Relationships between Gene Expression and Brain Wiring in the Adult Rodent Brain

We studied the global relationship between gene expression and neuroanatomical connectivity in the adult rodent brain. We utilized a large data set of the rat brain “connectome” from the Brain Architecture Management System (942 brain regions and over 5000 connections) and used statistical approaches to relate the data to the gene expression signatures of 17,530 genes in 142 anatomical regions from the Allen Brain Atlas. Our analysis shows that adult gene expression signatures have a statistically significant relationship to connectivity. In particular, brain regions that have similar expression profiles tend to have similar connectivity profiles, and this effect is not entirely attributable to spatial correlations. In addition, brain regions which are connected have more similar expression patterns. Using a simple optimization approach, we identified a set of genes most correlated with neuroanatomical connectivity, and find that this set is enriched for genes involved in neuronal development and axon guidance. A number of the genes have been implicated in neurodevelopmental disorders such as autistic spectrum disorder. Our results have the potential to shed light on the role of gene expression patterns in influencing neuronal activity and connectivity, with potential applications to our understanding of brain disorders. Supplementary data are available at http://www.chibi.ubc.ca/ABAMS

Cas clinique: Convulsions après administration d'indométacine

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Evolution du traitement chirurgical du cancer du rectum primitif et métastatique.

There are many ways by which the surgeon can optimize curative resection for rectal cancer. Appropriate margins with total mesorectal excision, should be the goals for tumors in the lower two-thirds of the rectum. Reconstruction should be performed, whenever technically possible, by a colonic J-pouch. Preservation of pelvic autonomic nerves is possible in most cases, reducing the risk of postoperative sexual and urinary dysfunction. New techniques increase the frequency of curative treatments of metastatic disease. Towards either the primary or the metastatic disease, the new therapeutic strategies offer an hope of cure, and a better quality of life, to an increasing number of patients.English AbstractJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Traitement a visée curative des carcinoses péritonéales d'origine colorectale et appendiculaire par chirurgie maximaliste et chimiothérapie hyperthermique intrapéritonéale peropératoire.

Peritoneal carcinomatosis (PC) from colorectal cancer is a dreadful situation characterized by a rapid and mortal evolution (median survival of 5 to 7 months amongst the series published in the literature). The classical treatment includes systemic chemotherapy whether or not associated with palliative surgery. Since the early nineties, locoregional treatments combining extensive cytoreductive surgery with intraperitoneal hyperthermic chemotherapy have been developed, affording some patients a cure and yealding a 5-year survival as high as 30 to 40% in some series. However, it is associated with high morbidity and mortality rates.English AbstractJournal ArticleReviewSCOPUS: re.jinfo:eu-repo/semantics/publishe

Double batch cider distillation: Influence of the recycling of the separated fractions

National audienceThis study aimed to analyse the behaviour of volatile compounds during double batch cider distillation to produce Calvados. More precisely, it allowed to analyse the influence of the recycling of the separated fractions to manage the cuts according to the quality target. 700 L of cider were distilled with a 115 L Charentais still and 28 congeners were quantified into 65 samples from nine cider and two brouillis distillations. Most of alcohols were totally recovered into the heart of the second brouillis distillation, except 2-phenylethanol recovered at 5.4% because of its low volatility. For the same reason, esters as 2-phenylacetate, ethyl 2hydroxypropanoate and diethyl butanedioate were significantly lost in the residues. Stopping distillations beyond 2 %v/v would increase their recovery but at an increasing cost. Other compounds are strongly concentrated in the head fractions. Among them, some such as ethyl acetate and acetaldehyde have negative impact on quality, while others such as ethyl decanoate and ethyl hexanoate bring floral notes. As these positive compounds are less concentrated in the head fraction of brouillis distillation than cider distillation, it is best, if negative compounds must be eliminated, to choose to extract head from brouillis distillation. Other possibility is to limit production of negative compounds

Survival and quality of life after palliative surgery for neoplastic gastrointestinal obstruction.

The aim was to identify the prognostic factors which relate to the results, in terms of survival and quality of life, of palliative surgery in cancer patients presenting with an occlusion.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Occlusions intestinales chez le patient cancéreux: résultats de la chirurgie palliative.

The study aim was to investigate predictive factors related to the results, in terms of survival and quality of life, of palliative surgery in cancer patients presenting with intestinal obstruction.English AbstractJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Traitement chirurgical des métastases digestives de mélanome.

Metastases of melanoma are frequent. On the gastro-intestinal tract, commonest localizations are small bowel, stomach and colon. Surgical treatment of digestive metastases from melanoma is not well known and its value is still debated.English AbstractJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Carcinome epidermoide colorectal et hypercalcemie paraneoplasique

SCOPUS: ar.jinfo:eu-repo/semantics/publishe