Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior.

The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input from the secondary motor cortex (M2), an area involved in licking, and the parafascicular thalamic nucleus (PF). Using neural recordings, together with optogenetic terminal inhibition, we examine the contribution of M2 and PF projections on medium spiny projection neuron (MSN) activity as mice performed an anticipatory licking task. Each input has a similar contribution to striatal activity. By comparing how suppressing single or multiple projections altered striatal activity, we find that cortical and thalamic input signals modulate MSN gain and that this effect is more pronounced in a temporally specific period of the task following the cue presentation. These results demonstrate that cortical and thalamic inputs synergistically regulate striatal output during reward-conditioned behavior

Entangled Design Knowledge: Relationships as an Approach to Claims Reuse

As a discipline, human-computer interaction produces creative and innovative designs that could provide a reusable collection of design knowledge on which future efforts could build. It is unfortunate that so much of this knowledge is not fully reused by designers today. To encourage the use of previously identified HCI knowledge, we propose a model of reuse building on Carroll?s notion of claims, design knowledge components that capture the positive and negative psychological effects of design features. We address four challenges associated with reuse in a library of claims, adopted from software engineering?a discipline in which the notion of reuse has been prevalent for quite some time. Building on Krueger?s definition of reuse and his conceptualization of four key aspects?abstraction, selection, specification, and integration?we propose a reuse approach based on incorporating these four aspects into the design process. To abstract, select, specify and integrate claims, we identify claim relationships, descriptions of connections between claims. We portray how claim relationships can be used to aid in identifying claim types, searching for claims, creating new claims, and aggregating claims. By integrating relationships into a claims library, we demonstrate how they can be applied to assist claims reuse and present studies related to each application of the relationships

Alternative new notation for quantum information theory

A new notation has been introduced for the quantum information theory. By this notation,some calculations became simple in quantum information theory such as quantum swapping, quantum teleportation.Comment: submitte

Innovation in Malaysia wood based manufacturing firm: An illuminating case study

The purpose of this paper is to highlight the innovation pattern and strategy in wood-based upstream production in view of its significance in the LMT (Low and Medium Technology) industries in a developing economy such as Malaysia.The design of this research is based on a single case study approach.Purposive sampling technique was used and data collection obtained through interview approach.Semi-structured interview was conducted with the general manager of one of the selected wood based manufacturing firm in the state of Selangor, Malaysia which fulfilled the basic criterion set chosen such as the experience involved in innovative activities in past three years.The major findings of the study implied that both product and process innovation are complementary to each other.Sequentially, product innovation takes place and followed by the process innovation.In addition, it has been observed that both competition and market demand induces innovation activities in the wood-based innovation in the manufacturing firm.It is also detected that virtually customers have actively involved in the firm’s innovation process.Alternatively, trade shows, exhibition, online furniture deco webpage, and Wood Furniture Association are traced as the important external sources which have contributed to the information in the firm’s innovation process.Information gathered from the external sources subsequently transformed into internal innovation through trial and error process by internal employees of the firm

Density-functional calculation of ionization energies of current-carrying atomic states

Current-density-functional theory is used to calculate ionization energies of current-carrying atomic states. A perturbative approximation to full current-density-functional theory is implemented for the first time, and found to be numerically feasible. Different parametrizations for the current-dependence of the density functional are critically compared. Orbital currents in open-shell atoms turn out to produce a small shift in the ionization energies. We find that modern density functionals have reached an accuracy at which small current-related terms appearing in open-shell configurations are not negligible anymore compared to the remaining difference to experiment.Comment: 7 pages, 2 tables, accepted by Phys. Rev.

Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice

We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes. The db/db mice were randomly assigned to high-carbohydrate diets (66.1% corn starch) with and without AF (4% in the diet) for 6 weeks. Changes in body weight, blood glucose level, and food intake were measured daily for 42 days. Dietary supplementation of AF resulted in a significant decrease of blood glucose level (p \u3c 0.001) and body weight (p \u3c 0.001). The level of HbA1c, a better indicator of plasma glucose concentration over prolonged periods of time, was also significantly decreased for 6-week period (p \u3c 0.001). Dietary treatment of acarbose® (0.04% in diet), a positive control, also significantly alleviated the level of blood glucose, HbA1c, and body weight. These results indicate that AF Maillard reaction product improves postprandial hyperglycemia by suppressing glucose absorption as well as decreasing HbA1c level

Strain distribution analysis of sputter-formed strained Si by tip-enhanced Raman spectroscopy

Simultaneous nanometer-scale measurements of the strain and surface undulation distributions of strained Si (s-Si) layers on strain-relief quadruple-Si1-xGex-layer buffers, using a combined atomic force microscopy (AFM) and tip-enhanced Raman spectroscopy (TERS) system, clarify that an s-Si sample formed by our previously proposed sputter epitaxy method has a smoother and more uniformly strained surface than an s-Si sample formed by gas-source molecular beam epitaxy. The TERS analyses suggest that the compositional fluctuation of the underlying Si1-xGex buffer layer is largely related to the weak s-Si strain fluctuation of the sputtered sampl

Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns

Flow fractionation of cells using physical fields to achieve lateral displacement finds wide applications, but its extension to surface molecule-specific separation requires labeling. Here we demonstrate affinity flow fractionation (AFF) where weak, short-range interactions with asymmetric molecular patterns laterally displace cells in a continuous, label-free process. We show that AFF can directly draw neutrophils out of a continuously flowing stream of blood with an unprecedented 400,000-fold depletion of red blood cells, with the sorted cells being highly viable, unactivated, and functionally intact. The lack of background erythrocytes enabled the use of AFF for direct enumeration of neutrophils by a downstream detector, which could distinguish the activation state of neutrophils in blood. The compatibility of AFF with capillary microfluidics and its ability to directly separate cells with high purity and minimal sample preparation will facilitate the design of simple and portable devices for point-of-care diagnostics and quick, cost-effective laboratory analysis