11 research outputs found
A full degree-of-freedom photonic crystal spatial light modulator
Harnessing the full complexity of optical fields requires complete control of
all degrees-of-freedom within a region of space and time -- an open goal for
present-day spatial light modulators (SLMs), active metasurfaces, and optical
phased arrays. Here, we solve this challenge with a programmable photonic
crystal cavity array enabled by four key advances: (i) near-unity vertical
coupling to high-finesse microcavities through inverse design, (ii) scalable
fabrication by optimized, 300 mm full-wafer processing, (iii)
picometer-precision resonance alignment using automated, closed-loop
"holographic trimming", and (iv) out-of-plane cavity control via a high-speed
micro-LED array. Combining each, we demonstrate near-complete spatiotemporal
control of a 64-resonator, two-dimensional SLM with nanosecond- and
femtojoule-order switching. Simultaneously operating wavelength-scale modes
near the space- and time-bandwidth limits, this work opens a new regime of
programmability at the fundamental limits of multimode optical control.Comment: 25 pages, 20 figure
A full degree-of-freedom spatiotemporal light modulator
Harnessing the full complexity of optical fields requires complete control of all degrees-of-freedom within a region of space and time — an open goal for present-day spatial light modulators (SLMs), active metasurfaces, and optical phased arrays. Here, we solve this challenge with a programmable photonic crystal cavity array enabled by four key advances: (i) near-unity vertical coupling to high-finesse microcavities through inverse design, (ii) scalable fabrication by optimized, 300 mm full-wafer processing, (iii) picometer-precision resonance alignment using automated, closed-loop “holographic trimming”, and (iv) out-of-plane cavity control via a high-speed µLED array. Combining each, we demonstrate near-complete spatiotemporal control of a 64-resonator, two-dimensional SLM with nanosecond- and femtojoule-order switching. Simultaneously operating wavelength-scale modes near the space- and time-bandwidth limits, this work opens a new regime of programmability at the fundamental limits of multimode optical control
The AIM Photonics MPW: A Highly Accessible Cutting Edge Technology for Rapid Prototyping of Photonic Integrated Circuits
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis
Metastatic prostate cancer (PCa) is one of the leading causes of death from cancer in men. The molecular mechanisms underlying the transition from localized tumor to hormone-refractory metastatic PCa remain largely unknown, and their identification is key for predicting prognosis and targeted therapy. Here we demonstrated that increased expression of a splice variant of the Kruppel-like factor 6 (KLF6) tumor suppressor gene, known as KLF6-SV1, in tumors from men after prostatectomy predicted markedly poorer survival and disease recurrence profiles. Analysis of tumor samples revealed that KLF6-SV1 levels were specifically upregulated in hormone-refractory metastatic PCa. In 2 complementary mouse models of metastatic PCa, KLF6-SV1–overexpressing PCa cells were shown by in vivo and ex vivo bioluminescent imaging to metastasize more rapidly and to disseminate to lymph nodes, bone, and brain more often. Interestingly, while KLF6-SV1 overexpression increased metastasis, it did not affect localized tumor growth. KLF6-SV1 inhibition using RNAi induced spontaneous apoptosis in cultured PCa cell lines and suppressed tumor growth in mice. Together, these findings demonstrate that KLF6-SV1 expression levels in PCa tumors at the time of diagnosis can predict the metastatic behavior of the tumor; thus, KLF-SV1 may represent a novel therapeutic target