THE EFFECT OF ACUTE BEETROOT JUICE SUPPLEMENTATION ON MUSCLE FATIGUE IN KNEE EXTENSOR EXERCISE

To examine the effect of acute beetroot juice supplementation on the rate of fatigue as measured by changes in peak torque. Placebo-controlled, double-blind, cross-over study, 35 recreationally active subjects consumed beetroot (BR) juice or black currant juice (PL) 12 and 2.5 hours before the exercise procedure. Peak torque was measured on the BIODEX dynamometer by performing 50, maximal effort, concentric knee extensions at 90°/s. Blood pressure (BP) was recorded before and after exercise. No significant difference between BR and PL in the rate of fatigue measured by change in peak torque. By stage 3, subjects retained 87.6±6.9% of strength with BR and 86.7±6.3% with PL (p= 0.363). Stages 10 was as follows: BR 47.9±12.6 vs. PL 46.9±12.9% (p= 0.419). The rate of work fatigue showed no significant differences. By stage 4, mean percent work fatigue showed 20.6±9% with BR and 21.8±10.1% with PL (p= 0.224). Stage 10 was as follows: BR 52.5±12.6% vs. PL 53.2±13% (p= 0.571). Post-exercise diastolic BP (BR: 67.2±9.8 vs. PL: 64.5±7.9mmHg, p= 0.039) and MAP (BR: 91.6±9.3 vs. PL: 88.8±8.2mmHg, p= 0.011) were higher with BR supplementation. Acute bouts of beetroot juice supplementation had no significant effect on knee extensor muscle fatigue measured during isokinetic contraction

Improvement of Stability of a Grid-Connected Inverter with an LCL filter by Robust Strong Active Damping and Model Predictive Control

This study addresses development and implementation of robust control methods for a three-phase grid-connected voltage source inverter (VSI) accompanied by an inductive-capacitive-inductive (LCL) filter. A challenge of current control for the VSI is LCL filter resonance near to the control stability boundary, which interacts with the inverter control switching actions and creates the possibility of instability. In general, active damping is needed to stabilize the system and ensure robust performance in steady-state and dynamic responses. While many active damping methods have been proposed to resolve this issue, capacitor-current-feedback active damping has been most widely used for its simple implementation. There has been no clear consensus regarding design of a control system including capacitor-current-feedback active damping. This is due to the fact that simulation/experiment results are not congruent with the design analyses on which the control is designed. This study explains the incoherence between theory and practice when it comes to a capacitor-currents-feedback active damping system. Proposed capacitor-current-estimate active damping utilizing a developed posteriori Kalman estimator gives coherent simulation results as expected from the design analyses. This reveals that the highly oscillatory capacitor currents containing the inverter switching effects bring about uncertainty in the system performance. The switching effects are not incorporated in the analyses and control system design. Therefore, it is required to remove the switching noise from the capacitor currents in order to yield consistent results. It has been confirmed that the proportional-negative feedback of the capacitor current is equivalent to virtual impedance connected in parallel with the filter capacitor. In a digitally controlled system, the computation delay causes the equivalent resistance of the virtual impedance to become negative in the frequency range of fs/6 to fs/2, which produces a pair of open-loop unstable poles in RHP. This happens when the displaced resonance peak by active damping is in that region. Thus, an a priori Kalman estimator has been developed to generate one-sample-ahead state variable estimates to reconstruct the capacitor currents for active damping, which can compensate for the delay. The one-sample-ahead capacitor-current estimates are computed from the inverter-side and grid-side current estimates. The proposed method provides extended limits of the active damping gain that improve robustness against system parameter variation. It also allows strong active damping which can sufficiently attenuate the resonance. Grid condition is another significant factor affecting the stability of the system. In particular, a weak grid tends to provide high impedance. The system employing the proposed active damping method stably operates in a weak grid, ensuring robustness under grid impedance variation. The developed Kalman estimators offer an effective and easy way of determining the stability status of a system in addition to the functions of filtering and estimation. Stability analysis can be easily made since state variable estimates go to infinity when a system is unstable. As a promising approach, model predictive control (MPC) has been designed for the system. This study suggests that MPC including active damping can be employed for a grid-connected VSI with an LCL filter with good dynamic performance

Neurovascular Interaction and Exercise Training for Bone Regeneration

The nervous and vascular systems are widely distributed in the skeletal system and play an important role in bone metabolism and bone formation, respectively. Their independent impact on the skeletal system has received keen attention in bone-related research over the decade. However, the mechanism of neurovascular coupling during physiological bone remodeling and regeneration has recently been highlighted, considering the importance of spatial relationships between bone-associated skeletal nerves and blood vessels. In addition, the positive effect of exercise on the bones has been continuously emphasized, as evident by the improved number and function of skeletal nerves and blood vessels following exercise training. Skeletal nerve-vascular crosstalk and exercise training are essential for bone development and regeneration, respectively; however, the effect of exercise on neurovascular interactions has not yet been studied. This review aims to summarize the regulatory roles of the nerves and blood vessels in bone metabolism and regeneration and to highlight a combination of potential cellular processes of neurogenesis and angiogenesis in bone regeneration. Moreover, given the significance of the spatial relationship between nerves and blood vessels in bones and the role of exercise training, this review aims to discuss the potential physiological neurovascular coupling that occurs following exercise and physical activity

The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal Nerves

: The spatial distribution, innervation, and functional role of the bone-associated skeletal nerves have been previously reported in detail. However, studies examining exercise-induced associations between skeletal nerves and bone metabolism are limited. This review introduces a potential relationship between exercise and the skeletal nerves and discusses how it can contribute to exercise-induced bone anabolism. First, the background and current understanding of nerve fiber types and their functions in the skeleton are provided. Next, the influence of exercise and mechanical loading on the skeletal nervous system is elaborated. Effective synthesis of recent studies could serve as an established baseline for the novel discovery of the effects of exercise on skeletal nerve density and bone anabolic activity in the future. Therefore, this review overviews the existing evidence for the neural control of bone metabolism and the potential positive effects of exercise on the peripheral skeletal nervous system. The influence of exercise training models on the relationships of sensory nerve signals with osteoblast-mediated bone formation and the increased bone volume provides the first insight on the potential importance of exercise training in stimulating positive adaptations in the skeletal nerve-bone interaction and its downstream effect on bone metabolism, thereby highlighting its therapeutic potential in a variety of clinical populations

Differentiable Display Photometric Stereo

Photometric stereo leverages variations in illumination conditions to reconstruct per-pixel surface normals. The concept of display photometric stereo, which employs a conventional monitor as an illumination source, has the potential to overcome limitations often encountered in bulky and difficult-to-use conventional setups. In this paper, we introduce Differentiable Display Photometric Stereo (DDPS), a method designed to achieve high-fidelity normal reconstruction using an off-the-shelf monitor and camera. DDPS addresses a critical yet often neglected challenge in photometric stereo: the optimization of display patterns for enhanced normal reconstruction. We present a differentiable framework that couples basis-illumination image formation with a photometric-stereo reconstruction method. This facilitates the learning of display patterns that leads to high-quality normal reconstruction through automatic differentiation. Addressing the synthetic-real domain gap inherent in end-to-end optimization, we propose the use of a real-world photometric-stereo training dataset composed of 3D-printed objects. Moreover, to reduce the ill-posed nature of photometric stereo, we exploit the linearly polarized light emitted from the monitor to optically separate diffuse and specular reflections in the captured images. We demonstrate that DDPS allows for learning display patterns optimized for a target configuration and is robust to initialization. We assess DDPS on 3D-printed objects with ground-truth normals and diverse real-world objects, validating that DDPS enables effective photometric-stereo reconstruction

The Impact of Aspirin Intake on Lactate Dehydrogenase, Arterial Stiffness, and Oxidative Stress During High-Intensity Exercise: A Pilot Study

Aspirin is a common nonsteroidal anti-inflammatory drug used to reduce fever, pain, and inflammation. However, aspirin\u27s anti-inflammatory properties may also prevent increased levels of blood lactate dehydrogenase, vascular arterial stiffness and oxidative stress induced by high-intensity exercise. The purpose of this study was to investigate the effects of 4 weeks of aspirin supplementation on lactate dehydrogenase activity, lactate, arterial stiffness, and antioxidant capacity during high-intensity exercise in Taekwondo athletes. Participants were randomly divided into two groups: aspirin supplementation (n = 10) and placebo-control (n = 10). Blood levels of lactate dehydrogenase (LDH) enzyme activity and lactate were assessed to examine muscle damage and carotid-to-radial pulse wave velocity and the augmentation index were measured to examine arterial stiffness. Blood levels of superoxide dismutase, malondialdehyde, and glutathione peroxidase were assessed to determine antioxidant capacity and levels of oxidative stress. There were significant group × time interactions for enzyme activity of LDH (Δ-60 ± 24.36 U/L) and carotid-to-radial pulse wave velocity (Δ-1.33 ± 0.54 m/s), which significantly decreased (p \u3c 0.05) following aspirin supplementation compared to placebo-control. Superoxide dismutase (Δ359 ± 110 U/gHb) and glutathione peroxidase (Δ28.2 ± 10.1 U/gHb) significantly decreased while malondialdehyde (0Δ3.0 ± 0.1 mmol/mL) significantly increased (p \u3c 0.05) in the placebo-control group compared to the supplementation group. However, there were no changes in lactate concentration levels or augmentation index. These results reveal that low-dose aspirin supplementation would be a useful supplementation therapy to prevent high-intensity exercise training-induced increases in oxidative damage, inflammation, skeletal muscle fatigue, and arterial stiffness in elite Taekwondo athletes