190 research outputs found
Existence results for non-smooth second order differential inclusions, Convergence result for a numerical scheme and applications for modelling inelastic collisions
We are interested in existence results for second order differential
inclusions, involving finite number of unilateral constraints in an abstract
framework. These constraints are described by a set-valued operator, more
precisely a proximal normal cone to a time-dependent set. Moreover we extend a
numerical scheme, introduced in [8] and proved a convergence result. We propose
applications in modelling inelastic collisions between rigid particles too.Comment: 22 pages, 1 figur
Micro-Macro Modelling of an Array of Spheres Interacting Through Lubrication Forces
We consider here a discrete system of spheres interacting through a
lubrication force. This force is dissipative, and singular near contact: it
behaves like the reciprocal of interparticle distance. We propose a macroscopic
constitutive equation which is built as the natural continuous counterpart of
this microscopic lubrication model. This model, which is of the newtonian type,
relies on an elongational viscosity, which is proportional to the reciprocal of
the local fluid fraction. We then establish the convergence in a weak sense of
solutions to the discrete problem towards the solution to the partial
differential equation which we identified as the macroscopic constitutive
equation
Numerical Simulation of Gluey Particles
We propose here a model and a numerical scheme to compute the motion of rigid
particles interacting through the lubrication force. In the case of a particle
approaching a plane, we propose an algorithm and prove its convergence towards
the solutions to the gluey particle model proposed by B. Maury. We propose a
multi-particle version of this gluey model which is based on the projection of
the velocities onto a set of admissible velocities. Then, we describe a
multi-particle algorithm for the simulation of such systems and present
numerical results
Numerical simulation of rigid particles in Stokes flow: lubrication correction for any (regular) shape of particles
We address the problem of numerical simulation of suspensions of rigid particles in a Stokes flow. We focus on the inclusion of the singular short range interaction effects (lubrication effects) in the simulations when the particles come close one to another. The problem is solved without introducing new hypothesis nor model. As in [Lefebvre-Lepot, Merlet, Nguyen, JFM, 2015], the key idea is to decompose the velocity and pressure flows in a sum of a singular and a regular part. In this article, the singular part is computed using an explicit asymptotic expansion of the solution when the distance goes to zero. This expansion is similar to the asymptotic expansion proposed in [Hillairet, Kelai, Asymptotic Analysis, 2015] but is more appropriate for numerical simulations of suspensions. It can be computed for any shape of particles. Using [Hillairet, Kelai, Asymptotic Analysis, 2015] as an intermediate result, we prove that the remaining part is regular in the sense that it is bounded independently of the distance. As a consequence, only a small number of degrees of freedom are necessary to obtain accurate results. The method is tested in dimension 2 for clusters of two or three aligned particles with general rigid velocities. We show that, as expected, the convergence is independent on the distance
Problèmes de contact pour des particules en écoulement cisaillé
National audienceSee http://hal.archives-ouvertes.fr/docs/00/59/28/28/ANNEX/r_X8K316T9.pd
The Sparse Cardinal Sine Decomposition applied to Stokes integral equations
International audienceNumerical simulations of two-phase flows driven by viscosity (e.g. for bubble motions in glass melting process) rely on the ability to efficiently compute the solutions to discretized Stokes equations. When using boundary element methods to track fluid interfaces, one usually faces the problem of solving linear systems with a dense matrix with a size proportional to the system number of degrees of freedom. Acceleration techniques, based on the compression of the underlying matrix and efficient matrix vector products are known (Fast Multipole Method, H-matrices, etc.) but are usually rather cumbersome to develop. More recently, a new method was proposed, called the " Sparse Cardinal Sine Decomposition " , in the context of acoustic problems to tackle this kind of problem in some generality (in particular with respect to the Green kernel of the problem). The proposed contribution aims at showing the potential applicability of the method in the context of viscous flows governed by Stokes equations
Ecoulement dense autour d'une sphère traversant un nuage de grains
Une simulation bidimensionnelle d'une sphère se déplaçant à vitesse constante à l'intérieur d'un nuage de petits grains est présentée avec une méthode de type ?'Non-Smooth Contact Dynamic'' (sans effet de la gravité). Une zone granulaire dense, appelée ?'cluster'', à fraction volumique constante se construit progressivement autour de la sphère jusqu'à ce qu'un régime stationnaire apparaisse caractérisée par une taille constante du cluster en amont de la sphère qui augmente avec la fraction volumique initiale \phi_0 du nuage. Une analyse détaillée du champ de taux de déformation et du champ de contrainte à l'intérieur du cluster révèle que, malgré les variations spatiales de ces champs, le coefficient local de friction \mu et la fraction volumique \phi dépendent uniquement du nombre d'inertie I, ce qui signifie que la rhéologie du milieu granulaire est bien locale dans cet écoulement non parallèle. Les variations spatiales de I à l'intérieur même du cluster ne dépendent pas de la vitesse de déplacement de la sphère et explore une faible gamme allant de 0.01 à 0.1. L'influence des parois latérales sur l'écoulement et les forces est ensuite étudiée
Time of Lactation and Maternal Fucosyltransferase Genetic Polymorphisms Determine the Variability in Human Milk Oligosaccharides
Rationale: Human milk oligosaccharides (HMOs) vary among mothers and genetic
factors contribute to this variability.We assessed changes in HMO concentrations during
the first year of lactation and the relationship with FUT2 Secretor group and FUT3 Lewis
group defining genetic polymorphisms.
Methods: Milk samples were collected from lactating mothers participating in the LIFE
Child cohort in Leipzig, Germany. The concentrations of 24 HMOs in milk samples
collected at 3 months (N = 156), 6 months (N = 122), and 12 months (N = 28) were
measured using liquid chromatography. Concentrations of HMOs were compared at all
time-points and were tested for their associations with FUT2 and FUT3 genetic variations
by sPLS regression.
Results: FUT2 SNP rs601338 was found to predominantly define the Secretor status
Se-: 11.8% and it was highly correlated with 2′-fucosyllactose (2′FL, p < 0.001)
and lacto-N-fucosylpentaose-I (LNFP-I, p < 0.001). FUT3 SNPs rs28362459 and
rs812936 were found to define Lewis status (Le-: 5.9%) and correlated with
lacto-N-fucosylpentaose-II (LNFP-II, p < 0.001). A polygenic score predicted the
abundance of 2′FL levels within Secretors’ milk (adj. R2 = 0.58, p < 0.001). Mean
concentrations of most of the individual HMOs, as well as the sums of the measured
HMOs, the fucosylated HMOs, and the neutral HMOs were lower at 6 and 12 months
compared to 3 months (p < 0.001).
Conclusions: Secretor and Lewis status defined by specific FUT2 and FUT3 SNPs are
confirmed to be good proxies for specific individual HMOs and milk group variabilities.
The polygenic score developed here is an opportunity for clinicians to predict 2′FL
levels in milk of future mothers. These results show opportunities to strengthen our
understanding of factors controlling FUT2 and FUT3 functionality, the temporal changes
and variability of HMO composition during lactation and eventually their significance for
infant development
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