced swimming test in mice. Methods: Mice were randomly divided into normal control group (NC, i.e., untreated non-swimming); model control group (MC, untreated swimming); Spirulina treated group (SP, 800 mg/kg); PC-treated groups (50, 100, and 200 mg/kg), respectively. After intragastric administration for 14 consecutive days, a weight-bearing swimming experiment was conducted for the mice, and the biochemical indicators related to fatigue were examined, including exhaustive swimming time, glucose levels (Glu), hepatic glycogen contents (HG), muscle glycogen contents (MG), glutathione peroxidase activities (GSH-Px), creatine kinase (CK), malondialdehyde (MDA), urea nitrogen levels (SUN), lactate dehydrogenase activities (LDH), lactic acid (LA) as well as superoxide dismutase (SOD). Results: PC significantly prolonged the swimming endurance time compared to MC. After PC treatment, Glu, HG and MG were effectively increased dose-dependently, SUN, LA, LDH and CK levels in serum were significantly reduced. Moreover, PC treatment elevated the bioactivities of two antioxidant enzymes, namely, GSH-Px and SOD, while MDA content decreased when compared to MC group. Conclusion: These results indicate that PC exhibits strong anti-fatigue effect. Thus, PC may be suitable for incorporation in functional food to counter fatigue

Case report: A combined immunotherapy strategy as a promising therapy for MSI-H colorectal carcinomas with multiple HPD risk factors

Approximately 5% of advanced colorectal carcinomas (CRCs) and 12–15% of early CRCs are microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) tumors. Nowadays, PD-L1 inhibitors or combined CTLA4 inhibitors are the major strategies for advanced or metastatic MSI-H colorectal cancer, but some people still show drug resistance or progression. Combined immunotherapy has been shown to expand the benefit population in non-small-cell lung carcinoma (NSCLC), hepatocellular carcinoma (HCC), and other tumors while reducing the incidence of hyper-progression disease (HPD). Nevertheless, advanced CRC with MSI-H remains rare. In this article, we describe a case of an elder patient with MSI-H advanced CRC carrying MDM4 amplification and DNMT3A co-mutation who responded to sintilimab plus bevacizumab and chemotherapy as the first-line treatment without obvious immune-related toxicity. Our case provides a new treatment option for MSI-H CRC with multiple risk factors of HPD and highlights the importance of predictive biomarkers in personalized immunotherapy

Influence of Bearing Stiffness on the Nonlinear Dynamics of a Shaft-Final Drive System

The bearing stiffness has a considerable influence on the nonlinear coupling vibration characteristics of the shaft-final drive system. A 14-DOF nonlinear coupled vibration model was established by employing the lumped mass method so as to identify the coupling effects of the bearing stiffness to the vibration response of the shaft-final drive system. The engine’s torque ripple, the alternating load from the universal joint (U-joint), and the time-varying mesh parameters of hypoid gear of the shaft-final drive system were also considered for accurate quantitative analysis. The numerical analysis of the vibration response of the coupled system was performed and the experimental measurements were carried out for the validation test. Results show that, at the given driving speed, improving the bearing stiffness can reduce the vibration response of the given coupled system; however, when the bearing stiffness increases to a critical value, the effects of bearing stiffness on the vibration reduction become insignificant; when the driving speed changes, the resonance regions of the coupled system vary with the bearing stiffness. The results are helpful to determine the proper bearing stiffness and the optimum control strategy for the shaft-final drive system. It is hoped that the optimal shaft-final drive system can provide good vibration characteristics to achieve the energy saving and noise reduction for the vehicle application

Automatic Measurement of Inclination Angle of Utility Poles Using 2D Image and 3D Point Cloud

The utility pole inclination angle is an important parameter for determining pole health conditions. Without depth information, the angle cannot be estimated from a 2D image, and without large labeled reference pole data, it is time consuming to locate the pole in the 3D point cloud. Therefore, this paper proposes a method that processes the pole data from the 2D image and 3D point cloud to automatically measure the pole inclination angle. Firstly, the mask of the pole skeleton is obtained from an improved Mask R-CNN. Secondly, the pole point cloud is extracted from a PointNet that deals with the generated frustum from the pole skeleton mask and depth map fusion. Finally, the angle is calculated by fitting the central axis of the pole cloud data. ApolloSpace open dataset and laboratory data are used for evaluation. The experimental results show that the AP75 of improved Mask R-CNN is 58.15%, the accuracy of PointNet is 92.4%, the average error of pole inclination is 0.66°, and the variance is 0.12°. It is proved that the method can effectively realize the automatic measurement of pole inclination

Using pyridine as nitrogen-rich precursor to synthesize Co-N-S/C non-noble metal electrocatalysts for oxygen reduction reaction

The development of non-noble metal catalysts is of great interest due to their significant potential application in both fuel cell systems and metal\u2013air batteries, particularly when considering long term commercial deployment. In this regard, novel Co-N-S/C non-noble metal catalysts supported on carbon, are synthesized in this study using a solvent-milling method followed by heat-treatment at elevated temperatures. Pyridine is used as the nitrogen-rich ligand for Co-Nx precursor complex formation. The morphology and composition of the catalyst are characterized by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, transmission electron microscopy (TEM) as well as X-ray photoelectron spectroscopy (XPS). Several catalysts containing different amounts of Co are also synthesized. The optimal Co content is found to be in the range of 10\u201315 wt% nominal, in terms of catalytic oxygen reduction reaction (ORR) activity. This catalyst shows high electroactivity for the ORR with a high stability in alkaline media. Using rotating disk electrode measurements, and Koutechy\u2013Levich analysis, the overall electron transfer number in the catalyzed ORR is found to be 3.8\u20134.0, suggesting the catalyzed ORR is a four-electron transfer process from O2 to H2O.Peer reviewed: YesNRC publication: Ye