576 research outputs found
Superfocusing, Biosensing and Modulation in Plasmonics
Plasmonics could bridge the gap between photonics and electronics at the nanoscale,
by allowing the realization of surface-plasmon-based circuits and plasmonic chips in the
future. To build up such devices, elementary components are required, such as a passive
plasmonic lens to focus free-space light to nanometre area and an active plasmonic modulator
or switch to control an optical response with an external signal (optical, thermal or
electrical). This thesis partially focuses on designing novel passive and active plasmonic
devices, with a specific emphasis on the understanding of the physical principles lying
behind these nanoscale optical phenomena.
Three passive plasmonic devices, designed by conformal transformation optics, are
numerically studied, including nanocrescents, kissing and overlapping nanowire dimers.
Contrary to conventional metal nanoparticles with just a few resonances, these devices
with structural singularities are able to harvest light over a broadband spectrum and focus
it into well-defined positions, with potential applications in high efficiency solar cells
and nanowire-based photodetectors and nanolasers. Moreover, thermo-optical and electrooptical
modulation of plasmon resonances are realized in metallic nanostructures integrated
with either a temperature-controlled phase transition material (vanadium dioxide,
VO2), or ferroelectric thin films.
Taking advantage of the high sensitivity of particle plasmon resonances to the change of
its surrounding environment, we develop a plasmon resonance nanospectroscopy technique
to study the effects of sizes and defects in the metal-insulator phase transition of VO2 at
the single-particle level, and even single-domain level. Finally, we propose and examine the
use of two-dimensional metallic nanohole arrays as a refractive index sensing platform for
future label-free biosensors with good surface sensitivity and high-throughput detection
ability.
The designed plasmonic devices have great potential implications for constructing nextgeneration
optical computers and chip-scale biosensors. The developed plasmon resonance
nanospectroscopy has the potential to probe the interfacial or domain boundary scattering
in polycrystalline and epitaxial thin films
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Doping-free complementary WSe2 circuit via van der Waals metal integration.
Two-dimensional (2D) semiconductors have attracted considerable attention for the development of ultra-thin body transistors. However, the polarity control of 2D transistors and the achievement of complementary logic functions remain critical challenges. Here, we report a doping-free strategy to modulate the polarity of WSe2 transistors using same contact metal but different integration methods. By applying low-energy van der Waals integration of Au electrodes, we observed robust and optimized p-type transistor behavior, which is in great contrast to the transistors fabricated on the same WSe2 flake using conventional deposited Au contacts with pronounced n-type characteristics. With the ability to switch majority carrier type and to achieve optimized contact for both electrons and holes, a doping-free logic inverter is demonstrated with higher voltage gain of 340, at the bias voltage of 5.5 V. Furthermore, the simple polarity control strategy is extended for realizing more complex logic functions such as NAND and NOR
Theoretical realization of an ultra-efficient thermal-energy harvesting cell made of natural materials
10.1039/c3ee41512kEnergy and Environmental Science6123537-354
A quasi real-time approach to investigating the damage and fracture process in plain concrete by X-ray tomography
In most concrete-related computer tomography (CT) experiments, detailed information on the damage and fracture process is obtained using nonreal-time approaches, with the CT method constantly regarded as a qualitative method. This study develops a quasi real-time method with the use of experimental instruments. The average CT number is used to analyse the damage and fracture process in concrete specimens and the theory that underlies concrete damage and fracture is improved. Various characteristics of the fracture form in different loading cases are investigated at the macro and micro levels. This study provides a convenient and fast method for qualitatively and quantitatively analysing concrete.
First published online: 01 Jun 201
HINT1 Is Involved in the Chronic Mild Stress Elicited Oxidative Stress and Apoptosis Through the PKC ε/ALDH-2/4HNE Pathway in Prefrontal Cortex of Rats
Major depressive disorder (MDD) is a severe, highly heterogeneous, and life-threatening psychiatric disease which affects up to 21% of the population worldwide. A new hypothesis suggests that the mitochondrial dysfunction causing oxidative stress (OS) and dysregulation of apoptosis in brain might be one of the key pathophysiological factors in MDD. Histidine triad nucleotide binding protein 1 (HINT1), which was first supposed to be protein kinase C (PKC) inhibitor, has been gradually demonstrated to be involved in diverse neuropsychiatric diseases. It still remains elusive that how HINT1 involves in depression. The present study utilized a rat model exposed to chronic mild stress (CMS) to explore the involvement of HINT1 in depression. Face validity, construct validity and predictive validity of CMS model were comprehensive evaluated in this study. Behavioral tests including sucrose preference test, open field test, and elevated plus maze and forced swimming test revealed that stressed rats displayed elevated level of anxiety and depression compared with the controls. CMS rats showed a significant decrease of superoxide dismutase, and a marked increase malondialdehyde levels in prefrontal cortex (PFC). We also found the CMS rats had elevated expression of HINT1, decreased levels of phosphorylated-PKC ε and aldehyde dehydrogenase-two (ALDH-2), and accumulated 4-hydroxynonenal (4HNE) in PFC. Moreover, CMS increased the levels of cleaved caspase-3 and Bax, and decreased the level of Bcl-2 in PFC. The alterations in behavior and molecule were prevented by antidepressant venlafaxine. These results demonstrated that HINT1 was involved in the CMS elicited OS and apoptosis in PFC, probably through the PKC ε/ALDH-2/4HNE pathway. The results suggest that the suppression of HINT1 might have potential as a novel therapeutic strategy for depression
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Possible Luttinger liquid behavior of edge transport in monolayer transition metal dichalcogenide crystals.
In atomically-thin two-dimensional (2D) semiconductors, the nonuniformity in current flow due to its edge states may alter and even dictate the charge transport properties of the entire device. However, the influence of the edge states on electrical transport in 2D materials has not been sufficiently explored to date. Here, we systematically quantify the edge state contribution to electrical transport in monolayer MoS2/WSe2 field-effect transistors, revealing that the charge transport at low temperature is dominated by the edge conduction with the nonlinear behavior. The metallic edge states are revealed by scanning probe microscopy, scanning Kelvin probe force microscopy and first-principle calculations. Further analyses demonstrate that the edge-state dominated nonlinear transport shows a universal power-law scaling relationship with both temperature and bias voltage, which can be well explained by the 1D Luttinger liquid theory. These findings demonstrate the Luttinger liquid behavior in 2D materials and offer important insights into designing 2D electronics
Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice
In recent years, the environmental impact of artificial light at night has been a rapidly growing global problem, affecting 99% of the population in the US and Europe, and 62% of the world population. The present study utilized a mouse model exposed to long-term artificial light and light deprivation to explore the impact of these conditions on emotion and cognition. Based on the potential links between histidine triad nucleotide binding protein 1 (HINT1) and mood disorders, we also examined the expression of HINT1 and related apoptosis factors in the suprachiasmatic nucleus (SCN), prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus (Hip). Mice exposed to constant light (CL) exhibited depressive- and anxiety-like behaviors, as well as impaired spatial memory, as demonstrated by an increased immobility time in the tail suspension and forced swimming tests, less entries and time spent in the open arms of elevated plus-maze, and less platform site crossings and time spent in the target quadrant in the Morris water maze (MWM). The effects of constant darkness (CD) partially coincided with long-term illumination, except that mice in the CD group failed to show anxiety-like behaviors. Furthermore, HINT1 was upregulated in four encephalic regions, indicating that HINT1 may be involved in mood disorders and cognitive impairments due to altered light exposure. The apoptosis-related proteins, BAX and BCL-2, showed the opposite expression pattern, reflecting an activated apoptotic pathway. These findings suggest that exposure to CL and/or darkness can induce significant changes in affective and cognitive responses, possibly through HINT1-induced activation of apoptotic pathways
Association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status: evidence from a cluster randomized controlled trial
Purpose
Evidence about the effect of maternal vitamin B12 supplementation on offspring’s vitamin B12 status is limited. The present interventional study sought to evaluate the association of antenatal vitamin B complex supplementation with neonatal vitamin B12 status.
Methods
In an ongoing cluster randomized controlled trial conducted in three rural counties in northwest China, pregnant women < 20 weeks of gestation were randomized to three treatment groups: blank control, iron supplements, or vitamin B complex supplements. All women were administered folic acid supplements during the periconceptional period. In a sub-study, we collected cord blood samples of 331 participants from the control or vitamin B complex groups in the Xunyi county from January 2017 to December 2017. Plasma concentrations of folate, vitamin B12, and homocysteine were measured. Linear mixed models with a random intercept for cluster were used to compare biochemical indexes between groups after controlling for covariates.
Results
Compared with newborns whose mothers were in the control group, newborns of the vitamin B complex-supplemented women had significantly higher cord plasma vitamin B12 (P = 0.001) and lower homocysteine concentrations (P = 0.043). The association of antenatal vitamin B complex supplementation with cord blood vitamin B12 concentrations appeared to be more pronounced among newborns with high folate status than those with low folate status (Pinteraction = 0.060).
Conclusions
Maternal vitamin B complex supplementation during pregnancy was associated with better neonatal vitamin B12 status in rural northwest China
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