6,227 research outputs found
Editorial: water governance in a climate change world: appraising systemic and adaptive effectiveness
and other research outputs Editorial: water governance in a climate change world: appraising systemic and adaptive effectivenes
Oxygen-Vacancy-Induced Orbital Reconstruction of Ti Ions at the Interface of LaAlO3/SrTiO3 Heterostructures: A Resonant Soft-X-Ray Scattering Study
Resonant soft-x-ray scattering measurements have been performed to investigate interface electronic structures of (LaAlO3/SrTiO3) superlattices. Resonant scattering intensities at superlattice reflections show clear evidence of degeneracy lifting in t(2g) states of interface Ti ions. Polarization dependence of intensities indicates the energy of d(xy) states is lower by similar to 1 eV than two other t(2g) states. The energy splitting is insensitive to epitaxial strain. The orbital reconstruction is induced by oxygen vacancies and confined to the interface within two unit cells, indicating charge compensation at the polar interfaces. DOI: 10.1103/PhysRevLett.110.017401X112723Nsciescopu
Solution structure of the dimerization domain of the eurkaryotic stalk P1/P2 complex reveals the structural organization of the eukaryotic stalk
Poster Presentation: abstract A01The lateral ribosomal stalk is responsible for the kingdom‐specific binding of translation factors and activation of GTP hydrolysis during protein synthesis. The eukaryotic stalk consists of the scaffold P0 protein which binds two copies of P1/P2 hetero‐dimers to form a P0(P1/P2)2 pentameric P‐complex. The structure of the eukaryotic stalk is currently not known. To provide a better understanding on the structural organization of eukaryotic stalk, we have determined the solution structure of the N‐terminal dimerization domain …postprin
Nonlinear Sigma Model for Disordered Media: Replica Trick for Non-Perturbative Results and Interactions
In these lectures, given at the NATO ASI at Windsor (2001), applications of
the replicas nonlinear sigma model to disordered systems are reviewed. A
particular attention is given to two sets of issues. First, obtaining
non-perturbative results in the replica limit is discussed, using as examples
(i) an oscillatory behaviour of the two-level correlation function and (ii)
long-tail asymptotes of different mesoscopic distributions. Second, a new
variant of the sigma model for interacting electrons in disordered normal and
superconducting systems is presented, with demonstrating how to reduce it,
under certain controlled approximations, to known ``phase-only'' actions,
including that of the ``dirty bosons'' model.Comment: 25 pages, Proceedings of the NATO ASI "Field Theory of Strongly
Correlated Fermions and Bosons in Low - Dimensional Disordered Systems",
Windsor, August, 2001; to be published by Kluwe
A simple and robust method for connecting small-molecule drugs using gene-expression signatures
Interaction of a drug or chemical with a biological system can result in a
gene-expression profile or signature characteristic of the event. Using a
suitably robust algorithm these signatures can potentially be used to connect
molecules with similar pharmacological or toxicological properties. The
Connectivity Map was a novel concept and innovative tool first introduced by
Lamb et al to connect small molecules, genes, and diseases using genomic
signatures [Lamb et al (2006), Science 313, 1929-1935]. However, the
Connectivity Map had some limitations, particularly there was no effective
safeguard against false connections if the observed connections were considered
on an individual-by-individual basis. Further when several connections to the
same small-molecule compound were viewed as a set, the implicit null hypothesis
tested was not the most relevant one for the discovery of real connections.
Here we propose a simple and robust method for constructing the reference
gene-expression profiles and a new connection scoring scheme, which importantly
allows the valuation of statistical significance of all the connections
observed. We tested the new method with the two example gene-signatures (HDAC
inhibitors and Estrogens) used by Lamb et al and also a new gene signature of
immunosuppressive drugs. Our testing with this new method shows that it
achieves a higher level of specificity and sensitivity than the original
method. For example, our method successfully identified raloxifene and
tamoxifen as having significant anti-estrogen effects, while Lamb et al's
Connectivity Map failed to identify these. With these properties our new method
has potential use in drug development for the recognition of pharmacological
and toxicological properties in new drug candidates.Comment: 8 pages, 2 figures, and 2 tables; supplementary data supplied as a
ZIP fil
The Magic Angle "Mystery" in Electron Energy Loss Spectroscopy: Relativistic and Dielectric Corrections
Recently it has been demonstrated that a careful treatment of both
longitudinal and transverse matrix elements in electron energy loss spectra can
explain the mystery of relativistic effects on the {\it magic angle}. Here we
show that there is an additional correction of order where is
the atomic number and the fine structure constant, which is not
necessarily small for heavy elements. Moreover, we suggest that macroscopic
electrodynamic effects can give further corrections which can break the
sample-independence of the magic angle.Comment: 10 pages (double column), 6 figure
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