Analytic Formulation and Numerical Implementation of an Acoustic Pressure Gradient Prediction

The scattering of rotor noise is an area that has received little attention over the years, yet the limited work that has been done has shown that both the directivity and intensity of the acoustic field may be significantly modified by the presence of scattering bodies. One of the inputs needed to compute the scattered acoustic field is the acoustic pressure gradient on a scattering surface. Two new analytical formulations of the acoustic pressure gradient have been developed and implemented in the PSU-WOPWOP rotor noise prediction code. These formulations are presented in this paper. The first formulation is derived by taking the gradient of Farassat's retarded-time Formulation 1A. Although this formulation is relatively simple, it requires numerical time differentiation of the acoustic integrals. In the second formulation, the time differentiation is taken inside the integrals analytically. The acoustic pressure gradient predicted by these new formulations is validated through comparison with the acoustic pressure gradient determined by a purely numerical approach for two model rotors. The agreement between analytic formulations and numerical method is excellent for both stationary and moving observers case

Analytic Formulation and Numerical Implementation of an Acoustic Pressure Gradient Prediction

Two new analytical formulations of the acoustic pressure gradient have been developed and implemented in the PSU-WOPWOP rotor noise prediction code. The pressure gradient can be used to solve the boundary condition for scattering problems and it is a key aspect to solve acoustic scattering problems. The first formulation is derived from the gradient of the Ffowcs Williams-Hawkings (FW-H) equation. This formulation has a form involving the observer time differentiation outside the integrals. In the second formulation, the time differentiation is taken inside the integrals analytically. This formulation avoids the numerical time differentiation with respect to the observer time, which is computationally more efficient. The acoustic pressure gradient predicted by these new formulations is validated through comparison with available exact solutions for a stationary and moving monopole sources. The agreement between the predictions and exact solutions is excellent. The formulations are applied to the rotor noise problems for two model rotors. A purely numerical approach is compared with the analytical formulations. The agreement between the analytical formulations and the numerical method is excellent for both stationary and moving observer cases

Into-TTS : Intonation Template based Prosody Control System

Intonations take an important role in delivering the intention of the speaker. However, current end-to-end TTS systems often fail to model proper intonations. To alleviate this problem, we propose a novel, intuitive method to synthesize speech in different intonations using predefined intonation templates. Prior to the acoustic model training, speech data are automatically grouped into intonation templates by k-means clustering, according to their sentence-final F0 contour. Two proposed modules are added to the end-to-end TTS framework: intonation classifier and intonation encoder. The intonation classifier recommends a suitable intonation template to the given text. The intonation encoder, attached to the text encoder output, synthesizes speech abiding the requested intonation template. Main contributions of our paper are: (a) an easy-to-use intonation control system covering a wide range of users; (b) better performance in wrapping speech in a requested intonation with improved pitch distance and MOS; and (c) feasibility to future integration between TTS and NLP, TTS being able to utilize contextual information. Audio samples are available at https://srtts.github.io/IntoTTS.Comment: Submitted to INTERSPEECH 202

Evolutionary coupling analysis identifies the impact of disease-associated variants at less-conserved sites

Genome-wide association studies have discovered a large number of genetic variants in human patients with the disease. Thus, predicting the impact of these variants is important for sorting disease-associated variants (DVs) from neutral variants. Current methods to predict the mutational impacts depend on evolutionary conservation at the mutation site, which is determined using homologous sequences and based on the assumption that variants at well-conserved sites have high impacts. However, many DVs at less-conserved but functionally important sites cannot be predicted by the current methods. Here, we present a method to find DVs at less-conserved sites by predicting the mutational impacts using evolutionary coupling analysis. Functionally important and evolutionarily coupled sites often have compensatory variants on cooperative sites to avoid loss of function. We found that our method identified known intolerant variants in a diverse group of proteins. Furthermore, at less-conserved sites, we identified DVs that were not identified using conservation-based methods. These newly identified DVs were frequently found at protein interaction interfaces, where species-specific mutations often alter interaction specificity. This work presents a means to identify less-conserved DVs and provides insight into the relationship between evolutionarily coupled sites and human DVs.11Ysciescopu

An Empirical Study on L2 Accents of Cross-lingual Text-to-Speech Systems via Vowel Space

With the recent developments in cross-lingual Text-to-Speech (TTS) systems, L2 (second-language, or foreign) accent problems arise. Moreover, running a subjective evaluation for such cross-lingual TTS systems is troublesome. The vowel space analysis, which is often utilized to explore various aspects of language including L2 accents, is a great alternative analysis tool. In this study, we apply the vowel space analysis method to explore L2 accents of cross-lingual TTS systems. Through the vowel space analysis, we observe the three followings: a) a parallel architecture (Glow-TTS) is less L2-accented than an auto-regressive one (Tacotron); b) L2 accents are more dominant in non-shared vowels in a language pair; and c) L2 accents of cross-lingual TTS systems share some phenomena with those of human L2 learners. Our findings imply that it is necessary for TTS systems to handle each language pair differently, depending on their linguistic characteristics such as non-shared vowels. They also hint that we can further incorporate linguistics knowledge in developing cross-lingual TTS systems.Comment: Submitted to ICASSP 202

Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays

The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy

DEVELOPMENT OF A SMARTPHONE APPLICATION FOR ENVIRONMENTAL MONITORING

ABSTRACT This study is aimed to develop the monitoring application based on smartphone technology and assess its applicability in the remote monitoring research. For these purposes, we designed imaging instrument and a smartphone-based monitoring application. The proposed imaging instrument consisted of photovoltaic power generation part, power supply part, a smartphone and its body. This instrument had the advantages of its ability to supply power through photovoltaic power generation. The monitoring application automatically takes photographs in accordance with the monitoring schedule, and all monitoring information shall be sent to the web server. Using the data obtained from metric cameras and a terrestrial laser scanning, this study performed geometric correction and generated DEM, and the accuracy of the data obtained from the smartphone was assessed

Design space determination and process optimization of product quality attributes in transient rAAV manufacturing

Please click Additional Files below to see the full abstract