Islamism and Security in Bosnia-Herzegovina

View the Executive SummaryU.S. experts fear violence could once again break out in Bosnia-Herzegovina, and some even want the North Atlantic Treaty Organization (NATO) to mount another military mission there. Yet few of these experts focus on the danger of gradually expanding Islamism. In Bosnia, it appears to have made slow but steady progress, despite resistance from Bosnia’s moderate Muslims. Senior Bosniak (Muslim) leaders retain their long-standing Islamist ties, and their calls to impose traditional Islamic law, or sharia, and develop closer ties with the Islamic world only aggravate Bosnian Croat and Serb separatism.https://press.armywarcollege.edu/monographs/1496/thumbnail.jp

Chemical genetics strategies for identification of molecular targets

Chemical genetics is an emerging field that can be used to study the interactions of chemical compounds, including natural products, with proteins. Usually, the identification of molecular targets is the starting point for studying a drug’s mechanism of action and this has been a crucial step in understanding many biological processes. While a great variety of target identification methods have been developed over the last several years, there are still many bioactive compounds whose target proteins have not yet been revealed because no routine protocols can be adopted. This review contains information concerning the most relevant principles of chemical genetics with special emphasis on the different genomic and proteomic approaches used in forward chemical genetics to identify the molecular targets of the bioactive compounds, the advantages and disadvantages of each and a detailed list of successful examples of molecular targets identified with these approaches