An Explorative Study of Creative Idea Generation Using Mobile Collaboration Platform

This study examines creative idea generation within a given task involving the use of a mobile collaboration platform (MCP). Drawing upon the theoretical perspectives on cognitive creativity, mobility, and self-select communication mode, the study proposes a research model that explains how individuals generate creative ideas through MCP use in a group collaboration context. To validate our model, survey data was collected from individuals involved in a group collaboration—particularly when performing tasks that requiring creative solutions. The results of this study indicate that: 1) MCP use has a positive effect on the individual’s creative idea generation; 2) both perceived MCP effectiveness and perceived freedom determine the individual’s MCP use levels; and 3) the individual’s personal innovativeness level in information technology (PIIT) has a conditional effect on the relationship between the perceived MCP freedom and MCP use. The significance of these findings stems from the fact that creative idea generation through group collaboration is a highly sought-after quality in organizational setting. Given the centrality of the mobile ecosystem in today’s organizational task environment, this study presents both theoretical and practical contributions

The Effects and Influential Factors of Employee’s Knowledge Integration Capability in the Convergence Environment

Knowledge integration is becoming a primary function of improving organizational capabilities and performance in today’s convergence environment in which the integration of individual knowledge is the source of organizational knowledge creation for new product and service development. This study investigates the influential factors of employee’s knowledge integration capability and its effects. A theoretical research model was developed based on knowledge creation, socio-technical, and information processing perspectives. In particular, the model proposes a positive relationship between the knowledge integration capability of employees and their knowledge creation output. The model also includes organic organizational structure, teamwork quality, expertise, IT support, and knowledge complexity as the influential factors of an employee’s knowledge integration capability. A large-scale survey was conducted for data gathering (a total of 316 samples from 141 organizations) to test the proposed model. The analysis results of the hypotheses test show that expertise and knowledge complexity are the significant influential factors of employee’s knowledge integration capability. In turn, this capability has a positive effect on the knowledge creation output of employees. The results of this study will contribute to the development of initiatives for promoting knowledge integration in the development processes of convergence products and services

Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling

The dopamine D2 receptor (DRD2) is a key receptor that mediates dopamine-associated brain functions such as mood, reward, and emotion. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit. In this study, we revealed that the serine 321 residue (S321) in the third intracellular loop of DRD2 (D2i3) is a novel regulatory site of Cdk5. Cdk5-dependent phosphorylation of S321 in the D2i3 was observed in in vitro and cell culture systems. We further observed that the phosphorylation of S321 impaired the agonist-stimulated surface expression of DRD2 and decreased G protein coupling to DRD2. Moreover, the downstream cAMP pathway was affected in the heterologous system and in primary neuronal cultures from p35 knockout embryos likely due to the reduced inhibitory activity of DRD2. These results indicate that Cdk5-mediated phosphorylation of S321 inhibits DRD2 function, providing a novel regulatory mechanism for dopamine signaling.X111111sciescopu

Guidewire insertion into the vertebral vein during right internal jugular vein central venous catheterization -A rare case report-

Background Internal jugular veins are the most frequently accessed site for central venous catheterization in patient management, whereas complications involving vertebral veins are a rare occurrence. Case A 73-year-old male suspected to have a urothelial carcinoma was scheduled for elective left nephroureterectomy. During central venous catheterization using the anatomic landmark technique to target the internal jugular vein, a guidewire is inadvertently inserted into the suspected vertebral vein. Following the correction of the catheterization, a radiologist reviewed the preoperative enhanced computed tomography and confirmed that the initially punctured vessel was the vertebral vein. On the third day after surgery, the central venous catheter was removed, and the patient did not exhibit any complications, such as bleeding, swelling, and neurological symptoms. Conclusions The use of ultrasonography during central venous catheterization is recommended to evaluate the anatomy of the puncture site and prevent misinsertion of the catheter, which can lead to several complications

Analysis of Macroscopic Traffic Network Impacted by Structural Damage to Bridges from Earthquakes

Highway systems play a key role in providing mobility to society, especially during emergency situations, including earthquakes. Bridges in highway systems are susceptible to damage from earthquakes, causing traffic capacity loss leading to a serious impact on surrounding areas. To better prepare for such scenarios, it is important to estimate capacity loss and traffic disruptions from earthquakes. For this purpose, a traffic-capacity-analysisbased methodology was developed to model the performance of a transportation network immediately following an earthquake using a macroscopic multi-level urban traffic planning simulation model EMME4. This method employs the second order linear approximation (SOLA) traffic assignment and calculates total system travel time for various capacity loss scenarios due to bridge damage from earthquakes. It has been applied to Pohang City in Korea to evaluate the performance of traffic networks in various situations. The results indicate a significant increase in travel time and a decrease in travel speed as the intensity of an earthquake increases. However, the impact on traffic volume varies depending on the bridges. It is assumed that the location of the bridges and traffic routing patterns might be the main reason. The results are expected to help estimate the impact on transportation networks when earthquakes cause traffic capacity loss on bridges

miR-140-5p suppresses BMP2-mediated osteogenesis in undifferentiated human mesenchymal stem cells

AbstractHuman mesenchymal stem cells (hMSCs) have self-renewal and differentiation capabilities but the regulatory mechanisms of MSC fate determination remain poorly understood. Here, we aimed to identify microRNAs enriched in hMSCs that modulate differentiation commitments. Microarray analysis revealed that miR-140-5p is commonly enriched in undifferentiated hMSCs from various tissue sources. Moreover, bioinformatic analysis and luciferase reporter assay validated that miR-140-5p directly represses bone morphogenic protein 2 (BMP2). Furthermore, blocking miR-140-5p in hMSCs increased the expression of BMP signaling components and critical regulators of osteogenic differentiation. We propose that miR-140-5p functionally inhibits osteogenic lineage commitment in undifferentiated hMSCs

Observation of micro-scale surface morphology with microtexture development during plane strain tensile deformation in AZ31 magnesium alloy

The change of microstructure including microtexture and surface morphology in AZ31 magnesium alloy under plane strain tension was investigated by 3D observation combined confocal microscope and high-resolution electron backscattered diffraction. Micro-scale changes in the surface morphology were observed on the area including tensile twin bands. The mechanism for surface morphology variation was discussed with the nucleation of tensile twinning and the strain partitioning caused by continuing deformation after the nucleation of the twins.open1111sciescopu