Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man

Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin. This study should show, whether vasoactive intestinal polypeptide (VIP), a partial agonist of secretin, may also be involved in the mediation of the hydrokinetic effect. Furthermore, plasma concentrations of somatostatin-like immunoreactivity (SLI) were measured in order to check whether this counterregulating hormone is also released by bile and TDC. Twenty investigations were carried out on 10 fasting healthy volunteers provided with a double-lumen Dreiling tube. Bile and TDC were intraduodenally applied in doses of 2-6 g and 200-600 mg, respectively, at 65-min intervals. Plasma samples were withdrawn at defined intervals for radioimmunological determination of VIP and SLI. Duodenal juice was collected in 10-min fractions and analyzed for volume, pH, bicarbonate, lipase, trypsin, and amylase. I.d. application of bile or TDC dose dependently stimulated hydrokinetic and ecbolic pancreatic secretion. Bile exerted a slightly stronger effect than TDC. Pancreatic response was simultaneously accompanied by a significant increase of plasma VIP and SLI concentrations. The effect of bile on integrated plasma VIP and SLI concentrations seems to be dose dependent; the effect of TDC on integrated SLI, too. For the increase of integrated plasma VIP concentrations after TDC no dose-response relation could be established. We conclude that VIP may be a further mediator of bile-induced volume and bicarbonate secretion. The release of plasma SLI indicates that inhibitory mechanisms concomitantly are triggered by i.d. bile and TDC, as already shown during digestion for the intestinal phase of pancreatic secretion

The Physical Properties of LBGs at z>5: Outflows and the "pre-enrichment problem"

We discuss the properties of Lyman Break galaxies (LBGs) at z>5 as determined from disparate fields covering approximately 500 sq. arcmin. While the broad characteristics of the LBG population has been discussed extensively in the literature, such as luminosity functions and clustering amplitude, we focus on the detailed physical properties of the sources in this large survey (>100 with spectroscopic redshifts). Specifically, we discuss ensemble mass estimates, stellar mass surface densities, core phase space densities, star-formation intensities, characteristics of their stellar populations, etc as obtained from multi-wavelength data (rest-frame UV through optical) for a subsample of these galaxies. In particular, we focus on evidence that these galaxies drive vigorous outflows and speculate that this population may solve the so-called ``pre-enrichment problem''. The general picture that emerges from these studies is that these galaxies, observed about 1 Gyr after the Big Bang, have properties consistent with being the progenitors of the densest stellar systems in the local Universe -- the centers of old bulges and early type galaxies.Comment: 4 pages, to appear in "Pathways Through an Eclectic Universe", J. H. Knappen, T. J. Mahoney, and A. Vazedekis (Eds.), ASP Conf. Ser., 200

The detection of FIR emission from high redshift star-forming galaxies in the ECDF-S

ABRIDGED: We have used the LABOCA Survey of the ECDF-S (LESS) to investigate rest-frame FIR emission from typical SF systems (LBGs) at redshift 3, 4, and 5. We initially concentrate on LBGs at z~3 and select three subsamples on stellar mass, extinction corrected SF and rest-frame UV-magnitude. We produce composite 870micron images of the typical source in our subsamples, obtaining ~4sigma detections and suggesting a correlation between FIR luminosity and stellar mass. We apply a similar procedure to our full samples at z~3, 4, 4.5 and 5 and do not obtain detections - consistent with a simple scaling between FIR luminosity and stellar mass. In order to constrain the FIR SED of these systems we explore their emission at multiple wavelengths spanning the peak of dust emission at z~3 using the Herschel SPIRE observations of the field. We obtain detections at multiple wavelengths for both our stellar mass and UV-magnitude selected samples, and find a best-fit SED with T_dust in the ~33-41K range. We calculate L_FIR, obscured SFRs and M_dust, and find that a significant fraction of SF in these systems is obscured. Interestingly, our extinction corrected SFR sample does not display the large FIR fluxes predicted from its red UV-spectral slope. This suggests that the method of assuming an intrinsic UV-slope and correcting for dust attenuation may be invalid for this sample - and that these are not in fact the most actively SF systems. All of our z~3 samples fall on the `main sequence' of SF galaxies at z~3 and our detected subsamples are likely to represent the high obscuration end of LBGs at their epoch. We compare the FIR properties of our subsamples with various other populations, finding that our stellar mass selected sample shows similar FIR characteristics to SMGs at the same epoch and therefore potentially represents the low L_FIR end of the high redshift FIR luminosity function.Comment: 18 pages, 10 figure, MNRAS accepted, corrected typos, acknowledgements adde