1,413 research outputs found

    Gertrude to Hamlet

    Get PDF

    Calm down

    Get PDF
    Pages 134-13

    Analysis Of Tchaikowsky\u27s Overture Fantasy To Romeo And Juliet

    Get PDF
    Statement of the Problem This study is concerned with giving a detailed formal analysis of Tchaikowsky1s Overture Fantasy to Romeo and Juliet. Purpose The purpose of the analysis is to give the listener the overall design or pattern of the composition for an improvement in interpreting the work. It is to serve as a sort of guide by which the listener is enabled to see the structure and form of the composition. Its aim is to enable the listener to recognize the way in which the composer constructed this work; to recognize the various parts of the composition and how each part is related to every other part and to the whole. When one is able to interpret good music, then his appreciation, interest, and enjoyment are increased. The objective is to show how program music is constructed; and how various thematic schemes are used to tell a story. Delimitations This study does not include all of Tchaikowsky\u27s works. It is limited to the Overture Fantasy to Romeo and Juliet. It includes a biographical sketch of the composer; the influence of his country on his work; the influence of the Romantic Period on him; a resume of his style of writing, and how he wrote this particular composition. It gives the synopsis of the story which the composition itself tells and its complete analysis as to form

    Integrating spatial, temporal, referral problem and demographic approaches to establish systematic baseline data to inform future evaluations at the Pietermaritzburg Child and Family Centre.

    Get PDF
    Thesis (M.Soc.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2013.This exploratory retrospective record review extending from 1975 – 2013 of the Pietermaritzburg Child and Family Centre (hereafter referred to as the “CFC”) aimed to create a database to electronically capture CFC records to generate descriptive statistics, and the create CFC user profiles utilising multiple data analysis methodologies in order to create baseline data to inform future program evaluations. To date, no formal program evaluation has been conducted by the CFC, resulting in programs being launched without the backing of systematic and empirical data used to inform decisions. Data driven decision making is imperative when deciding on resource allocation to ensure maximum derived benefits. The study sample totalled 1974 records from the past three decades since CFC inception in 1975. These records were captured electronically in a Microsoft Access database. SPSS and ArcGIS were used to analyse the data to create service user profiles, and gather baseline data to inform future Needs Assessments and Program Evaluations. The study found temporal changes in CFC user demographics, referral problems, socio-economic standing, and referral schools since inception in 1975. The study explored, using geographic information software, client distribution of demographics, residence, referral problem, and CFC service reach, and found that there are significant geographical variations in each of these constructs. The geographic variations, together with the statistical findings highlight the importance of establishing Monitoring and Evaluation systems in order to stay relevant to the needs of CFC users. Further, findings suggest a tailored approach to CFC program development and focus, depending on future CFC priorities

    Large emergency-response exercises: qualitative characteristics - a survey

    Get PDF
    Exercises, drills, or simulations are widely used, by governments, agencies and commercial organizations, to simulate serious incidents and train staff how to respond to them. International cooperation has led to increasingly large-scale exercises, often involving hundreds or even thousands of participants in many locations. The difference between ‘large’ and ‘small’ exercises is more than one of size: (a) Large exercises are more ‘experiential’ and more likely to undermine any model of reality that single organizations may create; (b) they create a ‘play space’ in which organizations and individuals act out their own needs and identifications, and a ritual with strong social implications; (c) group-analytic psychotherapy suggests that the emotions aroused in a large group may be stronger and more difficult to control. Feelings are an unacknowledged major factor in the success or failure of exercises; (d) successful large exercises help improve the nature of trust between individuals and the organizations they represent, changing it from a situational trust to a personal trust; (e) it is more difficult to learn from large exercises or to apply the lessons identified; (f) however, large exercises can help develop organizations and individuals. Exercises (and simulation in general) need to be approached from a broader multidisciplinary direction if their full potential is to be realized

    Use of modified U1 snRNAs to inhibit HIV-1 replication

    Get PDF
    Control of RNA processing plays a central role in regulating the replication of HIV-1, in particular the 3′ polyadenylation of viral RNA. Based on the demonstration that polyadenylation of mRNAs can be disrupted by the targeted binding of modified U1 snRNA, we examined whether binding of U1 snRNAs to conserved 10 nt regions within the terminal exon of HIV-1 was able to inhibit viral structural protein expression. In this report, we demonstrate that U1 snRNAs complementary to 5 of the 15 regions targeted result in significant suppression of HIV-1 protein expression and viral replication coincident with loss of viral RNA. Suppression of viral gene expression is dependent upon appropriate assembly of a U1 snRNP particle as mutations of U1 snRNA that affect binding of U1 70K or Sm proteins significantly reduced efficacy. However, constructs lacking U1A binding sites retained significant anti-viral activity. This finding suggests a role for these mutants in situations where the wild-type constructs cause toxic effects. The conserved nature of the sequences targeted and the high efficacy of the constructs suggests that this strategy has significant potential as an HIV therapeutic

    Comparing flow cytometry with culture-based methods for microbial monitoring and as a diagnostic tool for assessing drinking water treatment processes

    Get PDF
    Flow cytometry (FCM) and the ability to measure both total and intact cell populations through DNA staining methodologies has rapidly gained attention and consideration across the water sector in the past decade. In this study, water quality monitoring was undertaken over three years across 213 drinking water treatment works (WTW) in the Scottish Water region (Total n = 39,340). Samples subject to routine regulatory microbial analysis using culture-based methods were also analysed using FCM. In addition to final treated water, the bacterial content in raw water was measured over a one-year period. Three WTW were studied in further detail using on-site inter-stage sampling and analysis with FCM. It was demonstrated that there was no clear link between FCM data and the coliform samples taken for regulatory monitoring. The disinfectant Ct value (Ct = mg·min/L) was the driving factor in determining final water cell viability and the proportion of intact cells (intact/total cells) and the frequency of coliform detections in the water leaving the WTW. However, the free chlorine residual, without consideration of treatment time, was shown to have little impact on coliform detections or cell counts. Amongst the three treatment trains monitored in detail, the membrane filtration WTW showed the greatest log removal and robustness in terms of final water intact cell counts. Flow cytometry was shown to provide insights into the bacteriological quality of water that adds significant value over and above that provided by traditional bacterial monitoring

    Which circulating antioxidant vitamins are confounded by socioeconomic deprivation? The MIDSPAN family study

    Get PDF
    <p><b>Background:</b> Antioxidant vitamins are often described as having “independent” associations with risk of cancer, cardiovascular disease (CVD) and mortality. We aimed to compare to what extent a range of antioxidant vitamins and carotenoids are associated with adulthood and childhood markers of socioeconomic deprivation and to adverse lifestyle factors.</p> <p><b>Methods and Findings:</b> Socioeconomic and lifestyle measures were available in 1040 men and 1298 women from the MIDSPAN Family Study (30–59 years at baseline) together with circulating levels of vitamins A, C, E, and carotenoids (α-carotene, β-carotene, lutein and lycopene). Markers of socioeconomic deprivation in adulthood were consistently as strongly associated with lower vitamin C and carotenoid levels as markers of adverse lifestyle; the inverse association with overcrowding was particularly consistent (vitamin C and carotenoids range from 19.1% [95% CI 30.3–6.0] to 38.8% [49.9–25.3] lower among those in overcrowded residencies). These associations were consistent after adjusting for month, classical CVD risk factors, body mass index, physical activity, vitamin supplements, dietary fat and fibre intake. Similar, but weaker, associations were seen for childhood markers of deprivation. The association of vitamin A or E were strikingly different; several adult adverse lifestyle factors associated with higher levels of vitamin A and E, including high alcohol intake for vitamin A (9.5% [5.7–13.5]) and waist hip ratio for vitamin E (9.5% [4.8–14.4]), with the latter associations partially explained by classical risk factors, particularly cholesterol levels.</p> <p><b>Conclusions:</b> Plasma vitamin C and carotenoids have strong inverse associations with adulthood markers of social deprivation, whereas vitamin A and E appear positively related to specific adverse lifestyle factors. These findings should help researchers better contextualize blood antioxidant vitamin levels by illustrating the potential limitations associated with making causal inferences without consideration of social deprivation.</p&gt

    Epidural anesthesia for the patient with type IV spinal muscular atrophy -A case report-

    Get PDF
    Spinal muscular atrophy (SMA) is a rare lower motor neurone disease in which anesthetic management is often difficult as a result of muscle weakness, hypersensitivity to non-depolarizing neuromuscular blocking agent, and succinylcholine induced hyperkalemia. We describe a 50-year-old patient with type IV SMA for synovectomy. We decided to use an epidural technique to avoid muscle relaxants and tracheal intubation. After operation, there was no exacerbation of neurologic signs and symptoms
    corecore