16 research outputs found
Global embeddings of scalar-tensor theories in (2+1)-dimensions
We obtain (3+3)- or (3+2)-dimensional global flat embeddings of four
uncharged and charged scalar-tensor theories with the parameters B or L in the
(2+1)-dimensions, which are the non-trivially modified versions of the
Banados-Teitelboim-Zanelli (BTZ) black holes. The limiting cases B=0 or L=0
exactly are reduced to the Global Embedding Minkowski Space (GEMS) solution of
the BTZ black holes.Comment: 19 pages, 2 figure
Casimir Effect in 2D Stringy Black Hole Backgrounds
We consider the two-dimensional "Schwarzschild" and "Reissner-Nordstrom"
stringy black holes as systems of Casimir type. We explicitly calculate the
energy-momentum tensor of a massless scalar field satisfying Dirichlet boundary
conditions on two one-dimensional "walls". These results are obtained using the
Wald's axioms. Thermodynamical quantities such as pressure, specific heat,
isothermal compressibility and entropy of the two-dimensional stringy black
holes are calculated. A comparison is made between the obtained results and the
laws of thermodynamics. The results obtained for the extremal (Q=M) stringy
two-dimensional charged black hole are identical in all three different vacua
used; a fact that indicates its quantum stability.Comment: RevTeX, 27 pages, no figures, to appear in Phys.Rev. D, Vol 64 (Dec.
2001
Increased c-kit (CD117) expression in malignant mammary phyllodes tumors
10.1038/modpathol.3800125Modern Pathology177827-831MODP
Tumour Angiogenesis and p53 Protein Expression in Mammary Phyllodes Tumors
10.1097/01.MP.0000089907.67419.42Modern Pathology16101007-1013MODP
Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: A multicenter study of 185 cases
10.1016/j.humpath.2004.01.023Human Pathology3591053-1057HPCQ
Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour
10.1136/jcp.2004.023028Journal of Clinical Pathology586600-604JCPA
Dual universe and hyperboloidal relative velocity surface arising from extended special relativity
A microscopic study of the ground-state properties and excitation spectrum of an interacting Bose system using the combined method relating correlated-basis-functions and the canonical transformations
Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours
Malignant peripheral nerve sheath tumours (MPNSTs) are aggressive soft tissue tumours that occur either sporadically or in patients with neurofibromatosis type 1. The malignant transformation of the benign neurofibroma to MPNST is incompletely understood at the molecular level. We have determined the gene expression signature for benign and malignant PNSTs and found that the major trend in malignant transformation from neurofibroma to MPNST consists of the loss of expression of a large number of genes, rather than widespread increase in gene expression. Relatively few genes are expressed at higher levels in MPNSTs and these include genes involved in cell proliferation and genes implicated in tumour metastasis. In addition, a gene expression signature indicating p53 inactivation is seen in the majority of MPNSTs. Subsequent microRNA profiling of benign and malignant PNSTs indicated a relative down-regulation of miR-34a in most MPNSTs compared to neurofibromas. In vitro studies using the cell lines MPNST-14 (NF1 mutant) and MPNST-724 (from a non-NF1 individual) show that exogenous expression of p53 or miR-34a promotes apoptotic cell death. In addition, exogenous expression of p53 in MPNST cells induces miR-34a and other miRNAs. Our data show that p53 inactivation and subsequent loss of expression of miR-34a may significantly contribute to the MPNST development. Collectively, our findings suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.MTG