ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury.

The complex molecular microenvironment of the wound bed regulates the duration and degree of inflammation in the wound repair process, while its dysregulation leads to impaired healing. Understanding factors controlling this response provides therapeutic targets for inflammatory disease. Esophageal cancer-related gene 4 (ECRG4) is a candidate chemokine that is highly expressed on leukocytes. We used ECRG4 knockout (KO) mice to establish that the absence of ECRG4 leads to defective neutrophil recruitment with a delay in wound healing. An in vitro human promyelocyte model identified an ECRG4-mediated suppression of the hyaluronic acid receptor, CD44, a key receptor mediating inflammation resolution. In ECRG4 KO mouse leukocytes, there was an increase in CD44 expression, consistent with a model in which ECRG4 negatively regulates CD44 levels. Therefore, we propose a previously unidentified mechanism in which ECRG4 regulates early neutrophil recruitment and subsequent CD44-mediated resolution of inflammation

Value certainty and choice confidence are multidimensional constructs that guide decision-making

The degree of certainty that decision-makers have about their evaluations of available choice alternatives and their confidence about selecting the subjectively best alternative are important factors that affect current and future value-based choices. Assessments of the alternatives in a given choice set are rarely unidimensional; their values are usually derived from a combination of multiple distinct attributes. For example, the taste, texture, quantity, and nutritional content of a snack food may all be considered when determining whether to consume it. We examined how certainty about the levels of individual attributes of an option relates to certainty about the overall value of that option as a whole and/or to confidence in having chosen the subjectively best available option. We found that certainty and confidence are derived from unequally weighted combinations of attribute certainties rather than simple, equal combinations of all sources of uncertainty. Attributes that matter more in determining choice outcomes also are weighted more in metacognitive evaluations of certainty or confidence. Moreover, we found that the process of deciding between two alternatives leads to refinements in both attribute estimations and the degree of certainty in those estimates. Attributes that are more important in determining choice outcomes are refined more during the decision process in terms of both estimates and certainty. Although certainty and confidence are typically treated as unidimensional, our results indicate that they, like value estimates, are subjective, multidimensional constructs

Comparison of health-related quality of life measures in chronic obstructive pulmonary disease

<p>Abstract</p> <p>Background</p> <p>The aims of this study were: (1) to compare the discriminative ability of a disease-specific instrument, the St. George's Respiratory Questionnaire (SGRQ) to generic instruments (i.e., EQ-5D and SF-36); and (2), to evaluate the strength of associations among clinical and health-related quality of life (HRQL) measures in chronic obstructive pulmonary disease (COPD).</p> <p>Methods</p> <p>We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients self-completed two generic HRQL measures (EQ-5D and SF-36) and the disease-specific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease (GOLD) stage was assessed using relative efficiency ratios (REs). Strength of correlation was used to further evaluate associations between clinical and HRQL measures.</p> <p>Results</p> <p>Mean total scores for PCS-36, EQ-VAS and SGRQ were significantly lower for the more severe stages of COPD (<it>p </it>< 0.05). Using SGRQ total score as reference, the summary scores of the generic measures (PCS-36, MCS-36, EQ index, and EQ-VAS) all had REs of <1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance, SGRQ was moderately correlated with FEV₁(<it>r </it>= 0.43), while generic summary scores had trivial levels of correlation with FEV₁(<it>r </it>< 0.2).</p> <p>Conclusions</p> <p>The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health, suggestive that SGRQ may provide COPD studies with greater statistical power than EQ-5D and SF-36 summary scores to capture meaningful differences in clinical severity.</p

An Assessment of Scales Measuring Constructs in Tests of Criminological Theory Based on National Youth Survey Data

Researchers have utilized the National Youth Survey (NYS) data to test a variety of theoretical explanations of criminal behavior. Here, the authors offer an assessment of scales used in tests of criminological theory based on NYS data. The authors conducted this assessment to provide results informing future tests of theory. Their analyses focus on understanding the extent to which scales representative of different theories are actually based on the same item content. They test for two distinct processes that may explain this phenomenon. In the first process, scales measuring a given construct are attributed to different theories. In the second process, scales measuring different constructs are based on the same items. Results show that both of the processes described above contribute to the use of the same NYS items in scales that are attributed to different theories. To inform future tests of theory, the authors identify the sections of the NYS where each of these processes are most prevalent, in effect identifying the areas of the NYS that future tests of theory should treat with the greatest care. Based on the implications of each process identified above, the authors also offer some suggestions to strengthen future tests of theory using NYS data