??????????????? ????????? ????????? ?????? ??? ????????????

??????????????? ????????? ???????????? ???????????? ?????? ?????????????????? ??????????????? ?????? ???????????? ??????. ??? ??????????????? ??????????????? ??? ?????? ????????? ???????????? ????????? ??????????????? ????????? ???????????????. ?????? ??????????????? ????????? ??? ?????? ????????? ???????????????, ??? ?????? ????????? diethylnitrosamine (DEN)??? C3H/HeN ?????? ?????? ?????? ???????????? ??? ?????? ????????? ????????? ???????????????. DEN?????? ????????? ???????????? ?????? alkaline phosphatase (ALP) ??????, TUNEL positive ???????????? ??????, ??? ???????????? ?????? ???????????? duct??? ??????, ?????????????????? ????????????, Masson???s trichrome ???????????? ????????? ???????????? ???, ?????? ?????? ?????? ??? ????????? ????????? ???????????? ?????? ???????????? ?????? ?????? ????????? ??? ?????????. ?????????, ??????????????? ?????? ???????????? ????????? ?????? ?????????????????? ??????, ?????? ?????? ??? ????????? ???????????? ??????????????? ???????????? ???????????? ???????????? ?????? ?????? ????????? ??? ?????????. ???????????? ???????????? ????????? ???????????? ??????, ???????????? ???????????? ???????????? ?????? ????????? ???, solvent partition ????????? ???????????? ????????? ???????????? hexane, ethyl acetate, water ???????????? ???????????????. ?????? ??????????????? ?????? ????????? ??????????????? ??????????????? ???, ethyl acetate ???????????? ??????????????? ????????? ?????????????????? ??????????????? ?????? ??????????????? ???????????? ????????? ????????? ????????? ??? ?????????. ????????? ethyl acetate???????????? ???????????? ????????? ????????? ??? ?????????, ??????????????? ????????? ??? ?????? ????????? ????????? ?????????. ???????????????, ??????????????? ????????? ????????????????????? ?????? ????????? ??? ?????? ????????? ???????????? ?????? ??????????????? ????????? ??? ?????? ????????? ????????? ????????? ?????? ???????????????. ?????????, ?????? ??????????????? ?????? ???????????? ?????? ??? ?????? ?????? ???????????? ??????????????? ?????? ????????? ????????? ??? ?????? ????????? ???????????? ??????.clos

Anti-Obesity Effects of Morus alba L. and Aronia melanocarpa in a High-Fat Diet-Induced Obese C57BL/6J Mouse Model

The present study investigated the synergic effect of extracts of Morus alba (MA) and Aronia melanocarpa (Michx.) (AR) against high-fat diet induced obesity. Four-week-old male C57BL/6J mice were randomly divided into five groups that were fed for 14 weeks with a normal diet (ND), high-fat diet (HD), HD with M. alba 400 mg/kg body weight (MA), HD with A. melanocarpa 400 mg/kg body weight (AR), or HD with a mixture (1:1, v/v) of M. alba and A. melanocarpa (400 mg/kg) (MA + AR). Treatment with MA, AR, and MA + AR for 14 weeks reduced high fat diet-induced weight gain and improved serum lipid levels, and histological analysis revealed that MA and AR treatment markedly decreased lipid accumulation in the liver and adipocyte size in epididymal fat. Furthermore, micro-CT images showed MA + AR significantly reduced abdominal fat volume. Expression levels of genes involved in lipid anabolism, such as SREBP-1c, PPAR-gamma, CEBP alpha, FAS, and CD36 were decreased by MA + AR treatment whereas PPAR-alpha, ACOX1, and CPT-1a levels were increased by MA + AR treatment. Protein expression of p-AMPK and p-ACC were increased in the MA + AR group, indicating that MA + AR ameliorated obesity by upregulating AMPK signaling. Together, our findings indicate that MA and AR exert a synergistic effect against diet-induced obesity and are promising agents for managing obesity

A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model

Abstract Aerobic exercise is well known to have a positive impact on body composition, muscle strength, and oxidative capacity. In animal model, both treadmill and wheel running exercise modalities have become more popular, in order to study physiological adaptation associated with aerobic exercise. However, few studies have compared physiological adaptations in response to either treadmill exercise (TE), or voluntary wheel running exercise (WE). We therefore compared each exercise intervention on body composition and oxidative markers in male C57BL/6 N mice. The total distance run was remarkably higher in the WE group than in the TE group. Both forms of exercise resulted in the reduction of body weight, fat mass, and adipocyte size. However, the average for grip strength of WE was higher than for control and TE. Interestingly, PGC-1α expression was increased in the gastrocnemius (glycolytic-oxidative) and soleus (oxidative) muscle of TE group, whereas WE showed a significant effect on PGC-1α expression only in the soleus muscle. However, muscle fiber type composition was not shifted remarkably in either type of exercise. These results suggest that TE and WE may exert beneficial effects in suppressing metabolic risks in mouse model through attenuating body weight, fat mass, size, and increase in mitochondria biogenesis marker, PGC-1α

Improvements in pulp properties by alkali preextraction and subsequent kraft pulping with controlling H-factor and alkali charge

The objective of this study was to determine the processing conditions for obtaining improved pulp properties from the kraft pulping process with an alkali pre-extraction stage. Before the kraft pulping, a pre-extraction of hemicelluloses from mixed hardwood chips was performed with two different alkali concentrations (3% and 12% as Na2O) at 150 °C for 90 minutes. The kraft pulping of the pre-extracted chips was then conducted in two ways: with either the H-factor alone controlled or with both the H-factor and the alkali charge controlled. When the chips were pre-extracted with the 3% alkali charge and with the kraft pulping controlled to an H-factor of 500, the yield and properties of the pulp were higher than those of the reference kraft pulp. The 12% alkali pre-extraction and kraft pulping resulted in a low yield of screened pulp. However, when the alkali charge and the H-factor were adjusted together, the pulp yield remained constant and the pulp properties improved in comparison to the reference pulp for both the 3 and 12% cases

A Case of More Abundant and Dysplastic Adenomas in the Interposed Colon than in the Native Colon

We report a 60-year-old woman with intramucosal adenocarcinoma arising in the interposed colon, 40 years after the esophageal reconstruction for lye induced esophageal stricture. Although synchronous adenomas were also found in the native colon where the graft was taken, the number of adenomas was greater in the interposed colon and more dysplastic, even progressed to adenocarcinoma, than that of the native colon. The microsatellite instability-testing performed in the intramucosal carcinoma from interposed colon showed absence of microsatellite instability. Changing of location and functional deman]d of colonic segment, and the exposure to different intraluminal contents might have facilitated the adenomacarcinoma transformation in the interposed colon