Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection

The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways\ud of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during\ud deep brain stimulation surgery as participants engage in a decision task to examine the role of the human STN in action selection. We\ud demonstrate that spiking activity in the STN increases when participants engage in a decision and that the level of spiking activity\ud increases with the degree of decision conflict. These data implicate the STN as an important mediator of action selection during decision\ud processes.\u

Remarks on the Configuration Space Approach to Spin-Statistics

The angular momentum operators for a system of two spin-zero indistinguishable particles are constructed, using Isham's Canonical Group Quantization method. This mathematically rigorous method provides a hint at the correct definition of (total) angular momentum operators, for arbitrary spin, in a system of indistinguishable particles. The connection with other configuration space approaches to spin-statistics is discussed, as well as the relevance of the obtained results in view of a possible alternative proof of the spin-statistics theorem.Comment: 18 page

Chirikov Diffusion in the Asteroidal Three-Body Resonance (5,-2,-2)

The theory of diffusion in many-dimensional Hamiltonian system is applied to asteroidal dynamics. The general formulations developed by Chirikov is applied to the Nesvorn\'{y}-Morbidelli analytic model of three-body (three-orbit) mean-motion resonances (Jupiter-Saturn-asteroid system). In particular, we investigate the diffusion \emph{along} and \emph{across} the separatrices of the (5,-2,-2) resonance of the (490) Veritas asteroidal family and their relationship to diffusion in semi-major axis and eccentricity. The estimations of diffusion were obtained using the Melnikov integral, a Hadjidemetriou-type sympletic map and numerical integrations for times up to $10^{8}$ years.Comment: 27 pages, 6 figure

Disordered Regimes of the one-dimensional complex Ginzburg-Landau equation

I review recent work on the ``phase diagram'' of the one-dimensional complex Ginzburg-Landau equation for system sizes at which chaos is extensive. Particular attention is paid to a detailed description of the spatiotemporally disordered regimes encountered. The nature of the transition lines separating these phases is discussed, and preliminary results are presented which aim at evaluating the phase diagram in the infinite-size, infinite-time, thermodynamic limit.Comment: 14 pages, LaTeX, 9 figures available by anonymous ftp to amoco.saclay.cea.fr in directory pub/chate, or by requesting them to [email protected]

On the geometry of quantum indistinguishability

An algebraic approach to the study of quantum mechanics on configuration spaces with a finite fundamental group is presented. It uses, in an essential way, the Gelfand-Naimark and Serre-Swan equivalences and thus allows one to represent geometric properties of such systems in algebraic terms. As an application, the problem of quantum indistinguishability is reformulated in the light of the proposed approach. Previous attempts aiming at a proof of the spin-statistics theorem in non-relativistic quantum mechanics are explicitly recast in the global language inherent to the presented techniques. This leads to a critical discussion of single-valuedness of wave functions for systems of indistinguishable particles. Potential applications of the methods presented in this paper to problems related to quantization, geometric phases and phase transitions in spin systems are proposed.Comment: 24 page

Diagnostic accuracy of the primary care screener for affective disorder (PC-SAD) in primary care

Background: Depression goes often unrecognised and untreated in non-psychiatric medical settings. Screening has recently gained acceptance as a first step towards improving depression recognition and management. The Primary Care Screener for Affective Disorders (PC-SAD) is a self-administered questionnaire to screen for Major Depressive Disorder (MDD) and Dysthymic Disorder (Dys) which has a sophisticated scoring algorithm that confers several advantages. This study tested its performance against a ‘gold standard’ diagnostic interview in primary care. Methods: A total of 416 adults attending 13 urban general internal medicine primary care practices completed the PC-SAD. Of 409 who returned a valid PC-SAD, all those scoring positive (N=151) and a random sample (N=106) of those scoring negative were selected for a 3-month telephone follow-up assessment including the administration of the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I) by a psychiatrist who was masked to PC-SAD results. Results: Most selected patients (N=212) took part in the follow-up assessment. After adjustment for partial verification bias the sensitivity, specificity, positive and negative predictive value for MDD were 90%, 83%, 51%, and 98%. For Dys, the corresponding figures were 78%, 79%, 8%, and 88%. Conclusions: While some study limitations suggest caution in interpreting our results, this study corroborated the diagnostic validity of the PC-SAD, although the low PPV may limit its usefulness with regard to Dys. Given its good psychometric properties and the short average administration time, the PC-SAD might be the screening instrument of choice in settings where the technology for computer automated scoring is available

Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants

New oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral anticoagulants DOACs (dabigtran, rivaroxban, apixban, and edoxban) in the treatment of adults with atri-al fibrillation. Electronic databases including Medline, Embase, International Pharmaceutical Abstract (IPA), Scopus, CINAHL, the Web of Science and Cochrane were searched from 2008 through 2016 for original articles. Studies pub-lished in English reporting MRPs of DOACs in adult patients with AF were in-cluded. Seventeen studies were identified using standardized protocols, and two reviewers serially abstracted data from each article. Most articles were inconclusive on major safety end points including major bleeding. Data on major safety end points were combined with efficacy. Most studies inconsistently reported adverse drug reactions and not adverse events or medication error, and no definitions were consistent across studies. Some harmful drug effects were not assessed in studies and may have been overlooked. Little evidence is provided on MRPs of DOACs in patients with AF and, therefore, further studies are needed to establish the safety of DOACs in real-life clinical practice

The dispersion-managed Ginzburg-Landau equation and its application to femtosecond lasers

The complex Ginzburg-Landau equation has been used extensively to describe various non-equilibrium phenomena. In the context of lasers, it models the dynamics of a pulse by averaging over the effects that take place inside the cavity. Ti:sapphire femtosecond lasers, however, produce pulses that undergo significant changes in different parts of the cavity during each round-trip. The dynamics of such pulses is therefore not adequately described by an average model that does not take such changes into account. The purpose of this work is severalfold. First we introduce the dispersion-managed Ginzburg-Landau equation (DMGLE) as an average model that describes the long-term dynamics of systems characterized by rapid variations of dispersion, nonlinearity and gain in a general setting, and we study the properties of the equation. We then explain how in particular the DMGLE arises for Ti:sapphire femtosecond lasers and we characterize its solutions. In particular, we show that, for moderate values of the gain/loss parameters, the solutions of the DMGLE are well approximated by those of the dispersion-managed nonlinear Schrodinger equation (DMNLSE), and the main effect of gain and loss dynamics is simply to select one among the one-parameter family of solutions of the DMNLSE.Comment: 22 pages, 4 figures, to appear in Nonlinearit

Measurements of low-energy, re-entrant albedo protons by the HEPD-01 space-borne detector

Cosmic rays' interactions with the residual atmosphere surrounding the Earth produce a variety of particles, like electrons, positrons, protons, anti -protons, and Helium nuclei that can be observed below the local geomagnetic cutoff. In this work, we present new measurements of downward -going, albedo proton fluxes with kinetic energy in the range similar to 40- similar to 250 MeV, performed by the High -Energy Particle Detector (HEPD-01) on board of the China Seismo-Electromagnetic Satellite - CSES-01 - at an altitude of similar to 500 km. Employing a dedicated trajectory -tracing simulation routine, the protons collected by HEPD-01 are classified into quasi -trapped (QT), long lifetime ( & Agrave;10 s) particles concentrating in the equatorial region of the Earth, and un-trapped (UT), distributed at all latitudes; the latter includes both precipitating short lifetime particles (UT S ) and pseudotrapped long lifetime (UT L ) populations, abundant in the so-called penumbra regions. The temporal trend of re-entrant protons between 2018 and 2022 is also reported, assessing the stability of such population during the data -taking period of HEPD-01; this highlights their independence from the long-term modulating effect of the solar activity

Multispacecraft Observations of Protons and Helium Nuclei in Some Solar Energetic Particle Events toward the Maximum of Cycle 25

The intricate behavior of particle acceleration and transport mechanisms complicates the overall efforts in formulating a comprehensive understanding of solar energetic particle (SEP) events; these efforts include observations of low-energy particles (from tens of keV to hundreds of MeV) by space-borne instruments and measurements by the ground-based neutron monitors of the secondary particles generated in the Earth atmosphere by SEPs in the GeV range. Numerous space-borne missions provided good data on the nature/characteristics of these solar particles in past solar cycles, but more recently-concurrently with the rise toward the maximum of solar cycle 25-the High-Energy Particle Detector (HEPD-01) proved to be well suited for the study of solar physics and space weather. Its nominal 30-300 MeV energy range for protons can enlarge the detection capabilities of solar particles at low Earth orbit, closer to the injection limit of many SEP events. In this work, we characterize three SEP events within the first six months of 2022 through spectral and velocity dispersion analysis, assessing the response of HEPD-01 to >M1 events