Analysis of Eddy-Current Probe Signals in Steam Generator U-Bend Tubes Using the Finite Element Method

To ensure the integrity and safety of steam generator tubes in nuclear power plants, eddy-current testing is periodically employed. Because steam generators are equipped with thousands of thin-walled tubes, the eddy current is tested using a bobbin probe that can be used at high speed. Steam generator heat pipes in nuclear power plants have different sizes and shapes depending on their row number. In particular, heat pipes in the first row are located inside the steam generator and are of the U-bend type because the radius of the curved pipe is the smallest. A steam generator heat pipe has a thickness of about 1 mm, so a geometrical cross-sectional area change may occur due to residual stress when manufacturing the curved pipe. It is difficult to determine an exact shape because the change in cross-sectional area generated during the manufacturing process varies depending on the position of the pipe and the distortion rate. During eddy-current testing (ECT), to ensure the integrity and safety of the steam generator tubes, the shape change of the bend may cause a noise signal, making it difficult to evaluate defects in the pipe. However, the noise signals generated in this situation are difficult to analyze in a real measurement environment, and difficult to verify by producing a mock-up, which complicates distinguishing a noise signal from a defective signal. To solve this problem, various noise signals were obtained using the electromagnetic analysis method of COMSOL Multiphysics, a commercial program based on numerical analysis of the finite element method, to simulate the environment, including the change in cross-sectional area of the heat pipe. When compared to the actual measurement signal, the accuracy of the simulations improved, and various types of noise signals were detected, which may be helpful for accurate evaluations of defects during actual inspections

Analysis of Eddy-Current Probe Signals in Steam Generator U-Bend Tubes Using the Finite Element Method

To ensure the integrity and safety of steam generator tubes in nuclear power plants, eddy-current testing is periodically employed. Because steam generators are equipped with thousands of thin-walled tubes, the eddy current is tested using a bobbin probe that can be used at high speed. Steam generator heat pipes in nuclear power plants have different sizes and shapes depending on their row number. In particular, heat pipes in the first row are located inside the steam generator and are of the U-bend type because the radius of the curved pipe is the smallest. A steam generator heat pipe has a thickness of about 1 mm, so a geometrical cross-sectional area change may occur due to residual stress when manufacturing the curved pipe. It is difficult to determine an exact shape because the change in cross-sectional area generated during the manufacturing process varies depending on the position of the pipe and the distortion rate. During eddy-current testing (ECT), to ensure the integrity and safety of the steam generator tubes, the shape change of the bend may cause a noise signal, making it difficult to evaluate defects in the pipe. However, the noise signals generated in this situation are difficult to analyze in a real measurement environment, and difficult to verify by producing a mock-up, which complicates distinguishing a noise signal from a defective signal. To solve this problem, various noise signals were obtained using the electromagnetic analysis method of COMSOL Multiphysics, a commercial program based on numerical analysis of the finite element method, to simulate the environment, including the change in cross-sectional area of the heat pipe. When compared to the actual measurement signal, the accuracy of the simulations improved, and various types of noise signals were detected, which may be helpful for accurate evaluations of defects during actual inspections

CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells

Caffeic acid phenethyl ester (CAPE), a flavonoid-like compound, is one of the major components of honeybee propolis. In the present study, we investigated the metabolic effects of CAPE in skeletal muscle cells and found that CAPE stimulated glucose uptake in differentiated L6 rat myoblast cells and also activated AMPK (AMP-activated protein kinase). In addition, the inhibition of AMPK blocked CAPE-induced glucose uptake, and CAPE activated the Akt pathway in a PI3K (phosphoinositide 3-kinase)-dependent manner. Furthermore, CAPE enhanced both insulin-mediated Akt activation and glucose uptake. In summary, our results suggest that CAPE may have beneficial roles in glucose metabolism via stimulation of the AMPK pathway.close312

Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury

Yoo M, Khaled M, Gibbs KM, et al. Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury. Plos One. 2013;8(3): e57415.Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord injury. Application of the mammalian enzyme would be an attractive alternative to ChaseABC because of its more robust chemical stability and reduced immunogenicity. A one-time injection of human ARSB into injured mouse spinal cord eliminated immunoreactivity for chondroitin sulfates within five days, and up to 9 weeks after injury. After a moderate spinal cord injury, we observed improvements of locomotor recovery assessed by the Basso Mouse Scale (BMS) in ARSB treated mice, compared to the buffer-treated control group, at 6 weeks after injection. After a severe spinal cord injury, mice injected with equivalent units of ARSB or ChaseABC improved similarly and both groups achieved significantly more locomotor recovery than the buffer-treated control mice. Serotonin and tyrosine hydroxylase immunoreactive axons were more extensively present in mouse spinal cords treated with ARSB and ChaseABC, and the immunoreactive axons penetrated further beyond the injury site in ARSB or ChaseABC treated mice than in control mice. These results indicate that mammalian ARSB improves functional recovery after CNS injury. The structural/molecular mechanisms underlying the observed functional improvement remain to be elucidated