Scalar Non-Luminous Matter in Galaxies

As a candidate for dark matter in galaxies, we study an SU(3) triplet of complex scalar fields which are non-minimally coupled to gravity. In the spherically symmetric static spacetime where the flat rotational velocity curves of stars in galaxies can be explained, we find simple solutions of scalar fields with SU(3) global symmetry broken to U(1) X U(1), in an exponential scalar potential, which will be useful in a quintessence model of the late-time acceleration of the Universe.Comment: 6 pages, no figure, LaTex. Submitted to IJMP

Hidden Local Symmetry and Infinite Tower of Vector Mesons for Baryons

In an effort to access dense baryonic matter relevant for compact stars in a unified framework that handles both single baryon and multibaryon systems on the same footing, we first address a holographic dual action for a single baryon focusing on the role of the infinite tower of vector mesons deconstructed from five dimensions. To leading order in 't Hooft coupling $\lambda=N_c g_{\rm YM}^2$, one has the Bogomol'nyi-Prasad-Sommerfield (BPS) Skyrmion that results when the warping of the bulk background and the Chern-Simons term in the Sakai-Sugimoto D4/D8-${\bar{\rm D8}}$ model are ignored. The infinite tower was found by Sutcliffe to induce flow to a conformal theory, i.e., the BPS. We compare this structure to that of the SS model consisting of a 5D Yang-Mills action in warped space and the Chern-Simons term in which higher vector mesons are integrated out while preserving hidden local symmetry and valid to $O(\lambda^0)$ and $O(p^4)$ in the chiral counting. We point out the surprisingly important role of the $\omega$ meson that figures in the Chern-Simons term that encodes chiral anomaly in the baryon structure and that may be closely tied to short-range repulsion in nuclear interactions.Comment: 9 pages, REVTeX, to be published in Phys. Rev.

Observation of First-Order Metal-Insulator Transition without Structural Phase Transition in VO_2

An abrupt first-order metal-insulator transition (MIT) without structural phase transition is first observed by current-voltage measurements and micro-Raman scattering experiments, when a DC electric field is applied to a Mott insulator VO_2 based two-terminal device. An abrupt current jump is measured at a critical electric field. The Raman-shift frequency and the bandwidth of the most predominant Raman-active A_g mode, excited by the electric field, do not change through the abrupt MIT, while, they, excited by temperature, pronouncedly soften and damp (structural MIT), respectively. This structural MIT is found to occur secondarily.Comment: 4 pages, 4 figure

Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus-mediated gene transfer

Introduction Sjögren's syndrome (SS) involves a chronic, progressive inflammation primarily of the salivary and lacrimal glands leading to decreased levels of saliva and tears resulting in dry mouth and dry eye diseases. Seminal findings regarding TH17 cell populations that secrete predominantly interleukin (IL)-17A have been shown to play an important role in an increasing number of autoimmune diseases, including SS. In the present study, we investigated the function of IL-17A on the development and onset of SS. Methods Adenovirus serotype 5 (Ad5) vectors expressing either IL-17A or LacZ were infused via retrograde cannulation into the salivary glands of C57BL/6J mice between 6 and 8 weeks of age or between 15 and 17 weeks of age. The mice were characterized for SS phenotypes. Results Disease profiling indicated that SS-non-susceptible C57BL/6J mice whose salivary glands received the Ad5-IL17A vector developed a SS-like disease profile, including the appearance of lymphocytic foci, increased cytokine levels, changes in antinuclear antibody profiles, and temporal loss of saliva flow. Conclusions Induction of SS pathology by IL-17A in SS-non-susceptible mice strongly suggests that IL-17A is an important inflammatory cytokine in salivary gland dysfunction. Thus, localized anti-IL17 therapy may be effective in preventing glandular dysfunction.National Institute of Dental and Craniofacial Research (U.S.) (PHS Grants K99DE018958)National Institute of Allergy and Infectious Diseases (U.S.) (R21AI081952)Sjogren's Syndrome FoundationUniversity of Florida. Center for Orphaned Autoimmune DisordersNational Institute of Dental and Craniofacial Research (U.S.) (Intramural research grant)National Institutes of Health (U.S.

ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice

Normal leptin signaling is essential for the maintenance of body weight homeostasis. Proopiomelanocortin- and agouti-related peptide (AgRP)-producing neurons play critical roles in regulating energy metabolism. Our recent work demonstrates that deletion of Rho-kinase 1 (ROCK1) in the AgRP neurons of mice increased body weight and adiposity. Here, we report that selective loss of ROCK1 in AgRP neurons caused a significant decrease in energy expenditure and locomotor activity of mice. These effects were independent of any change in food intake. Furthermore, AgRP neuron-specific ROCK1-deficient mice displayed central leptin resistance, as evidenced by impaired Signal Transducer and Activator of Transcription 3 activation in response to leptin administration. Leptin's ability to hyperpolarize and decrease firing rate of AgRP neurons was also abolished in the absence of ROCK1. Moreover, diet-induced and genetic forms of obesity resulted in reduced ROCK1 activity in murine arcuate nucleus. Of note, high-fat diet also impaired leptin-stimulated ROCK1 activity in arcuate nucleus, suggesting that a defect in hypothalamic ROCK1 activity may contribute to the pathogenesis of central leptin resistance in obesity. Together, these data demonstrate that ROCK1 activation in hypothalamic AgRP neurons is required for the homeostatic regulation of energy expenditure and adiposity. These results further support previous work identifying ROCK1 as a key regulator of energy balance and suggest that targeting ROCK1 in the hypothalamus may lead to development of antiobesity therapeutics.publishersversionpublishe

Large Linear Magnetoresistance in Heavily-Doped Nb:SrTiO\u3csub\u3e3\u3c/sub\u3e Epitaxial Thin Films

Interaction between electrons has long been a focused topic in condensed-matter physics since it has led to the discoveries of astonishing phenomena, for example, high-Tc superconductivity and colossal magnetoresistance (CMR) in strongly-correlated materials. In the study of strongly-correlated perovskite oxides, Nb-doped SrTiO3 (Nb:SrTiO3) has been a workhorse not only as a conducting substrate, but also as a host possessing high carrier mobility. In this work, we report the observations of large linear magnetoresistance (LMR) and the metal-to-insulator transition (MIT) induced by magnetic field in heavily-doped Nb:STO (SrNb0.2Ti0.8O3) epitaxial thin films. These phenomena are associated with the interplay between the large classical MR due to high carrier mobility and the electronic localization effect due to strong spin-orbit coupling, implying that heavily Nb-doped Sr(Nb0.2Ti0.8)O3 is promising for the application in spintronic devices

Energy levels of the soliton--heavy-meson bound states

We investigate the bound states of heavy mesons with finite masses to a classical soliton solution in the Skyrme model. For a given model Lagrangian we solve the equations of motion exactly so that the heavy vector mesons are treated on the same footing as the heavy pseudoscalar mesons. All the energy levels of higher grand spin states as well as the ground state are given over a wide range of the heavy meson masses. We also examine the validity of the approximations used in the literatures. The recoil effect of finite mass soliton is naively estimated.Comment: 24 pages, REVTeX v3.0, 6 figures are available upon request