The improvement of Pd nanoclusters electro-catalytic properties for FAO by the addition of Co element

Conference Name:2014 International Conference on Materials Science and Engineering Technology, MSET 2014. Conference Address: Shanghai, China. Time:June 28, 2014 - June 29, 2014.East China University of Science and Technology; Engineering and Industry Technology Institute; Shanghai JiaoTong University; Shanghai University of Engineering ScienceNear-monodisperse Pd and PdCo nanoclusters were synthesized by physical vapor deposition using a plasma-gas-condensation cluster deposition system and tested for catalyzing formic acid oxidation. Under the condition of high vacuum and inert gas, NCs with clean surface and uniform size were obtained. The cyclic voltammetry tests revealed that the electrochemical surface area was increased from 49.7 m2 g-1 to 51.7 m2 g-1 and the peak current density of catalyzing FAO was raised from 0.115 mA cm-2 to 0.125 mA cm-2 when about 12wt. % Co element was added. Additionally, the tolerance to CO poisoning of Pd could also be improved by the addition of Co. The result indicated that this method offered a chemical-free way to prepare clean and efficient Pd-based nanoscale catalytics and encouraged deeper exploration for electrochemichal catalytic reactions. ? (2014) Trans Tech Publications, Switzerland

Detection of polymorphisms and protein domain architectures in rabbit toll-like receptor 2

[EN] Toll-like receptors (TLRs) recognise pathogen-associated molecular patterns (PAMPs) derived from pathogens and participate in activation of the immune responses. The TLR2 gene can recognise PAMPs specific to bacterial diseases such as pneumonia. In the present study, we sequenced the coding regions of the TLR2 gene in 18 rabbits from 5 breeds, including New Zealand White, Californian, Flemish Giant, Chinchilla and Fu Jian Yellow. In total, we discovered 11 single nucleotide polymorphisms (SNPs), including 4 non-synonymous SNPs located within the predicted TLR domains. Two non-synonymous SNPs (G205A and G265C) were located in the LRR (leucine-rich repeat) domains of the predicted protein, while another non-synonymous SNP (C943T) was situated in the regions involved in binding to ligands. In addition, one synonymous SNP (C1174T) was distributed in the nucleus regions of heterodimers formed. Then, we revealed five conservative regions in the LRR patterning by prediction and comparison of TLR2 protein domain architectures for multiple species. The SNPs in the TLR2 gene may increase the probability of adaptation to variability of PAMPs due to the rapid evolution of pathogens and the possibility of survival in rabbit populations. The SNPs reported here will be useful to investigate the association between the TLR2 gene and disease resistance in future studies.This work was supported by funding from Sichuan Animal Science Academy and Applied Basic Research Programmes of the Science and Technology Foundation of Sichuan Province.Zhang, X.; Lei, M.; Xie, L.; Zhang, C.; Zheng, J.; Yang, C.; Deng, XD.... (2014). Detection of polymorphisms and protein domain architectures in rabbit toll-like receptor 2. World Rabbit Science. 22(1):83-90. doi:10.4995/wrs.2014.1457SWORD839022

Partial Wave Analysis of J/ψ→γ(K+K−π+π−)J/\psi \to \gamma (K^+K^-\pi^+\pi^-)

BES data on $J/\psi \to \gamma (K^+K^-\pi^+\pi^-)$ are presented. The $K^*\bar K^*$ contribution peaks strongly near threshold. It is fitted with a broad $0^{-+}$ resonance with mass $M = 1800 \pm 100$ MeV, width $\Gamma = 500 \pm 200$ MeV. A broad $2^{++}$ resonance peaking at 2020 MeV is also required with width $\sim 500$ MeV. There is further evidence for a $2^{-+}$ component peaking at 2.55 GeV. The non-$K^*\bar K^*$ contribution is close to phase space; it peaks at 2.6 GeV and is very different from $K^{*}\bar{K^{*}}$.Comment: 15 pages, 6 figures, 1 table, Submitted to PL

Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer

RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, ESR1 exons 1–6 were fused in frame to C-terminal sequences from the partner gene. Functional properties include estrogen-independent growth, constitutive expression of ER target genes, and anti-estrogen resistance. Both fusions activate a metastasis-associated transcriptional program, induce cellular motility, and promote the development of lung metastasis. ESR1-e6>YAP1- and ESR1-e6>PCDH11X-induced growth remained sensitive to a CDK4/6 inhibitor, and a patient-derived xenograft (PDX) naturally expressing the ESR1-e6>YAP1 fusion was also responsive. Transcriptionally active ESR1 fusions therefore trigger both endocrine therapy resistance and metastatic progression, explaining the association with fatal disease progression, although CDK4/6 inhibitor treatment is predicted to be effective. Lei et al. show that transcriptionally active estrogen receptor gene (ESR1) fusions identified from late-stage, treatment-refractory estrogen receptor-positive (ER+) breast cancer drive pan-endocrine therapy resistance and metastatic progression. Growth of breast tumors driven by ESR1 fusions at primary and metastatic sties can be suppressed with a CDK4/6 inhibitor