Pharmacist-led management of chronic pain in primary care:results from a randomised controlled exploratory trial

To compare the effectiveness of pharmacist medication review, with or without pharmacist prescribing, with standard care, for patients with chronic pain

Carrion - It's what's for dinner: Wolves reduce the impact of climate change.

Humans have viewed wolves as competitors, threats to personal safety, and symbols of evil throughout history. By the early part of the 20th century, grey wolves (Canis lupus) had been eradicated from 42% of their historic range in North America (Laliberte & Ripple, 2004). In Yellowstone National Park, grey wolves were hunted to local extinction by 1926, but were reintroduced in 1995 after a decades-long process involving biologists, politicians, ranchers and the general public. By the end of 2006, the wolf population in the park was at least 136 wolves in 13 packs (Smith et al., 2007). In this activity, high school students use mathematical models to explore how the presence of wolves buffers other carnivores and scavengers from the effects of climate change. By the end of the lesson, students should be able to: Define and give examples of keystone species, Demonstrate, using mathematical models, that ecosystems are more resilient to environmental change, when they contain a full complement of species, including top carnivores, Recognize that math is a vital tool in scientific investigations

Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis

A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as low as 500 ppm catalyst loadings. RCM of the five-membered carbamate series could be run neat, the six-membered carbamate series could be run at 1.0 M, and the seven-membered carbamate series worked best at 0.2−0.05 M

Summer Male Call Index Relative to Nesting Chronology and Autumn Density of the Northern Bobwhite

We studied breeding season male call counts and breeding behavior of the Northern Bobwhite (Colinus virginianus) to determine the relationship between male calling activity and nesting chronology. Additionally, we examined the relationship between breeding season call counts and fall population size. Standardized call count routes were conducted on 6 different sites located in southwest Georgia and north Florida during the breeding season months (1 Apr - 31 Sep) in 2001 and 2002. An information theoretic approach was used to evaluate a set of 7 candidate, linear-mixed models describing breeding season calling of bobwhite males. Of the candidate models, the model in which call counts depended on year and a quadratic effect of the number of incubating hens was the best approximating model, suggesting that the percentage of incubating hens had the greatest influence on activity of calling males. We also used multiple linear regression models to predict autumn northern bobwhite abundance from mean numbers of calling male bobwhites detected during the breeding season. Peaks in male calling activity occurring during June and July demonstrated a strong relationship (R2 = 0.987) with autumn population size, suggesting breeding season call counts were useful indices of autumn bobwhite abundance

A longitudinal study of muscle rehabilitation in the lower leg after cast removal using Magnetic Resonance Imaging and strength assessment

Acknowledgements We thank the A&E nurses and plaster technicians for identifying suitable patients, the MRI radiographers for performing the scanning, Dr Scott Semple for invaluable help in some of the pilot studies and Mr E. C. Stevenson for constructing the footrest used in the scanner. We are very grateful to the dedicated patients themselves who gave considerable amounts of time to come in for scanning, exercise and assessment during the course of this study.Peer reviewedPublisher PD

A Time to keep: history of the First United Methodist Church of Oviedo, Florida, 1873-1973.

Brief history of the church from its beginnings to 1973, including photographs of early members, changes in the church structure, the new church, and the first wedding performed in the new church. Also includes a list of pastors and other officers of the church.https://stars.library.ucf.edu/floridaheritage/1129/thumbnail.jp

How much do PCB toxic equivalents account for PHAH toxicity in predatory birds?

Various diffuse polyhalogenated aromatic hydrocarbons (PHAHs) exert common toxicity through the aryl hydrocarbon receptor (AhR). Apex predators spatially and temporally integrate diffuse contamination and simultaneous exposure can cause additive toxicity. We investigated the extent to which PCBs, still amongst the most prevalent PHAHs accumulated by predators, accounted for total PHAH toxicity in raptors and fish eating birds from Britain. We analysed egg or liver extracts from six species and compared chemically determined ΣPCB-TEQs concentrations with total AhR-mediated toxicity determined using the chemical-activated luciferase gene expression bioassay (CALUX-TEQ). Dioxin-like PCB profiles in eggs and livers were dominated by congeners 118, 105 and 167. ΣPCB-TEQ and CALUX-TEQ concentrations were positively associated but not in a 1:1 relationship. ΣPCB-TEQ were broadly similar to CALUX-TEQ concentrations in eggs and livers with CALUX-TEQ concentrations >50–80 and 160–320 pg g−1 lipid respectively, but were lower than CALUX-TEQ concentrations in less contaminated samples

Genome-wide association of familial late-onset alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late Onset Alzheimer's Disease Family Study and the National Cell Repository for Alzheimer's Disease conducted a joint genome-wide association study (GWAS) of multiplex LOAD families (3,839 affected and unaffected individuals from 992 families plus additional unrelated neurologically evaluated normal subjects) using the 610 IlluminaQuad panel. This cohort represents the largest family-based GWAS of LOAD to date, with analyses limited here to the European-American subjects. SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3.2×10-81), but no other genome-wide significant evidence for association was obtained in the full sample. Analyses that stratified on APOE genotypes identified SNPs on chromosome 10p14 in CUGBP2 with genome-wide significant evidence for association within APOE ε4 homozygotes (e.g., rs201119, p = 1.5×10-8). Association in this gene was replicated in an independent sample consisting of three cohorts. There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p = 0.009 with, and p = 0.03 without, APOE adjustment) and CLU (rs11136000, p = 0.023 with, and p = 0.008 without, APOE adjustment), with weaker support for CR1. However, our results provide strong evidence that association with PICALM (rs3851179, p = 0.69 with, and p = 0.039 without, APOE adjustment) and EXOC3L2 is affected by correlation with APOE, and thus may represent spurious association. Our results indicate that genetic structure coupled with ascertainment bias resulting from the strong APOE association affect genome-wide results and interpretation of some recently reported associations. We show that a locus such as APOE, with large effects and strong association with disease, can lead to samples that require appropriate adjustment for this locus to avoid both false positive and false negative evidence of association. We suggest that similar adjustments may also be needed for many other large multi-site studies. © 2011 Wijsman et al