Local Identification of Nonparametric and Semiparametric Models

In parametric models a sufficient condition for local identification is that the vector of moment conditions is differentiable at the true parameter with full rank derivative matrix. We show that there are corresponding sufficient conditions for nonparametric models. A nonparametric rank condition and differentiability of the moment conditions with respect to a certain norm imply local identification. It turns out these conditions are slightly stronger than needed and are hard to check, so we provide weaker and more primitive conditions. We extend the results to semiparametric models. We illustrate the sufficient conditions with endogenous quantile and single index examples. We also consider a semiparametric habit-based, consumption capital asset pricing model. There we find the rank condition is implied by an integral equation of the second kind having a one-dimensional null space.Identification, Local identification, Nonparametric models, Asset pricing

Powerful Inference

We develop an inference method for a (sub)vector of parameters identified by conditional moment restrictions, which are implied by economic models such as rational behavior and Euler equations. Building on Bierens (1990), we propose penalized maximum statistics and combine bootstrap inference with model selection. Our method is optimized to be powerful against a set of local alternatives of interest by solving a data-dependent max-min problem for tuning parameter selection. We demonstrate the efficacy of our method by a proof of concept using two empirical examples: rational unbiased reporting of ability status and the elasticity of intertemporal substitution.Comment: 29 pages, 4 figures, 3 table

Local Identification of Nonparametric and Semiparametric Models

In parametric, nonlinear structural models a classical sufficient condition for local identification, like Fisher (1966) and Rothenberg (1971), is that the vector of moment conditions is differentiable at the true parameter with full rank derivative matrix. We derive an analogous result for the nonparametric, nonlinear structural models, establishing conditions under which an infinite-dimensional analog of the full rank condition is sufficient for local identification. Importantly, we show that additional conditions are often needed in nonlinear, nonparametric models to avoid nonlinearities overwhelming linear effects. We give restrictions on a neighborhood of the true value that are sufficient for local identification. We apply these results to obtain new, primitive identification conditions in several important models, including nonseparable quantile instrumental variable (IV) models, single-index IV models, and semiparametric consumption-based asset pricing models

Long Survival after Resection of Small Cell Carcinoma of the Pancreas with Synchronous Adenocarcinoma of the Ampulla of Vater

Small cell carcinoma of the pancreas is very rare and the patient usually died within 1 year after diagnosis. We reported an unusual case with small cell neuroendocrine carcinoma of the pancreas and a synchronous moderately differentiated adenocarcinoma of the ampulla of Vater in a 44-year-old male, who was successfully treated with pylorus-preserving pancreaticoduodenectomy and post-operative cisplatin-based chemoradiation therapy. The follow-up data showed no evidence of recurrence and the patient is in a good health condition at 117 months after the surgery

CCR4 Antagonists in Cutaneous T-Cell Lymphoma (CTCL)

https://openworks.mdanderson.org/sumexp22/1005/thumbnail.jp

Anharmonic Rovibrational Calculations of Singlet Cyclic C4 Using a New Ab Initio Potential and a Quartic Force

We report a CCSD(T)/cc-pCV5Z quartic force field (QFF) and a semi-global CCSD(T)-F12b/aug-cc-pVTZ potential energy surface (PES) for singlet, cyclic C4. Vibrational fundamentals, combinations and overtones are obtained using vibrational second-order perturbation theory (VPT2) and the vibrational configurationinteraction (VCI) approach. Agreement is within 10 cm(exp 1) between the VCI calculated fundamentals on the QFF and PES using the MULTIMODE (MM) program, and VPT2 and VCI results agree for the fundamentals. The agreement between VPT2- QFF and MM-QFF results is also good for the C4 combinations and overtones. The J = 1 and J = 2 rovibrational energies are reported from both VCI (MM) on the PES and VPT2 on the QFF calculations. The spectroscopic constants of (12)C4 and two C(sub 2v)-symmetry, single (13)C-substituted isotopologues are presented, which may help identification of cyclic C4 in future experimental analyses or astronomical observations

Study on behavior incentive mechanism of energy conservation and emission reduction for China freshwater live fish supply chain

Purpose: The purpose of this paper investigates the subject behavior of Energy conservation and emission reduction (ECER) based on structured classification of the organization types of FLF supply chain, and explores reasonable behavior incentive mechanism for ECER of FLF supply chain in China. Design/methodology/approach: This paper classifies the organization subjects of FLF supply chain, and different characteristics of organization subjects are compared in detail. ECER behavior incentive mechanism modeling of FLF supply chain is explored by taking advantage of principal-agent model in view of asymmetry information. Incentives issue of different operating subjects is discussed as enlightenment of the model. Findings: Three types of the organization subjects of FLF supply chain in China have been identified as: loose organization, semi-compact organization and compact organization. Subjects of different types have different abilities to conduct ECER work. Government needs to propose differentiation polices of incentive compensation for different operating subjects, widen the gap of differentiated subsidies/rewards for different investment levels on ECER conducted by different operating subjects of FLF supply chain. Research limitations/implications: It will take long-term unremitting efforts to achieve the target of ECER work for FLF supply chain in China, the dynamic issues and simulation modeling on behavior incentive mechanism of ECER should be developed in future research. Practical implications: Clear understanding of structured classification of the organization subject types of FLF supply chain and the behavior incentive mechanism for ECER, will help government to improve the ECER work in an efficient and effective way. Originality/value: Research to behavior incentive mechanism of ECER has important theoretical value and practical significance. This paper contributes to distinguish three types of operating subjects of FLF supply chain in China, put forward the behavior incentive mechanism of ECER to support the government to improve the ECER work scientifically.Peer Reviewe

Study on behavior incentive mechanism of energy conservation and emission reduction for China freshwater live fish supply chain

Purpose: The purpose of this paper investigates the subject behavior of Energy conservation and emission reduction (ECER) based on structured classification of the organization types of FLF supply chain, and explores reasonable behavior incentive mechanism for ECER of FLF supply chain in China. Design/methodology/approach: This paper classifies the organization subjects of FLF supply chain, and different characteristics of organization subjects are compared in detail. ECER behavior incentive mechanism modeling of FLF supply chain is explored by taking advantage of principal-agent model in view of asymmetry information. Incentives issue of different operating subjects is discussed as enlightenment of the model. Findings: Three types of the organization subjects of FLF supply chain in China have been identified as: loose organization, semi-compact organization and compact organization. Subjects of different types have different abilities to conduct ECER work. Government needs to propose differentiation polices of incentive compensation for different operating subjects, widen the gap of differentiated subsidies/rewards for different investment levels on ECER conducted by different operating subjects of FLF supply chain. Research limitations/implications: It will take long-term unremitting efforts to achieve the target of ECER work for FLF supply chain in China, the dynamic issues and simulation modeling on behavior incentive mechanism of ECER should be developed in future research. Practical implications: Clear understanding of structured classification of the organization subject types of FLF supply chain and the behavior incentive mechanism for ECER, will help government to improve the ECER work in an efficient and effective way. Originality/value: Research to behavior incentive mechanism of ECER has important theoretical value and practical significance. This paper contributes to distinguish three types of operating subjects of FLF supply chain in China, put forward the behavior incentive mechanism of ECER to support the government to improve the ECER work scientifically.Peer Reviewe

Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells

The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection. Epidemic keratoconjunctivitis (EKC), caused by viruses within human adenovirus species D (HAdV-D), is a severe, ocular surface infection associated with corneal inflammation. Clathrin-mediated endocytosis has previously been shown to play a critical role in entry of other HAdV species into many host cell types. However, HAdV-D endocytosis into corneal cells has not been extensively studied. Herein, we show an essential role for cholesterol rich, lipid raft microdomains and caveolin-1, in the entry of HAdV-D37 into primary human corneal fibroblasts. Cholesterol depletion using methyl-β-cyclodextrin (MβCD) profoundly reduced viral infection. When replenished with soluble cholesterol, the effect of MβCD was reversed, allowing productive viral infection. HAdV-D37 DNA was identified in caveolin-1 rich endosomal fractions after infection. Src kinase activity was also increased in caveolin-1 rich endosomal fractions after infection, and Src phosphorylation and CXCL1 induction were both decreased in caveolin-1-/- mice corneas compared to wild type mice. siRNA knock down of caveolin-1 in corneal cells reduced chemokine induction upon viral infection, and caveolin-1-/- mouse corneas showed reduced cellular entry of HAdV-D37. As a control, HAdV-C2, a non-corneal pathogen, appeared to utilize the caveolar pathway for entry into A549 cells, but failed to infect corneal cells entirely, indicating virus and cell specific tropism. Immuno-electron microscopy confirmed the presence of caveolin-1 in HAdV-D37-containing vesicles during the earliest stages of viral entry. Collectively, these experiments indicate for the first time that HAdV-D37 uses a lipid raft mediated caveolin-1 associated pathway for entry into corneal cells, and connects the processes of viral entry with downstream proinflammatory cell signaling