On the statistical evaluation of dose-response functions

The linear-quadratic dependence of effect on the dose of ionizing radiation and its biophysical implications are considered. The estimation of the parameters of the response function and the derivation of the joint confidence region of the estimates are described. The method is applied to the induction of pink mutations inTradescantia which follows the linear-quadratic model. The statistical procedure is also suitable for other response functions

Retreating to nature : rethinking 'therapeutic landscapes'

There is a long history of removing oneself from ‘society’ in order to recuperate or repair. This paper considers a yoga and massage retreat in Southern Spain, and what opportunities this retreat experience might offer for recuperation and the creation of healthy bodies. The paper positions ‘nature’ as an active participant, and as ‘enrolled’ in the experiences of the retreat as a ‘therapeutic landscape’, and questions how and what particular aspects of yoga practice (in intimate relation with place) give rise to therapeutic experiences

Reclaiming literacies: competing textual practices in a digital higher education

This essay examines the implications of the ubiquitous use of the term ‘digital literacies’ in higher education and its increasing alignment with institutional and organisational imperatives. It suggests that the term has been stripped of its provenance and association with disciplinary knowledge production and textual practice. Instead it is called into service rhetorically in order to promote competency based agendas both in and outside the academy. The piece also points to a tendency to position teachers in deficit with regard to their technological capabilities and pay scant attention to their own disciplinary and scholarly practices in a digital world. It concludes that there is a case for building on established theoretical and conceptual frameworks from literacy studies if we wish to integrate advantages of the digital landscape with thoughtful teaching practice

Photorespiration: metabolic pathways and their role in stress protection

Photorespiration results from the oxygenase reaction catalysed by ribulose-1,5-bisphosphate carboxylase/ oxygenase. In this reaction glycollate-2-phosphate is produced and subsequently metabolized in the photorespiratory pathway to form the Calvin cycle intermediate glycerate-3-phosphate. During this metabolic process, CO2 and NH3 are produced and ATP and reducing equivalents are consumed, thus making photorespiration a wasteful process. However, precisely because of this ine¤ciency, photorespiration could serve as an energy sink preventing the overreduction of the photosynthetic electron transport chain and photoinhibition, especially under stress conditions that lead to reduced rates of photosynthetic CO2 assimilation. Furthermore, photorespiration provides metabolites for other metabolic processes, e.g. glycine for the synthesis of glutathione, which is also involved in stress protection. In this review, we describe the use of photorespiratory mutants to study the control and regulation of photorespiratory pathways. In addition, we discuss the possible role of photorespiration under stress conditions, such as drought, high salt concentrations and high light intensities encountered by alpine plants

Working with simple machines

A set of examples is provided that illustrate the use of work as applied to simple machines. The ramp, pulley, lever and hydraulic press are common experiences in the life of a student and their theoretical analysis therefore makes the abstract concept of work more real. The mechanical advantage of each of these systems is also discussed so that students can evaluate their usefulness as machines.Comment: 9 pages, 4 figure

Microwave saturation of the Rydberg states of electrons on helium

We present measurements of the resonant microwave excitation of the Rydberg energy levels of surface state electrons on superfluid helium. The temperature dependent linewidth agrees well with theoretical predictions and is very small below 300 mK. Absorption saturation and power broadening were observed as the fraction of electrons in the first excited state was increased to 0.49, close to the thermal excitation limit of 0.5. The Rabi frequency was determined as a function of microwave power. The high values of the ratio of the Rabi frequency to linewidth confirm this system as an excellent candidate for creating qubits.Comment: 4 pages, 4 figure

Glucose effects on long-term memory performance : duration and domain specificity.

Rational; Previous research has suggested that long term- verbal declarative memory is particularly sensitive to enhancement by glucose loading, however investigation of glucose effects on certain memory domains has hitherto been neglected. Therefore domain specificity of glucose effects merits further elucidation. Objectives; The aim of the present research was to provide a more comprehensive investigation of the possible effects of glucose administration on different aspects of memory by i) contrasting the effect of glucose administration on different memory domains (implicit/ explicit memory; verbal/ non-verbal memory, recognition/ familiarity processes), ii) investigating whether potential effects on memory domains differ depending on the dose of glucose administered (25g versus 60g), iii) exploring the duration of the glucose facilitation effect (assessment of memory performance 35 min and 1 week after encoding). Methods; a double blind, between- subjects design was used to test the effects of administration of 25 and 60g glucose on memory performance. Results; Implicit memory was improved following administration of 60g of glucose. Glucose supplementation failed to improve face recognition performance but significantly improved performance of word recall and recognition following administration of 60g of glucose. However, effects were not maintained one-week following encoding. Conclusions; Improved implicit memory performance following glucose administration has not been reported before. Furthermore the current data tentatively suggest that level of processing may determine the required glucose dosage to demonstrate memory improvement and that higher dosages may be able to exert effects on memory pertaining to both hippocampal and non-hippocampal brain regions

3C 295, a cluster and its cooling flow at z=0.46

We present ROSAT HRI data of the distant and X-ray luminous (L_x(bol)=2.6^ {+0.4}_{-0.2} 10^{45}erg/sec) cluster of galaxies 3C 295. We fit both a one-dimensional and a two-dimensional isothermal beta-model to the data, the latter one taking into account the effects of the point spread function (PSF). For the error analysis of the parameters of the two-dimensional model we introduce a Monte-Carlo technique. Applying a substructure analysis, by subtracting a cluster model from the data, we find no evidence for a merger, but we see a decrement in emission South-East of the center of the cluster, which might be due to absorption. We confirm previous results by Henry & Henriksen(1986) that 3C 295 hosts a cooling flow. The equations for the simple and idealized cooling flow analysis presented here are solely based on the isothermal beta-model, which fits the data very well, including the center of the cluster. We determine a cooling flow radius of 60-120kpc and mass accretion rates of dot{M}=400-900 Msun/y, depending on the applied model and temperature profile. We also investigate the effects of the ROSAT PSF on our estimate of dot{M}, which tends to lead to a small overestimate of this quantity if not taken into account. This increase of dot{M} (10-25%) can be explained by a shallower gravitational potential inferred by the broader overall profile caused by the PSF, which diminishes the efficiency of mass accretion. We also determine the total mass of the cluster using the hydrostatic approach. At a radius of 2.1 Mpc, we estimate the total mass of the cluster (M{tot}) to be (9.2 +/- 2.7) 10^{14}Msun. For the gas to total mass ratio we get M{gas}/M{tot} =0.17-0.31, in very good agreement with the results for other clusters of galaxies, giving strong evidence for a low density universe.Comment: 26 pages, 7 figures, accepted for publication in Ap