The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia

Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect of cannabis dose and cessation of use

p-Adic Models of Ultrametric Diffusion Constrained by Hierarchical Energy Landscapes

We demonstrate that p-adic analysis is a natural basis for the construction of a wide variety of the ultrametric diffusion models constrained by hierarchical energy landscapes. A general analytical description in terms of p-adic analysis is given for a class of models. Two exactly solvable examples, i.e. the ultrametric diffusion constraned by the linear energy landscape and the ultrametric diffusion with reaction sink, are considered. We show that such models can be applied to both the relaxation in complex systems and the rate processes coupled to rearrangenment of the complex surrounding.Comment: 14 pages, 6 eps figures, LaTeX 2.0

Nitrogen deposition does not enhance Sphagnum decomposition

Long-term additions of nitrogen (N) to peatlands have altered bryophyte growth, species dominance, N content in peat and peat water, and often resulted in enhanced Sphagnum decomposition rate. However, these results have mainly been derived from experiments in which N was applied as ammonium nitrate (NH4NO3), neglecting the fact that in polluted areas, wet deposition may be dominated either by NO3- or NH4+. We studied effects of elevated wet deposition of NO3- vs. NH4+ alone (8 or 56 kg N ha(-1) yr(-1) over and above the background of 8 kg N ha(-1) yr(-1) for 5 to 11 years) or combined with phosphorus (P) and potassium (K) on Sphagnum quality for decomposers, mass loss, and associated changes in hummock pore water in an ombrotrophic bog (Whim). Adding N, especially as NH4+, increased N concentration in Sphagnum, but did not enhance mass loss from Sphagnum. Mass loss seemed to depend mainly on moss species and climatic factors. Only high applications of N affected hummock pore water chemistry, which varied considerably over time. Overall, C and N cycling in this N treated bog appeared to be decoupled. We conclude that moss species, seasonal and annual variation in climatic factors, direct negative effects of N (NH4+ toxicity) on Sphagnum production, and indirect effects (increase in pH and changes in plant species dominance under elevated NO3- alone and with PK) drive Sphagnum decomposition and hummock C and N dynamics at Whim. (C) 2016 Elsevier B.V. All rights reserved.Peer reviewe

p-Adic description of characteristic relaxation in complex systems

This work is a further development of an approach to the description of relaxation processes in complex systems on the basis of the p-adic analysis. We show that three types of relaxation fitted into the Kohlrausch-Williams-Watts law, the power decay law, or the logarithmic decay law, are similar random processes. Inherently, these processes are ultrametric and are described by the p-adic master equation. The physical meaning of this equation is explained in terms of a random walk constrained by a hierarchical energy landscape. We also discuss relations between the relaxation kinetics and the energy landscapes.Comment: AMS-LaTeX (+iopart style), 9 pages, submitted to J.Phys.

The impact of mortality development on the number of centenarians in England and wales

The world is ageing both at an individual and a population level, and population ageing is truly a global phenomenon. Life expectancies at birth have increased at the global level from 47 years in the mid-20th century to around 70 years today, and are expected to rise to 76 years by the mid-21st century. The proportion of the world’s population aged 60 years and over has increased from 8% in the mid-20th century to 12%, and by 2050 it is expected to reach 21%. The emergence of large numbers of centenarians has accompanied this development. This paper outlines this emergence historically and the likely growth in the number of centenarians in the 21st century, in particular in England and Wales, analysing mortality trends since 1840 and the rise in the number of centenarians in the 20th and 21st centuries. The number of centenarians in England and Wales increased from around 160 in 1922 to almost 12,500 by 2012, but if mortality at all ages had remained constant from 1912 to 2012, then by 2012 the number of centenarians would only have been around 720. By 2100, the number of centenarians is expected to reach around 1.4 million, but if future mortality at all ages were to remain constant, then by 2100 the number of centenarians would be around 78,000. However, if predicted mortality for those aged 55 years and over was to decrease by an additional 5% every 5 years until 2100, then the number of centenarians in England and Wales would reach around 1.8 million by the end of the century

Classification of chili plant origin by using multilayer perceptron neural network

The geographical origin of the plants can affect the growth and hence the quality of the plants. In this research, the origin of the chili plants has been investigated by using Fourier transform infrared (FTIR) spectroscopy. The spectroscopy generated 3734 data with a wavenumber range from 4000–400 cm −1 . The pre-processing of the spectra was done by using baseline correction and vector normalization. The analysis was then taken in the biofingerprint area of 1800–900 cm −1 range which has 934 data points. Feature extraction for dimension reduction was achieved using principal component analysis (PCA). The PC scores from PCA were then fed into a k-means and a multilayer perceptron neural network (MLPNN). The k-means clustering shows that the samples can be distinguished into three different groups. Meanwhile, for the MLPNN, the number of the hidden layer's neurons and the learning rate of the system were optimized to get the best classification result. A hidden layer with twenty neurons had the highest accuracy, while a learning rate of 0.001 had the highest value of 100%

Dissociation of long-term verbal memory and fronto-executive impairment in first-episode psychosis

Background: Verbal memory is frequently and severely affected in schizophrenia and has been implicated as a mediator of poor clinical outcome. Whereas encoding deficits are well demonstrated, it is unclear whether retention is impaired. This distinction is important because accelerated forgetting implies impaired consolidation attributable to medial temporal lobe (MTL) dysfunction whereas impaired encoding and retrieval implicates involvement of prefrontal cortex. Method: We assessed a group of healthy volunteers (n=97) and pre-morbid IQ- and sex-matched first-episode psychosis patients (n=97), the majority of whom developed schizophrenia. We compared performance of verbal learning and recall with measures of visuospatial working memory, planning and attentional set-shifting, and also current IQ. Results: All measures of performance, including verbal memory retention, a memory savings score that accounted for learning impairments, were significantly impaired in the schizophrenia group. The difference between groups for delayed recall remained even after the influence of learning and recall was accounted for. Factor analyses showed that, in patients, all variables except verbal memory retention loaded on a single factor, whereas in controls verbal memory and fronto-executive measures were separable. Conclusions: The results suggest that IQ, executive function and verbal learning deficits in schizophrenia may reflect a common abnormality of information processing in prefrontal cortex rather than specific impairments in different cognitive domains. Verbal memory retention impairments, however, may have a different aetiology

Science and Ideology in Economic, Political, and Social Thought

This paper has two sources: One is my own research in three broad areas: business cycles, economic measurement and social choice. In all of these fields I attempted to apply the basic precepts of the scientific method as it is understood in the natural sciences. I found that my effort at using natural science methods in economics was met with little understanding and often considerable hostility. I found economics to be driven less by common sense and empirical evidence, then by various ideologies that exhibited either a political or a methodological bias, or both. This brings me to the second source: Several books have appeared recently that describe in historical terms the ideological forces that have shaped either the direct areas in which I worked, or a broader background. These books taught me that the ideological forces in the social sciences are even stronger than I imagined on the basis of my own experiences. The scientific method is the antipode to ideology. I feel that the scientific work that I have done on specific, long standing and fundamental problems in economics and political science have given me additional insights into the destructive role of ideology beyond the history of thought orientation of the works I will be discussing