Entanglement generation in harmonic chains: tagging by squeezing

We address the problem of spring-like coupling between bosons in an open chain configuration where the counter-rotating terms are explicitly included. We show that fruitful insight can be gained by decomposing the time-evolution operator of this problem into a pattern of linear-optics elements. This allows us to provide a clear picture of the effects of the counter-rotating terms in the important problem of long-haul entanglement distribution. The analytic control over the variance matrix of the state of the bosonic register allows us to track the dynamics of the entanglement. This helps in designing a global addressing scheme, complemented by a proper initialization of the register, which quantitatively improves the entanglement between the extremal oscillators in the chain, thus providing a strategy for feasible long distance entanglement distribution.Comment: 8 pages, 8 figures, RevTeX

The N-Terminus of Apolipoprotein A-V Adopts a Helix-Bundle Molecular Architecture

Previous studies of recombinant full-length human apolipoprotein A-V (apoA-V) provided evidence of the presence of two independently folded structural domains. Computer-assisted sequence analysis and limited proteolysis studies identified an N-terminal fragment as a candidate for one of the domains. C-Terminal truncation variants in this size range, apoA-V(1-146) and apoA-V(1-169), were expressed in Escherichia coli and isolated. Unlike full-length apoA-V or apoA-V(1-169), apoA-V(1-146) was soluble in neutral-pH buffer in the absence of lipid. Sedimentation equilibrium analysis yielded a weight-average molecular weight of 18811, indicating apoA-V(1-146) exists as a monomer in solution. Guanidine HCl denaturation experiments at pH 3.0 yielded a one-step native to unfolded transition that corresponds directly with the more stable component of the two-stage denaturation profile exhibited by full-length apoA-V. On the other hand, denaturation experiments conducted at pH 7.0 revealed a less stable structure. In a manner similar to that of known helix bundle apolipoproteins, apoA-V(1-146) induced a relatively small enhancement in 8-anilino-1-naphthalenesulfonic acid fluorescence intensity. Quenching studies with single-Trp apoA-V(1-146) variants revealed that a unique site predicted to reside on the nonpolar face of an amphipathic R-helix was protected from quenching by KI. Taken together, the data suggest the 146 N-terminal residues of human apoA-V adopt a helix bundle molecular architecture in the absence of lipid and, thus, likely exist as an independently folded structural domain within the context of the intact protein

Suppressed dependence of polarization on epitaxial strain in highly polar ferroelectrics

A combined experimental and computational investigation of coupling between polarization and epitaxial strain in highly polar ferroelectric PbZr_0.2Ti_0.8O_3 (PZT) thin films is reported. A comparison of the properties of relaxed (tetragonality c/a = 1.05) and highly-strained (c/a = 1.09) epitaxial films shows that polarization, while being amongst the highest reported for PZT or PbTiO_3 in either film or bulk forms (P_r = 82 microC/cm^2), is almost independent of the epitaxial strain. We attribute this behavior to a suppressed sensitivity of the A-site cations to epitaxial strain in these Pb-based perovskites, where the ferroelectric displacements are already large, contrary to the case of less polar perovskites, such as BaTiO_3. In the latter case, the A-site cation (Ba) and equatorial oxygen displacements can lead to substantial polarization increases.Comment: 4 pages, 3 figure

A brief cognitive behavioural intervention for regular amphetamine users. A treatment guide.

A brief intervention using motivational and cognitive behavioural approaches to help change drug use. Also offer alternative brief interventions for clients not suited to the current approach. This manual is divided into five sections: Section 1. Context • Key points from the National Drug Strategy Monograph No 51. Models of Intervention and Care for Psychostimulant Users are included to present the evidence supporting this type of intervention for regular amphetamine users. • A flow-chart to place the intervention in a treatment context. Section 2. Brief background to the study and summary of results of evaluation • A brief description of how the study was developed, undertaken and evaluated. • A brief description of the evaluation outcome data (detailed results will be published separately). Section 3. The intervention • The CBT intervention is presented in a clear and easy to use format for practitioners. Section 4. Suggested alternative brief interventions for those not suitable for the current intervention • This section provides an overview of recommendations for alternative interventions for psychostimulant users who are unsuitable for the CBT intervention (e.g. those who are not considering change, experimental users etc). Section 5. Other available resources • This section lists a range of other resources that are currently available for practitioners working with psychostimulant users. This treatment guide has not been designed to stand alone. Rather, practitioners are encouraged to: 1. Acquaint themselves with the current research and clinical literature. The recently completed monograph Models of Intervention and Care for Psychostimulant Users is an excellent resource for current evidence supporting practice in this area. 2. Undertake training in CBT and motivational enhancement techniques if unfamiliar with these approaches. 3. Obtain ongoing clinical supervision

The effect of quantum memory on quantum games

We study quantum games with correlated noise through a generalized quantization scheme. We investigate the effects of memory on quantum games, such as Prisoner's Dilemma, Battle of the Sexes and Chicken, through three prototype quantum-correlated channels. It is shown that the quantum player enjoys an advantage over the classical player for all nine cases considered in this paper for the maximally entangled case. However, the quantum player can also outperform the classical player for subsequent cases that can be noted in the case of the Battle of the Sexes game. It can be seen that the Nash equilibria do not change for all the three games under the effect of memory.Comment: 26 pages, 7 ps figure

Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland

Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development. We demonstrate here that the developing mammary gland expresses high levels of inflammatory CC-chemokines, which are essential in vivo regulators of macrophage migration. We further demonstrate that the atypical chemokine receptor ACKR2, which scavenges inflammatory CC-chemokines, is differentially expressed during mammary gland development. We have previously shown that ACKR2 regulates macrophage dynamics during lymphatic vessel development. Here, we extend these observations to reveal a novel role for ACKR2 in regulating the postnatal development of the mammary gland. Specifically, we show that Ackr2−/− mice display precocious mammary gland development. This is associated with increased macrophage recruitment to the developing gland and increased density of the ductal epithelial network. These data demonstrate that ACKR2 is an important regulator of branching morphogenesis in diverse biological contexts and provide the first evidence of a role for chemokines and their receptors in postnatal development processes

Some Properties of Noether Charge and a Proposal for Dynamical Black Hole Entropy

We consider a general, classical theory of gravity with arbitrary matter fields in $n$ dimensions, arising from a diffeomorphism invariant Lagrangian, \bL. We first show that \bL always can be written in a ``manifestly covariant" form. We then show that the symplectic potential current $(n-1)$-form, $\th$, and the symplectic current $(n-1)$-form, \om, for the theory always can be globally defined in a covariant manner. Associated with any infinitesimal diffeomorphism is a Noether current $(n-1)$-form, \bJ, and corresponding Noether charge $(n-2)$-form, \bQ. We derive a general ``decomposition formula" for \bQ. Using this formula for the Noether charge, we prove that the first law of black hole mechanics holds for arbitrary perturbations of a stationary black hole. (For higher derivative theories, previous arguments had established this law only for stationary perturbations.) Finally, we propose a local, geometrical prescription for the entropy, $S_{dyn}$, of a dynamical black hole. This prescription agrees with the Noether charge formula for stationary black holes and their perturbations, and is independent of all ambiguities associated with the choices of \bL, $\th$, and \bQ. However, the issue of whether this dynamical entropy in general obeys a ``second law" of black hole mechanics remains open. In an appendix, we apply some of our results to theories with a nondynamical metric and also briefly develop the theory of stress-energy pseudotensors.Comment: 30 pages, LaTe

Black Hole Entropy is Noether Charge

We consider a general, classical theory of gravity in $n$ dimensions, arising from a diffeomorphism invariant Lagrangian. In any such theory, to each vector field, $\xi^a$, on spacetime one can associate a local symmetry and, hence, a Noether current $(n-1)$-form, ${\bf j}$, and (for solutions to the field equations) a Noether charge $(n-2)$-form, ${\bf Q}$. Assuming only that the theory admits stationary black hole solutions with a bifurcate Killing horizon, and that the canonical mass and angular momentum of solutions are well defined at infinity, we show that the first law of black hole mechanics always holds for perturbations to nearby stationary black hole solutions. The quantity playing the role of black hole entropy in this formula is simply $2 \pi$ times the integral over $\Sigma$ of the Noether charge $(n-2)$-form associated with the horizon Killing field, normalized so as to have unit surface gravity. Furthermore, we show that this black hole entropy always is given by a local geometrical expression on the horizon of the black hole. We thereby obtain a natural candidate for the entropy of a dynamical black hole in a general theory of gravity. Our results show that the validity of the ``second law" of black hole mechanics in dynamical evolution from an initially stationary black hole to a final stationary state is equivalent to the positivity of a total Noether flux, and thus may be intimately related to the positive energy properties of the theory. The relationship between the derivation of our formula for black hole entropy and the derivation via ``Euclidean methods" also is explained.Comment: 16 pages, EFI 93-4

Titration of Power Output During Radiofrequency Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75088/1/j.1540-8159.1993.tb01609.x.pd

On classical super-radiance in Kerr-Newman-anti-de Sitter black holes

We study in detail the modes of a classical scalar field on a Kerr-Newman-anti-de Sitter (KN-AdS) black hole. We construct sets of basis modes appropriate to the two possible boundary conditions (``reflective'' and ``transparent'') at time-like infinity, and consider whether super-radiance is possible. If we employ ``reflective'' boundary conditions, all modes are non-super-radiant. On the other hand, for ``transparent'' boundary conditions, the presence of super-radiance depends on our definition of positive frequency. For those KN-AdS black holes having a globally time-like Killing vector, the natural choice of positive frequency leads to no super-radiance. For other KN-AdS black holes, there is a choice of positive frequency which gives no super-radiance, but for other choices there will, in general, be super-radiance.Comment: 23 pages, 3 figures, v2: minor changes, references adde