A new framework to assess relative ecosystem vulnerability to climate change

Climate change poses a growing risk to global biodiversity. To prioritize conservation efforts, identification of the species and ecosystems most at risk from further changes in climatic conditions is critically needed. Although frameworks are available to assess species vulnerability to climate change, we still lack an easily implementable, ecosystem‐level perspective to inform landscape management. Here, we introduce a novel, spatially explicit vulnerability framework able to generate assessments at the ecosystem scale and apply it to Mozambican forest mangroves, which are under growing pressures from climate change. Results show that most of these ecosystems are currently highly vulnerable to sea level rise, while mangroves in the Zambezia and Nampula districts are highly vulnerable to both sea level rise and tropical storms. Altogether, we believe the introduced assessment framework has clear potential to inform conservation planning and management at various spatial scales, and help achieve adaptive management in the face of climatic uncertainties

Predicting conservation priority areas in Borneo for the critically endangered helmeted hornbill (Rhinoplax vigil)

The critically endangered helmeted hornbill (Rhinoplax vigil) is under threat around its Southeast Asian range due to hunting and habitat loss. Dependant on primary rainforest habitats, the species is thought to be highly sensitive to habitat disturbance. Compounding this is the threat of climate change where equatorial ecosystems, such as those found on Borneo, are predicted to increase in temperature and precipitation. It is therefore important to identify whether the species’ suitable habitats, both now and in the future, are protected from further anthropogenic disturbance. In this study we used species distribution models to assess the extent of suitable habitat for R. vigil across Borneo, an island which has undergone rapid deforestation in recent years, and a stronghold for the species. Using 302 R. vigil occurrence records, four environmental and three land-use cover variables, we modelled R. vigil current habitat suitability, and two future projections under climate change scenarios RCP 4.5 and RCP 8.5 for 2041–2060. Our results suggest that a quarter of Borneo's landmass is currently suitable for R. vigil. However, there is a steep decline in the predicted suitable habitat from 335,963 km2 (current scenario) to 73,170 km2 (future RCP 4.5), to 54,839 km2 (future RCP 8.5). Our model predicts that the amount of suitable habitat protected by current protected areas (PAs) and the planned Heart of Borneo (HoB) initiative will increase under future climate change, with the HoB protecting > 65 % of R. vigil suitable habitat across all projections. This is likely worsened by future land-use change not included in these models, which is a limitation to our study. We therefore encourage the connectivity of lowland PAs, and the continuation of HoB targets to prevent further decline of R. vigil habitat around Borneo. This study provides the first species-specific spatial assessment of the critically endangered helmeted hornbill distribution in response to climate change across current and planned protected regions in Borneo

Code_for_Eucalyptus

This file includes code for extracting the locations of eucalyptus trees using MODIS NPP in Google Earth Engine, as well as code for machine learning modeling and prediction in R.</p

Software_availability_of_ecological_niche_model

This document includes software and data availability of ecological niche model.</p

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field