A SMART decade: outcomes of an integrated, inclusive, first-year college-level STEM curricular innovation

In the early 2000s, our primarily undergraduate, white institution (PUI/PWI), began recruiting and enrolling higher numbers of students of color and first-generation college students. However, like many of our peer institutions, our established pedagogies and mindsets did not provide these students an educational experience to enable them to persist and thrive in STEM. Realizing the need to systematically address our lack of inclusivity in science majors, in 2012 faculty from multiple disciplines developed the Science, Math, and Research Training (SMART) program. Here, we describe an educational innovation, originally funded by a grant from the Howard Hughes Medical Institute, designed to support and retain students of color, first generation college students, and other students with marginalized identities in the sciences through a cohort-based, integrated, and inclusive first-year experience focused on community and sense of belonging. The SMART program engages first-year students with semester-long themed courses around “real world” problems of antibiotic resistance and viral infections while integrating the fields of Biology, Chemistry, Mathematics, and an optional Computer Science component. In the decade since its inception, 97% of SMART students have graduated or are on track to graduate, with 80.9% of these students earning a major in a STEM discipline. Here, we present additional student outcomes since the initiation of this program, results of the student self-evaluative surveys SALG and CURE, and lessons we have learned from a decade of this educational experience

Developing a Generalizable Approach to Improve the Blood Brain Barrier Permeability of Proteolysis Targeting Chimeras through Prodrugs

Proteolysis targeting chimeras (PROTACs) are a promising class of molecular probes that can elicit degradation of classically undruggable targets. This capability comes with a large size (>1000Da), and thus reduced cell permeability: this extends to the blood brain barrier (BBB), effectively limiting the employment of PROTACs as in vivo probes for pharmacologically relevant targets that lie in the central nervous system. Strategies for small molecule inhibitors generally cannot be applied to PROTACs due to their large size, however one such approach that shows promise is the prodrug approach, in which a labile attachment known as a promoiety is attached to a pharmacologically active site of a drug with the purpose of improving physicochemical properties. To date, no studies exist which utilize the prodrug approach as a means of improving the BBB permeability of PROTACs. The work herein describes our efforts to develop a generalizable strategy to improve the BBB permeability of PROTACs through the prodrug approach, as to expand the degradable proteome into the CNS

Présentation

Vigarello Georges, Leconte Bernard. Présentation. In: Communications, 67, 1998. Le spectacle du sport, sous la direction de Bernard Leconte et Georges Vigarello. pp. 5-7

Présentation

Vigarello Georges, Leconte Bernard. Présentation. In: Communications, 67, 1998. Le spectacle du sport, sous la direction de Bernard Leconte et Georges Vigarello. pp. 5-7

Targeted Protein Degradation: Design Considerations for PROTAC Development

Targeted protein degradation has recently gained widespread interest as both a novel therapeutic strategy and a useful tool in biomedical research. Targeted protein degraders are often sub-stoichiometric and do not require strong binding affinity for their targets, enabling access to previously inaccessible targets. Proteolysis-targeting chimeras (PROTACs) are one class of targeted protein degraders that promote degradation by recruiting a target protein to an E3-ligase complex via a heterobifunctional molecule. The modular nature of PROTACs allows for their rational design and systematic optimization. Here we suggest resources and methodologies for developing PROTAC degraders for researchers that may be new to the field. © 2022 Wiley Periodicals LLC

Tunable dual-wavelength laser in the 2 μm region, based on a polarization-maintaining large mode area thulium-doped fiber

International audienc

Surveillance Ecologique du site du "Blayais" - Année 1998

Monotoring n° 21 of the BLAYAIS nuclear power plant takes into account studies conducted between March and November 1998. Physicochemistry, Hydrobiology, Bacteriology, Zooplankton, Bathymetry, are reported.L'étude de surveillance n° 21 du site électronucléaire du BLAYAIS (département de la Gironde) concerne la période de mars à novembre 1998. Le domaine pélagique est étudié (physico-chimie, hydrobiologie, bactériologie, zooplancton, bathymétrie)

Widely tunable dual-wavelength fiber laser in the 2 μm wavelength range

International audienc

Surveillance écologique du site du Blayais. Année 1999

Monitoring n°22 of the BLAYAIS nuclear power plant takes into account studies conducted between April and November 1996. Physicochemistry, Hydrobiology, Bacteriology, Zooplankton, Bathymetry, are reported. [see summary p. 251-252 (in french)]L'etude de surveillance n°22 du site electronucleaire du BLAYAIS (departement de la Gironde) conceme la periode d' avril a novembre 1996. le domaine pelagique est etudie (physico chimie, hydrobiologie, bacteriologie, zooplancton, bathymetrie). [Voir fiche resume p. 251-252