Key Messages der Konferenz zur 5. Multiprojektmanagement-Studie

StudieDie 5. Benchmarkingstudie in Multiprojektmanagement durch die Technische Universität Berlin und die ZHAW School of Management an Law wird demnächst abgeschlossen. Untersucht werden die Themen "Project Portfolio Dynamics", "Risk & Opportunity Management im Multiprojektumfeld" sowie "Kommunikation im Multiprojektumfeld"

Folding polyominoes into cubes

Which polyominoes can be folded into a cube, using only creases along edges of the square lattice underlying the polyomino, with fold angles of $\pm 90^\circ$ and $\pm 180^\circ$, and allowing faces of the cube to be covered multiple times? Prior results studied tree-shaped polyominoes and polyominoes with holes and gave partial classifications for these cases. We show that there is an algorithm deciding whether a given polyomino can be folded into a cube. This algorithm essentially amounts to trying all possible ways of mapping faces of the polyomino to faces of the cube, but (perhaps surprisingly) checking whether such a mapping corresponds to a valid folding is equivalent to the unlink recognition problem from topology. We also give further results on classes of polyominoes which can or cannot be folded into cubes. Our results include (1) a full characterisation of all tree-shaped polyominoes that can be folded into the cube (2) that any rectangular polyomino which contains only one simple hole (out of five different types) does not fold into a cube, (3) a complete characterisation when a rectangular polyomino with two or more unit square holes (but no other holes) can be folded into a cube, and (4) a sufficient condition when a simply-connected polyomino can be folded to a cube. These results answer several open problems of previous work and close the cases of tree-shaped polyominoes and rectangular polyominoes with just one simple hole

Matching factors for Delta S=1 four-quark operators in RI/SMOM schemes

The non-perturbative renormalization of four-quark operators plays a significant role in lattice studies of flavor physics. For this purpose, we define regularization-independent symmetric momentum-subtraction (RI/SMOM) schemes for Delta S=1 flavor-changing four-quark operators and provide one-loop matching factors to the MS-bar scheme in naive dimensional regularization. The mixing of two-quark operators is discussed in terms of two different classes of schemes. We provide a compact expression for the finite one-loop amplitudes which allows for a straightforward definition of further RI/SMOM schemes.Comment: 22 pages, 5 figure

Corticospinal excitability of primary motor cortex handfield in the older person and the patient suffer parcinson’s disease measered with transcranial magnetic stimulation

Mit der transkraniellen Doppelreiz- und Einzelreizstimulation wurde die Erregbarkeit des primärmotorischen Handareals bei 11 alten gesunden Probanden und 15 an Morbus Parkinson Erkrankten untersucht. Im Alter zeigte sich eine Anhebung der motorischen Ruheschwelle, eine Verkürzung der postexzitatorischen Innervationsstille und eine aufgehobene intrakortikale Doppelpulsinhibition im linken M1-Hand. Die Parkinsonpatienten zeigten eine fazilitierte Stimulus-Antwort-Kurve und eine reduzierte intrakortikale Doppelpulsfazilitation. Die Befunde spiegeln altersbedingte und krankheitsbedingte Veränderungen auf Neurotransmitterebene, bzw. Kompensationsmechanismen.Determination of intracortical excitabiliy of primary motor cortex handfield in 11 old healthy persons and 15 patients suffering parcinsons disease with transcranial double and single pulse stimulation showed increased resting motor treshold, shortened silent period and raised intracortical double pulse inhibition of left M1-hand with age. Patients suffering parcinsons disease were characterised by a facilitated stimulus-response-curve and a reduced intracortical double-pulse facilitation. These findings may reflect mechanisms of compensation and/or alterations in neurotransmitter function

Separation of Sister Chromatids in Mitosis Requires the Drosophila pimples Product, a Protein Degraded after the Metaphase/Anaphase Transition

AbstractMutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of sister chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still connected in the centromeric region are observed in the following mitosis. pimples encodes a novel protein that is rapidly degraded in mitosis. Our observations suggest that Pimples and Three rows act during mitosis to release the cohesion between sister centromeres

To Softmax, or not to Softmax: that is the question when applying Active Learning for Transformer Models

Despite achieving state-of-the-art results in nearly all Natural Language Processing applications, fine-tuning Transformer-based language models still requires a significant amount of labeled data to work. A well known technique to reduce the amount of human effort in acquiring a labeled dataset is \textit{Active Learning} (AL): an iterative process in which only the minimal amount of samples is labeled. AL strategies require access to a quantified confidence measure of the model predictions. A common choice is the softmax activation function for the final layer. As the softmax function provides misleading probabilities, this paper compares eight alternatives on seven datasets. Our almost paradoxical finding is that most of the methods are too good at identifying the true most uncertain samples (outliers), and that labeling therefore exclusively outliers results in worse performance. As a heuristic we propose to systematically ignore samples, which results in improvements of various methods compared to the softmax function