Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Bargaining, Nuclear Proliferation, and Interstate Disputes

Contrasting claims about the consequences of nuclear weapons rely on different interpretations about how leaders respond to risk, uncertainty, and the balance of power. Nuclear optimists use deterrence theory to argue that proliferation can promote stability and inhibit the use of force. Pessimists argue that proliferation precipitates nuclear hubris, accident, or anger that heightens the risk of war. It is also possible that nuclear weapons have no net effect on dispute propensity. Since states fashion their own bargains, nuclear status is bound to influence the distribution of influence. Proliferation also reflects existing tensions, biasing upward the apparent impact of nuclear weapons on conventional conflict. Instrumenting for the decision to proliferate, the authors find that nuclear weapons increase diplomatic status without much affecting whether states fight