2,861 research outputs found
Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin. This study should show, whether vasoactive intestinal polypeptide (VIP), a partial agonist of secretin, may also be involved in the mediation of the hydrokinetic effect. Furthermore, plasma concentrations of somatostatin-like immunoreactivity (SLI) were measured in order to check whether this counterregulating hormone is also released by bile and TDC. Twenty investigations were carried out on 10 fasting healthy volunteers provided with a double-lumen Dreiling tube. Bile and TDC were intraduodenally applied in doses of 2-6 g and 200-600 mg, respectively, at 65-min intervals. Plasma samples were withdrawn at defined intervals for radioimmunological determination of VIP and SLI. Duodenal juice was collected in 10-min fractions and analyzed for volume, pH, bicarbonate, lipase, trypsin, and amylase. I.d. application of bile or TDC dose dependently stimulated hydrokinetic and ecbolic pancreatic secretion. Bile exerted a slightly stronger effect than TDC. Pancreatic response was simultaneously accompanied by a significant increase of plasma VIP and SLI concentrations. The effect of bile on integrated plasma VIP and SLI concentrations seems to be dose dependent; the effect of TDC on integrated SLI, too. For the increase of integrated plasma VIP concentrations after TDC no dose-response relation could be established. We conclude that VIP may be a further mediator of bile-induced volume and bicarbonate secretion. The release of plasma SLI indicates that inhibitory mechanisms concomitantly are triggered by i.d. bile and TDC, as already shown during digestion for the intestinal phase of pancreatic secretion
The Physical Properties of LBGs at z>5: Outflows and the "pre-enrichment problem"
We discuss the properties of Lyman Break galaxies (LBGs) at z>5 as determined
from disparate fields covering approximately 500 sq. arcmin. While the broad
characteristics of the LBG population has been discussed extensively in the
literature, such as luminosity functions and clustering amplitude, we focus on
the detailed physical properties of the sources in this large survey (>100 with
spectroscopic redshifts). Specifically, we discuss ensemble mass estimates,
stellar mass surface densities, core phase space densities, star-formation
intensities, characteristics of their stellar populations, etc as obtained from
multi-wavelength data (rest-frame UV through optical) for a subsample of these
galaxies. In particular, we focus on evidence that these galaxies drive
vigorous outflows and speculate that this population may solve the so-called
``pre-enrichment problem''. The general picture that emerges from these studies
is that these galaxies, observed about 1 Gyr after the Big Bang, have
properties consistent with being the progenitors of the densest stellar systems
in the local Universe -- the centers of old bulges and early type galaxies.Comment: 4 pages, to appear in "Pathways Through an Eclectic Universe", J. H.
Knappen, T. J. Mahoney, and A. Vazedekis (Eds.), ASP Conf. Ser., 200
The detection of FIR emission from high redshift star-forming galaxies in the ECDF-S
ABRIDGED: We have used the LABOCA Survey of the ECDF-S (LESS) to investigate
rest-frame FIR emission from typical SF systems (LBGs) at redshift 3, 4, and 5.
We initially concentrate on LBGs at z~3 and select three subsamples on stellar
mass, extinction corrected SF and rest-frame UV-magnitude. We produce composite
870micron images of the typical source in our subsamples, obtaining ~4sigma
detections and suggesting a correlation between FIR luminosity and stellar
mass. We apply a similar procedure to our full samples at z~3, 4, 4.5 and 5 and
do not obtain detections - consistent with a simple scaling between FIR
luminosity and stellar mass. In order to constrain the FIR SED of these systems
we explore their emission at multiple wavelengths spanning the peak of dust
emission at z~3 using the Herschel SPIRE observations of the field. We obtain
detections at multiple wavelengths for both our stellar mass and UV-magnitude
selected samples, and find a best-fit SED with T_dust in the ~33-41K range. We
calculate L_FIR, obscured SFRs and M_dust, and find that a significant fraction
of SF in these systems is obscured. Interestingly, our extinction corrected SFR
sample does not display the large FIR fluxes predicted from its red UV-spectral
slope. This suggests that the method of assuming an intrinsic UV-slope and
correcting for dust attenuation may be invalid for this sample - and that these
are not in fact the most actively SF systems. All of our z~3 samples fall on
the `main sequence' of SF galaxies at z~3 and our detected subsamples are
likely to represent the high obscuration end of LBGs at their epoch. We compare
the FIR properties of our subsamples with various other populations, finding
that our stellar mass selected sample shows similar FIR characteristics to SMGs
at the same epoch and therefore potentially represents the low L_FIR end of the
high redshift FIR luminosity function.Comment: 18 pages, 10 figure, MNRAS accepted, corrected typos,
acknowledgements adde
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