204 research outputs found
Fabrication of 1-dimensional nanowires from genetically modified M13 phage through surfactant-mediated hybridization and the applications in medical diagnosis, energy devices, and catalysis
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2010.Vita.Includes bibliographical references.Biological building blocks served as excellent templates for the preparation of various nano-materials due to their beneficial interactions at the molecular level. The bio-mineralization of genetically engineered M13 bacteriophage resulted in one-dimensional nanowires having outstanding properties in diverse applications. As a bridge between the chemical synthesis of nanostructures and the bio-mineralization of M13 phage, surfactant molecules were introduced to the biological systems. The specific affinity of M13 phage with Au-binding peptides was strong enough to attract Au ions despite the existence of surfactant molecules. Consequently, the surfactant-mediated bio-mineralization of M13 phage enabled us to precisely control the morphologies and structures in nanometer scale. The Au-binding M13 phage could also integrate other noble metals (Ag/Pt/Pd) to prepare homogeneous Au-based noble metal alloy nanowires in structures and compositions, and their electrochemical properties upon the systematic changes in compositions were investigated. Especially for the Au-Pt system, the catalytic activity study on the two distinct structures, the alloy and the core/shell, provided us important factors to design new catalysts with optimized activities.by Youjin Lee.Ph.D
Policy effect evaluation under counterfactual neighborhood interventions in the presence of spillover
Policy interventions can spill over to units of a population that are not
directly exposed to the policy but are geographically close to the units
receiving the intervention. In recent work, investigations of spillover effects
on neighboring regions have focused on estimating the average treatment effect
of a particular policy in an observed setting. Our research question broadens
this scope by asking what policy consequences would the treated units have
experienced under hypothetical exposure settings. When we only observe treated
unit(s) surrounded by controls -- as is common when a policy intervention is
implemented in a single city or state -- this effect inquires about the policy
effects under a counterfactual neighborhood policy status that we do not, in
actuality, observe. In this work, we extend difference-in-differences (DiD)
approaches to spillover settings and develop identification conditions required
to evaluate policy effects in counterfactual treatment scenarios. These causal
quantities are policy-relevant for designing effective policies for populations
subject to various neighborhood statuses. We develop doubly robust estimators
and use extensive numerical experiments to examine their performance under
heterogeneous spillover effects. We apply our proposed method to investigate
the effect of the Philadelphia beverage tax on unit sales
RobustIV and controlfunctionIV: Causal Inference for Linear and Nonlinear Models with Invalid Instrumental Variables
We present R software packages RobustIV and controlfunctionIV for causal
inference with possibly invalid instrumental variables. RobustIV focuses on the
linear outcome model. It implements the two-stage hard thresholding method to
select valid instrumental variables from a set of candidate instrumental
variables and make inferences for the causal effect in both low- and
high-dimensional settings. Furthermore, RobustIV implements the
high-dimensional endogeneity test and the searching and sampling method, a
uniformly valid inference method robust to errors in instrumental variable
selection. controlfunctionIV considers the nonlinear outcome model and makes
inferences about the causal effect based on the control function method. Our
packages are demonstrated using two publicly available economic data sets
together with applications to the Framingham Heart Study
Enhanced terahertz conductivity in ultra-thin gold film deposited onto (3-mercaptopropyl) trimethoxysilane (MPTMS)-coated Si substrates
Various material properties change considerably when material is thinned down to nanometer thicknesses. Accordingly, researchers have been trying to obtain homogeneous thin films with nanometer thickness but depositing homogeneous few nanometers thick gold film is challenging as it tends to form islands rather than homogenous film. Recently, studies have revealed that treating the substrate with an organic buffer, (3-mercaptopropyl) trimethoxysilane (MPTMS) enables deposition of ultra-thin gold film having thickness as low as 5 nm. Different aspects of MPTMS treatment for ultrathin gold films like its effect on the structure and optical properties at visible wavelengths have been investigated. However, the effect of the MPTMS treatment on electrical conductivity of ultra-thin gold film at terahertz frequency remains unexplored. Here, we measure the complex conductivity of nanometer-thick gold films deposited onto an MPTMS-coated silicon substrate using terahertz time-domain spectroscopy. Following the MPTMS treatment of the substrate, the conductivity of the films was found to increase compared to those deposited onto uncoated substrate for gold films having the thickness less than 11 nm. We observed 5-fold enhancement in the conductivity for a 7 nm-thick gold film. We also demonstrate the fabrication of nanoslot-antenna arrays in 8.2-nm-thick gold films. The nanoslot-antenna with MPTMS coating has resonance at around 0.5 THz with an electric field enhancement of 44, whereas the nanoslot-antenna without MPTMS coating does not show resonant properties. Our results demonstrate that gold films deposited onto MPTMS-coated silicon substrates are promising advanced materials for fabricating ultra-thin terahertz plasmonic devices
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