6,089 research outputs found
Classification of Radiology Reports Using Neural Attention Models
The electronic health record (EHR) contains a large amount of
multi-dimensional and unstructured clinical data of significant operational and
research value. Distinguished from previous studies, our approach embraces a
double-annotated dataset and strays away from obscure "black-box" models to
comprehensive deep learning models. In this paper, we present a novel neural
attention mechanism that not only classifies clinically important findings.
Specifically, convolutional neural networks (CNN) with attention analysis are
used to classify radiology head computed tomography reports based on five
categories that radiologists would account for in assessing acute and
communicable findings in daily practice. The experiments show that our CNN
attention models outperform non-neural models, especially when trained on a
larger dataset. Our attention analysis demonstrates the intuition behind the
classifier's decision by generating a heatmap that highlights attended terms
used by the CNN model; this is valuable when potential downstream medical
decisions are to be performed by human experts or the classifier information is
to be used in cohort construction such as for epidemiological studies
Report of the ultraviolet and visible sensors panel
In order to meet the science objectives of the Astrotech 21 mission set the Ultraviolet (UV) and Visible Sensors Panel made a number of recommendations. In the UV wavelength range of 0.01 to 0.3 micro-m the focus is on the need for large format high quantum efficiency, radiation hard 'solar-blind' detectors. Options recommended for support include Si and non-Si charge coupled devices (CCDs) as well as photocathodes with improved microchannel plate readouts. For the 0.3 to 0.9 micro-m range, it was felt that Si CCDs offer the best option for high quantum efficiencies at these wavelengths. In the 0.9 to 2.5 micro-m the panel recommended support for the investigation of monolithic arrays. Finally, the panel noted that the implementation of very large arrays will require new data transmission, data recording, and data handling technologies
Optically controlled spin-glasses in multi-qubit cavity systems
Recent advances in nanostructure fabrication and optical control, suggest
that it will soon be possible to prepare collections of interacting two-level
systems (i.e. qubits) within an optical cavity. Here we show theoretically that
such systems could exhibit novel phase transition phenomena involving
spin-glass phases. By contrast with traditional realizations using magnetic
solids, these phase transition phenomena are associated with both matter and
radiation subsystems. Moreover the various phase transitions should be tunable
simply by varying the matter-radiation coupling strength.Comment: 4 pages, 3 figure
The Stellar Metallicity Distribution Function of the Galactic Halo from SDSS Photometry
We explore the stellar metallicity distribution function of the Galactic halo
based on SDSS ugriz photometry. A set of stellar isochrones is calibrated using
observations of several star clusters and validated by comparisons with
medium-resolution spectroscopic values over a wide range of metal abundance. We
estimate distances and metallicities for individual main-sequence stars in the
multiply scanned SDSS Stripe 82, at heliocentric distances in the range 5 - 8
kpc and |b| > 35 deg, and find that the in situ photometric metallicity
distribution has a shape that matches that of the kinematically-selected local
halo stars from Ryan & Norris. We also examine independent kinematic
information from proper-motion measurements for high Galactic latitude stars in
our sample. We find that stars with retrograde rotation in the rest frame of
the Galaxy are generally more metal poor than those exhibiting prograde
rotation, which is consistent with earlier arguments by Carollo et al. that the
halo system comprises at least two spatially overlapping components with
differing metallicity, kinematics, and spatial distributions. The observed
photometric metallicity distribution and that of Ryan & Norris can be described
by a simple chemical evolution model by Hartwick (or by a single Gaussian
distribution); however, the suggestive metallicity-kinematic correlation
contradicts the basic assumption in this model that the Milky Way halo consists
primarily of a single stellar population. When the observed metallicity
distribution is deconvolved using two Gaussian components with peaks at [Fe/H]
~ -1.7 and -2.3, the metal-poor component accounts for ~20% - 35% of the entire
halo population in this distance range.Comment: Accepted for publication in Ap
Observations of X-rays and Thermal Dust Emission from the Supernova Remnant Kes 75
We present Spitzer Space Telescope and Chandra X-ray Observatory observations
of the composite Galactic supernova remnant Kes 75 (G29.7-0.3). We use the
detected flux at 24 microns and hot gas parameters from fitting spectra from
new, deep X-ray observations to constrain models of dust emission, obtaining a
dust-to-gas mass ratio M_dust/M_gas ~0.001. We find that a two-component
thermal model, nominally representing shocked swept-up interstellar or
circumstellar material and reverse-shocked ejecta, adequately fits the X-ray
spectrum, albeit with somewhat high implied densities for both components. We
surmise that this model implies a Wolf-Rayet progenitor for the remnant. We
also present infrared flux upper limits for the central pulsar wind nebula.Comment: 7 pages, 2 tables, 4 figures, uses emulateapj. Accepted for
publication in Ap
Spray and combustion characteristics of acetone-butanol-ethanol and diesel in a constant volume chamber and a diesel engine
Recent research has shown that butanol, instead of ethanol, has the potential of introducing a more suitable blend in diesel engines. This is because butanol has properties similar to current transportation fuels in comparison to ethanol. However, the main downside is the high cost of the butanol production process. Acetone-butanol-ethanol (ABE) is an intermediate product of the fermentation process of butanol production. By eliminating the separation and purification processes, using ABE directly in diesel blends has the potential of greatly decreasing the overall cost for fuel production. This could lead to a vast commercial use of ABE-diesel blends on the market. Research has been done in the past five years concerning spray and combustion processes of both neat ABE and ABE-diesel mixtures. Additionally, different compositions of ABE mixtures had been characterized with a similar experimental approach.
This thesis reviews the production of ABE and characterization of its spray and combustion processes. The results obtained during the recent four years will also be presented. The main focus of this paper is to review the efforts made in fundamental spray research under quasi-steady flow field environments provided by a high-pressure, high-temperature constant volume chamber. In-cylinder pressure traces were calculated to derive apparent heat release rates, high-speed Mie-scattering images were acquired to characterize liquid spray penetration, and natural flame luminosity was also captured to depict spatial and temporal soot distribution. It is observed that the acetone content has a major influence in the combustion behavior of the ABE mixture. An increased content of acetone will lead to a significantly advanced combustion phasing. Butanol, as another important species in the ABE mixture, is able to compensate the advancing effect caused by acetone and ethanol. More importantly, butanol can increase the overall energy density of the mixture, which makes the property of the mixture closer to that of current transportation fuels. In addition, the underlying challenges faced in this area of research are described.
Additionally, the performance and emissions of acetone-butanol-ethanol (ABE)/diesel mixtures in an AVL 5402 single cylinder diesel research engine under various engine operating conditions were investigated in this study. The experiments were conducted at three different speeds (1200, 1500, and 2000 RPM) and different injection quantities (loads) (15, 20, and 25 mg/cycle).
The fuels tested in these experiments were pure diesel, ABE10, and ABE20. The acetone-butanol-ethanol (ABE) was blended in a 3:6:1 ratio. ABE10 and ABE20 consist of 10% acetone-butanol-ethanol mixture and 90% diesel by volume and 20% ABE is mixed with 80% diesel by volume, respectively.
The results showed a promising future for ABE-diesel mixtures as an alternative transportation fuel. There was improved thermal efficiency even with relatively small ABE blending ratios and a slight reduction in power output due to the lower energy density. There was an overall retarded combustion phasing, including longer ignition delay time, retarded CA50 timing, peak pressure timing, and end of combustion timing. Accelerated heat release during CA10~CA50 indicates a higher degree of premixed combustion. Overall soot emissions were lower and NOx emissions were higher for ABE-containing fuels at the same load and timing conditions. Tuning the injection timing would be helpful for the reduction of NOx to a degree that is even lower than that of diesel.
With proper tuning of the injection quantity and injection timing, adopting ABE-diesel mixtures has the potential of improving efficiency and reducing emissions at the same time. Considering the low cost of ABE production compared to other kinds of bio-fuels, ABE could become a possible alternative to the current fuel additives
Metallicity Mapping with gri Photometry: The Virgo Overdensity and the Halos of the Galaxy
We describe the methodology required for estimation of photometric estimates
of metallicity based on the SDSS gri passbands, which can be used to probe the
properties of main-sequence stars beyond ~ 10 kpc, complementing studies of
nearby stars from more metallicity-sensitive color indices that involve the u
passband. As a first application of this approach, we determine photometric
metal abundance estimates for individual main-sequence stars in the Virgo
Overdensity, which covers almost 1000 square degrees on the sky, based on a
calibration of the metallicity sensitivity of stellar isochrones in the gri
filter passbands using field stars with well-determined spectroscopic metal
abundances. Despite the low precision of the method for individual stars,
internal errors of in [Fe/H] ~ +/- 0.1 dex can be achieved for bulk stellar
populations. The global metal abundance of the Virgo Overdensity determined in
this way is = -2.0 +/- 0.1 (internal) +/- 0.5 (systematic), from
photometric measurements of 0.7 million stars with heliocentric distances from
~ 10 kpc to ~ 20 kpc. A preliminary metallicity map, based on results for 2.9
million stars in the northern SDSS DR-7 footprint, exhibits a shift to lower
metallicities as one proceeds from the inner- to the outer-halo population,
consistent with recent interpretation of the kinematics of local samples of
stars with spectroscopically available metallicity estimates and full space
motions.Comment: 4 pages, 2 figures, to appear in IAU Symp. 26
Direct imaging of single UvrD helicase dynamics on long single-stranded DNA
Fluorescence imaging of single-protein dynamics on DNA has been largely limited to double-stranded DNA or short single-stranded DNA. We have developed a hybrid approach for observing single proteins moving on laterally stretched kilobase-sized ssDNA. Here we probed the single-stranded DNA translocase activity of Escherichia coli UvrD by single fluorophore tracking, while monitoring DNA unwinding activity with optical tweezers to capture the entire sequence of protein binding, single-stranded DNA translocation and multiple pathways of unwinding initiation. The results directly demonstrate that the UvrD monomer is a highly processive single-stranded DNA translocase that is stopped by a double-stranded DNA, whereas two monomers are required to unwind DNA to a detectable degree. The single-stranded DNA translocation rate does not depend on the force applied and displays a remarkable homogeneity, whereas the unwinding rate shows significant heterogeneity. These findings demonstrate that UvrD assembly state regulates its DNA helicase activity with functional implications for its stepping mechanism, and also reveal a previously unappreciated complexity in the active species during unwinding
Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis
A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as low as 500 ppm catalyst loadings. RCM of the five-membered carbamate series could be run neat, the six-membered carbamate series could be run at 1.0 M, and the seven-membered carbamate series worked best at 0.2−0.05 M
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