Eco-innovative Method to Improve the Distribution Phase of Product

The integration of the environmental dimension is crucial in industrial activity. Designers should integrate the new environmental constraints to adapt their approaches and methodologies in the framework of eco-innovation of industrial products and consumer goods. This paper proposes a new method integrating ecological aspects into the innovation process composed of three main stages: an analysis and structuring of the product, the formalization of the problem and the resolution phase. According to the structuring and the design objectives, actions can be selected and allow to guide the design to the most relevant modification to perform on the product. An illustration of the approach is applied on the optimization of the environmental impacts related to the logistical aspects

Towards QoS-Oriented SLA Guarantees for Online Cloud Services

International audienceCloud Computing provides a convenient means of remote on-demand and pay-per-use access to computing resources. However, its ad hoc management of quality-of-service and SLA poses significant challenges to the performance, dependability and costs of online cloud services. The paper precisely addresses this issue and makes a threefold contribution. First, it introduces a new cloud model, the SLAaaS (SLA aware Service) model. SLAaaS enables a systematic integration of QoS levels and SLA into the cloud. It is orthogonal to other cloud models such as SaaS or PaaS, and may apply to any of them. Second, the paper introduces CSLA, a novel language to describe QoS-oriented SLA associated with cloud services. Third, the paper presents a control-theoretic approach to provide performance, dependability and cost guarantees for online cloud services, with time-varying workloads. The proposed approach is validated through case studies and extensive experiments with online services hosted in clouds such as Amazon EC2. The case studies illustrate SLA guarantees for various services such as a MapReduce service, a cluster-based multi-tier e-commerce service, and a low-level locking service

Genetic survey of shallow populations of the Mediterranean red coral [ Corallium rubrum (Linnaeus, 1758)]: new insights into evolutionary processes shaping nuclear diversity and implications for conservation

International audienceCombined action from over-harvesting and recent mass mortality events potentially linked to ongoing climate changes has led to new concerns for the conservation of shallow populations (5-60 m) of Corallium rubrum, an octocorallian that is mainly found in the Mediterranean Sea. The present study was designed to analyse population structure and relationships at different spatial scales (from 10s of meters to 100s of kilometres) with a focus on dispersal pattern. We also performed the first analysis of the distribution of genetic diversity using a comparative approach between regional-clusters and samples. Forty populations dwelling in four distinct regions between 14 and 60 m in depth were genotyped using 10 microsatellites. Our main results indicate (i) a generalized pair-sample differentiation combined with a weak structure between regional-clusters; (ii) the occurrence of isolation by distance at the global scale, but also within two of the three analysed regional-clusters; (iii) a high level of genetic diversity over the surveyed area with a heterogeneous distribution from regional-cluster to sample levels. The evolutionary consequences of these results are discussed and their management implications are provided

Combination therapy versus monotherapy: a randomised pilot study on the evolution of inflammatory parameters after ventilator associated pneumonia [ISRCTN31976779]

INTRODUCTION: Combination antibiotic therapy for ventilator associated pneumonia (VAP) is often used to broaden the spectrum of activity of empirical treatment. The relevance of such synergy is commonly supposed but poorly supported. The aim of the present study was to compare the clinical outcome and the course of biological variables in patients treated for a VAP, using a monotherapy with a beta-lactam versus a combination therapy. METHODS: Patients with VAP were prospectively randomised to receive either cefepime alone or cefepime in association with amikacin or levofloxacin. Clinical and inflammatory parameters were measured on the day of inclusion and thereafter. RESULTS: Seventy-four mechanically ventilated patients meeting clinical criteria for VAP were enrolled in the study. VAP was microbiologically confirmed in 59 patients (84%). Patients were randomised to receive cefepime (C group, 20 patients), cefepime with amikacin (C-A group, 19 patients) or cefepime with levofloxacin (C-L group, 20 patients). No significant difference was observed regarding the time course of temperature, leukocytosis or C-reactive protein level. There were no differences between length of stay in the intensive care unit after infection, nor in ventilator free days within 28 days after infection. No difference in mortality was observed. CONCLUSION: Antibiotic combination using a fourth generation cephalosporin with either an aminoside or a fluoroquinolone is not associated with a clinical or biological benefit when compared to cephalosporin monotherapy against common susceptible pathogens causing VAP

Parsimonious analysis for eco-innovation of products

The integration of the environmental dimension is crucial in industrial activity. Designers should integrate the new environmental constraints to adapt their approaches and methodologies in the framework of eco-innovation of industrial products and consumer goods. This paper proposes a new method integrating ecological aspects into the innovation process. We analyze different tools proposed in the literature to determine the relevant parameters to consider for assuring an efficient methodology. Relevant parameters are related to different phases in the lifecycle of the product and it is proposed to link them to different impacts on the environment. Actions are set up to guide engineers in the early phase of concept generation for eco-innovation. The methodology is essentially based on functional analysis, energy analysis and physical analysis of products and problem solving tools stemming from Triz theory

Using Gravitational Lensing to study HI clouds at high redshift

We investigate the possibility of detecting HI emission from gravitationally lensed HI clouds (akin to damped Lyman-$\alpha$ clouds) at high redshift by carrying out deep radio observations in the fields of known cluster lenses. Such observations will be possible with present radio telescopes only if the lens substantially magnifies the flux of the HI emission. While at present this holds the only possibility of detecting the HI emission from such clouds, it has the disadvantage of being restricted to clouds that lie very close to the caustics of the lens. We find that observations at a detection threshold of 50 micro Jy at 320 MHz (possible with the GMRT) have a greater than 20% probability of detecting an HI cloud in the field of a cluster, provided the clouds have HI masses in the range 5 X 10^8 M_{\odot} < M_{HI} < 2.5 X 10^{10} M_{\odot}. The probability of detecting a cloud increases if they have larger HI masses, except in the cases where the number of HI clouds in the cluster field becomes very small. The probability of a detection at 610 MHz and 233 MHz is comparable to that at 320 MHz, though a definitive statement is difficult owing to uncertainties in the HI content at the redshifts corresponding to these frequencies. Observations at a detection threshold of 2 micro Jy (possible in the future with the SKA) are expected to detect a few HI clouds in the field of every cluster provided the clouds have HI masses in the range 2 X 10^7 M_{\odot} < M_{HI} < 10^9 M_{\odot}. Even if such observations do not result in the detection of HI clouds, they will be able to put useful constraints on the HI content of the clouds.Comment: 21 pages, 7 figures, minor changes in figures, accepted for publication in Ap