193 research outputs found
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A Qualitative Analysis of the Impact of Popular Culture on Destination Image: A Case Study of Korean Wave from Japanese Fans
The purpose of the research was to investigate how a countryās popular culture impacts its destination image through a case study. For this purpose, the research indentified the characteristics of pop-star fans in this study. The study explored the phenomenon of the Korean wave through a case of a pop-star and his fans. Lastly, the study examined destination image perspectives and experiences of the pop-star fans who attended the pop-starās summer camp. The research found that popular culture is a significant agent of Koreaās recent image. The study also revealed that the respondentsā high level of interest and empathy for the pop-star was a key reason for their visiting in the destination and changing their perception
Influence of Waist Circumference Measurement Site on Visceral Fat and Metabolic Risk in Youth
Although the rate of childhood obesity seems to have plateaued in recent years, the prevalence of obesity among children and adolescents remains high. Childhood obesity is a major public health concern as overweight and obese youth suffer from many co-morbid conditions once considered exclusive to adults. It is now well demonstrated that abdominal obesity as measured by waist circumference (WC) is an independent risk factor for cardiovascular disease and metabolic dysfunction in youth. Despite the strong associations between WC and cardiometabolic risk factors, there is no consensus regarding the optimal WC measurement sites to assess abdominal obesity and obesity-related health risk in children and adolescents. Currently, the WC measurement site that provides the best reflections of visceral fat and the best correlations with cardiometabolic risk factors is unclear. The purpose of this review is to explore whether WC measurement sites influence the relationships between WC, visceral fat, and cardiometabolic risk factors in children and adolescents
Depressive symptoms and metabolic markers of risk for type 2 diabetes in obese adolescents
OBJECTIVE:
Although higher rates of depression are found among individuals with type 2 diabetes, it remains unknown if the presence of depressive symptoms is associated with heightened metabolic risk for the development of type 2 diabetes among youth. The objective of this study was to evaluate whether depressive symptoms in obese adolescents are associated with impaired Ī²-cell function relative to insulin sensitivity [oral disposition index (oDI)] and/or dysglycemia or prediabetes, predictors of type 2 diabetes development.
RESEARCH DESIGN AND METHODS:
Fasting and oral glucose tolerance test (OGTT)-derived indices of glucose tolerance, insulin sensitivity, secretion, and oDI were evaluated in obese youth (nā=ā56, age 15.0āĀ±ā1.6āyr, 68% female). The Children's Depression Inventory was utilized to determine depressive symptomatology.
RESULTS:
Despite no association between depressive symptoms and measures of adiposity, youth with higher depressive symptoms had (i) significantly higher fasting and stimulated glucose levels (13% higher glucose area under the OGTT curve), (ii) ā¼50% lower oDI, and (iii) a 50% frequency of prediabetes.
CONCLUSIONS:
These data point to an important relationship between depressive symptoms and a heightened metabolic risk for type 2 diabetes in obese adolescents, including prediabetes and impairment in Ī²-cell function relative to insulin sensitivity. While the directionality of these relationships is unknown, it should be determined if treating one disorder improves the other or vice versa
Self-Supervised Pre-Training for Precipitation Post-Processor
Obtaining a sufficient forecast lead time for local precipitation is
essential in preventing hazardous weather events. Global warming-induced
climate change increases the challenge of accurately predicting severe
precipitation events, such as heavy rainfall. In this paper, we propose a deep
learning-based precipitation post-processor for numerical weather prediction
(NWP) models. The precipitation post-processor consists of (i) employing
self-supervised pre-training, where the parameters of the encoder are
pre-trained on the reconstruction of the masked variables of the atmospheric
physics domain; and (ii) conducting transfer learning on precipitation
segmentation tasks (the target domain) from the pre-trained encoder. In
addition, we introduced a heuristic labeling approach to effectively train
class-imbalanced datasets. Our experiments on precipitation correction for
regional NWP show that the proposed method outperforms other approaches.Comment: 7 pages, 3 figures, 1 table, accepted to NeurIPS 2023 Workshop on
Tackling Climate Change with Machine Learning at [this http
URL](https://www.climatechange.ai/papers/neurips2023/18
Whole-Body MRI and Ethnic Differences in Adipose Tissue and Skeletal Muscle Distribution in Overweight Black and White Adolescent Boys
It is unclear whether ethnic differences exist in adipose tissue (AT) and skeletal muscle (SM) distribution in black and white youth. Investigation into the pattern of AT and SM distribution in black versus white youth may provide insight into the previously reported health disparities between these ethnicities. Therefore, we examined total and regional AT and SM in overweight black and white boys. The study sample included overweight black (n = 19) and white (n = 21) boys (11ā18 yr, BMI ā„ 85th) whose body composition was evaluated using whole-body MRI. Despite similar age, Tanner stage, and BMI, black boys had significantly (P < .05) less visceral AT than white boys and more (P < .05) total and lower-body subcutaneous AT (SAT) in both absolute (kg) and relative (%) terms. There was a main effect (P < .05) of ethnicity on the relationship between total and regional AT, such that for a given amount of total body AT (kg), black boys had a greater (P < .05) lower-body SAT and less visceral AT than their white peers. For a given amount of total SM, black boys had more (P < .05) SM in the thigh. Compared with overweight white boys, overweight black boys have less visceral fat, more subcutaneous fat, and more thigh skeletal muscle
Epidemiology, burden and clinical spectrum of cluster headache: a global update
Disability; Economic and job-related burdens; Quality of lifeDiscapacidad; Cargas econĆ³micas y laborales; Calidad de vidaDiscapacitat; CĆ rregues econĆ²miques i laborals; Qualitat de vidaBackground
This narrative review aims to broaden our understanding of the epidemiology, burden and clinical spectrum of cluster headache based on updated findings with a global perspective.
Methods
We conducted a literature search on the following topics: (a) epidemiology; (b) burden: quality of life, disability, economic burden, job-related burden and suicidality; and (c) clinical spectrum: male predominance and its changes, age, pre-cluster and pre-attack symptoms, aura, post-drome, attack characteristics (location, severity, duration and associated symptoms), bout characteristics (attack frequency, bout duration and bout frequency), circadian and seasonal rhythmicity and disease course.
Results
New large-scale population-based reports have suggested a lower prevalence than previous estimations. The impact of cluster headache creates a significant burden in terms of the quality of life, disability, economic and job-related burdens and suicidality. Several studies have reported decreasing male-to-female ratios and a wide age range at disease onset. The non-headache phases of cluster headache, including pre-cluster, pre-attack and postictal symptoms, have recently been revisited. The latest data regarding attack characteristics, bout characteristics, and circadian and seasonal rhythmicity from different countries have shown variability among bouts, attacks, individuals and ethnicities. Studies on the disease course of cluster headache have shown typical characteristics of attacks or bouts that decrease with time.
Conclusions
Cluster headache may be more than a ātrigeminal autonomic headacheā because it involves complex central nervous system phenomena. The spectrum of attacks and bouts is wider than previously recognised. Cluster headache is a dynamic disorder that evolves or regresses over time.This study was supported by the New Faculty Start-up Fund of Seoul National University and National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP; No. 2020R1A2B5B01001826)
Pre-diabetes in overweight youth and early atherogenic risk
PURPOSE: To compare atherogenic lipoprotein particles and vascular smooth muscle biomarkers in overweight youth with pre-diabetes (PD) vs. normal glucose tolerance (NGT).
METHODS: 144 adolescents (60 black, 84 white; 102 female; PD=45, NGT=99) aged 10-19 years underwent a fasting blood draw and 2-h OGTT. Lipoprotein particle size and subclass concentration and vascular smooth muscle biomarkers (ICAM-1, VCAM-1 and E-selectin) were compared between youth with PD and NGT.
RESULTS: Compared with NGT, PD adolescents had smaller LDL (meanĀ±SE: 20.5Ā±0.1 vs. 21.0Ā±0.1 nm; P=0.002) and HDL (8.62Ā±0.05 vs. 8.85Ā±0.04 nm; P=0.013) size and elevated medium small (159.2Ā±10.3 vs. 123.8Ā±6.4 nmol/L; P=0.037) and very small (626.3Ā±45.4 vs. 458.5Ā±26.4 nmol/L; P=0.032) LDL particle concentrations, after adjustment for race and BMI. Further adjusting for fasting insulin or visceral adiposity obviated these differences between the groups except for LDL size. ICAM-1 and E-selectin did not differ in youth with PD but correlated with LDL and HDL size, and small LDL particle concentrations.
CONCLUSIONS: Overweight adolescents with PD have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, moderated by insulin resistance and visceral adiposity, but independently driven by dysglycemia for LDL size. Associations between smooth muscle biomarkers and lipoproteins could be an early signal heralding the atherogenic process. It remains to be determined if correction of dysglycemia and associated lipoprotein abnormalities in obese youth could prove effective in halting this process
25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and b-Cell Function Relative to Insulin Sensitivity in Black and White Youth
OBJECTIVE
To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and Ī²-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth.
RESEARCH DESIGN AND METHODS
Plasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had existing data on hyperinsulinemic-euglycemic and hyperglycemic clamp to assess insulin sensitivity and secretion, and measurements of body composition, and abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT).
RESULTS
A total of 183 research volunteers (mean Ā± SD; age, 12.6 Ā± 2.2 years; 98 white, 98 male, 92 obese) were studied. Analysis of HbA1c, fasting glucose and insulin, insulin sensitivity, and DI across quartiles of plasma 25(OH)D revealed no differences among whites. In blacks, the observed significance of higher insulin sensitivity and DI in the highest quartile of 25(OH)D disappeared after adjusting for any of the adiposity measures (BMI or fat mass or VAT or SAT). The difference in insulin sensitivity (9.4 Ā± 1.2 vs. 5.6 Ā± 0.5 mg/kg/min per Ī¼U/mL; P = 0.006) between 25(OH)D nondeficient (ā„20 ng/mL) versus deficient (<20 ng/mL) black youth also was negated when adjusted for adiposity.
CONCLUSIONS
In healthy youth, plasma 25(OH)D concentrations bear no independent relationship to parameters of glucose homeostasis and in vivo insulin sensitivity and Ī²-cell function relative to insulin sensitivity. It remains to be determined whether in youth with dysglycemia the relationships are different and whether vitamin D optimization enhances insulin sensitivity and Ī²-cell function.This work was supported by U.S. Public Health Service Grant RO1 HD27503 (S.A.A.), K24 HD01357 (S.A.A.), Richard L. Day Endowed Chair (S.A.A.), K23 HD052550 (K.R.), 1UL1RR025771 CTSI, and UL1 RR024153 CTSA (previously MO1 RR00084 GCRC)
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