Psychological interventions in asthma

Asthma is a multifactorial chronic respiratory disease characterised by recurrent episodes of airway obstruction. The current management of asthma focuses principally on pharmacological treatments, which have a strong evidence base underlying their use. However, in clinical practice, poor symptom control remains a common problem for patients with asthma. Living with asthma has been linked with psychological co-morbidity including anxiety, depression, panic attacks and behavioural factors such as poor adherence and suboptimal self-management. Psychological disorders have a higher-than-expected prevalence in patients with difficult-to-control asthma. As psychological considerations play an important role in the management of people with asthma, it is not surprising that many psychological therapies have been applied in the management of asthma. There are case reports which support their use as an adjunct to pharmacological therapy in selected individuals, and in some clinical trials, benefit is demonstrated, but the evidence is not consistent. When findings are quantitatively synthesised in meta-analyses, no firm conclusions are able to be drawn and no guidelines recommend psychological interventions. These inconsistencies in findings may in part be due to poor study design, the combining of results of studies using different interventions and the diversity of ways patient benefit is assessed. Despite this weak evidence base, the rationale for psychological therapies is plausible, and this therapeutic modality is appealing to both patients and their clinicians as an adjunct to conventional pharmacological treatments. What are urgently required are rigorous evaluations of psychological therapies in asthma, on a par to the quality of pharmaceutical trials. From this evidence base, we can then determine which interventions are beneficial for our patients with asthma management and more specifically which psychological therapy is best suited for each patient

Orientational order on curved surfaces - the high temperature region

We study orientational order, subject to thermal fluctuations, on a fixed curved surface. We derive, in particular, the average density of zeros of Gaussian distributed vector fields on a closed Riemannian manifold. Results are compared with the density of disclination charges obtained from a Coulomb gas model. Our model describes the disordered state of two dimensional objects with orientational degrees of freedom, such as vector ordering in Langmuir monolayers and lipid bilayers above the hexatic to fluid transition.Comment: final version, 13 Pages, 2 figures, uses iopart.cl

Variational theory of flux-line liquids

We formulate a variational (Hartree like) description of flux line liquids which improves on the theory we developed in an earlier paper [A.M. Ettouhami, Phys. Rev. B 65, 134504 (2002)]. We derive, in particular, how the massive term confining the fluctuations of flux lines varies with temperature and show that this term vanishes at high enough temperatures where the vortices behave as freely fluctuating elastic lines.Comment: 10 pages, 1 postscript figur

Enhancement of pair correlation in a one-dimensional hybridization model

We propose an integrable model of one-dimensional (1D) interacting electrons coupled with the local orbitals arrayed periodically in the chain. Since the local orbitals are introduced in a way that double occupation is forbidden, the model keeps the main feature of the periodic Anderson model with an interacting host. For the attractive interaction, it is found that the local orbitals enhance the effective mass of the Cooper-pair-like singlets and also the pair correlation in the ground state. However, the persistent current is depressed in this case. For the repulsive interaction case, the Hamiltonian is non-Hermitian but allows Cooper pair solutions with small momenta, which are induced by the hybridization between the extended state and the local orbitals.Comment: 11 page revtex, no figur

Quantum critical phenomena of long-range interacting bosons in a time-dependent random potential

We study the superfluid-insulator transition of a particle-hole symmetric system of long-range interacting bosons in a time-dependent random potential in two dimensions, using the momentum-shell renormalization-group method. We find a new stable fixed point with non-zero values of the parameters representing the short- and long-range interactions and disorder when the interaction is asymptotically logarithmic. This is contrasted to the non-random case with a logarithmic interaction, where the transition is argued to be first-order, and to the $1/r$ Coulomb interaction case, where either a first-order transition or an XY-like transition is possible depending on the parameters. We propose that our model may be relevant in studying the vortex liquid-vortex glass transition of interacting vortex lines in point-disordered type-II superconductors.Comment: 10 pages, 3 figure

Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress

Acknowledgments We thank Alexander Johnson (yhb1D/D), Karl Kuchler (sodD/D mutants), Janet Quinn (hog1D/D, hog1/cap1D/D, trx1D/D) and Peter Staib (ssu1D/D) for providing mutant strains. We acknowledge helpful discussions with our colleagues from the Microbial Pathogenicity Mechanisms Department, Fungal Septomics and the Microbial Biochemistry and Physiology Research Group at the Hans Kno¨ll Institute (HKI), specially Ilse D. Jacobsen, Duncan Wilson, Sascha Brunke, Lydia Kasper, Franziska Gerwien, Sea´na Duggan, Katrin Haupt, Kerstin Hu¨nniger, and Matthias Brock, as well as from our partners in the FINSysB Network. Author Contributions Conceived and designed the experiments: PM HW IMB AJPB OK BH. Performed the experiments: PM CD HW. Analyzed the data: PM HW IMB AJPB OK BH. Wrote the paper: PM HW OK AJPB BH.Peer reviewedPublisher PD

Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership

This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands

Fertility, Living Arrangements, Care and Mobility

There are four main interconnecting themes around which the contributions in this book are based. This introductory chapter aims to establish the broad context for the chapters that follow by discussing each of the themes. It does so by setting these themes within the overarching demographic challenge of the twenty-first century – demographic ageing. Each chapter is introduced in the context of the specific theme to which it primarily relates and there is a summary of the data sets used by the contributors to illustrate the wide range of cross-sectional and longitudinal data analysed

Vortex wandering in a forest of splayed columnar defects

We investigate the scaling properties of single flux lines in a random pinning landscape consisting of splayed columnar defects. Such correlated defects can be injected into Type II superconductors by inducing nuclear fission or via direct heavy ion irradiation. The result is often very efficient pinning of the vortices which gives, e.g., a strongly enhanced critical current. The wandering exponent \zeta and the free energy exponent \omega of a single flux line in such a disordered environment are obtained analytically from scaling arguments combined with extreme-value statistics. In contrast to the case of point disorder, where these exponents are universal, we find a dependence of the exponents on details in the probability distribution of the low lying energies of the columnar defects. The analytical results show excellent agreement with numerical transfer matrix calculations in two and three dimensions.Comment: 11 pages, 9 figure