123 research outputs found

    Large Adjustable Speed Drives And Their Application To A High Speed Centrifugal Compressor

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    PaperPg. 81-85.New applications are being found for adjustable speed drives due to: 1) the availability of high current solid-state devices, 2) a simplified inverter design with large scale integrated circuits (LSI), and 3) because of the growing need for energy conservation. Several types of drives and their application to a high speed compressor will be described in this paper. The drives most suitable to high horsepower applications are: 1) the slip recovery drive (Scherbius), 2) the brushless DC system (synchro-converter) and 3) the current source inverter

    Convectively Induced Secondary Circulations in Fine-Grid Mesoscale Numerical Weather Prediction Models

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    Mesoscale numerical weather prediction models using fine-grid [O(1) km] meshes for weather forecasting, environmental assessment, and other applications capture aspects of larger-than-grid-mesh size, convectively induced secondary circulations (CISCs) such as cells and rolls that occur in the convective planetary boundary layer (PBL). However, 1-km grid spacing is too large for the simulation of the interaction of CISCs with smaller-scale turbulence. The existence of CISCs also violates the neglect of horizontal gradients of turbulent quantities in current PBL schemes. Both aspects—poorly resolved CISCs and a violation of the assumptions behind PBL schemes—are examples of what occurs in Wyngaard’s “terra incognita,” where horizontal grid spacing is comparable to the scale of the simulated motions. Thus, model CISCs (M-CISCs) cannot be simulated reliably. This paper describes how the superadiabatic layer in the lower convective PBL together with increased horizontal resolution allow the critical Rayleigh number to be exceeded and thus allow generation of M-CISCs like those in nature; and how the M-CISCs eventually neutralize the virtual temperature stratification, lowering the Rayleigh number and stopping their growth. Two options for removing M-CISCs while retaining their fluxes are 1) introducing nonlocal closure schemes for more effective removal of heat from the surface and 2) restricting the effective Rayleigh number to remain subcritical. It is demonstrated that CISCs are correctly handled by large-eddy simulation (LES) and thus may provide a way to improve representation of them or their effects. For some applications, it may suffice to allow M-CISCs to develop, but account for their shortcomings during interpretation

    Interleukin 7 from Maternal Milk Crosses the Intestinal Barrier and Modulates T- Cell Development in Offspring

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    Background Breastfeeding protects against illnesses and death in hazardous environments, an effect partly mediated by improved immune function. One hypothesis suggests that factors within milk supplement the inadequate immune response of the offspring, but this has not been able to account for a series of observations showing that factors within maternally derived milk may supplement the development of the immune system through a direct effect on the primary lymphoid organs. In a previous human study we reported evidence suggesting a link between IL-7 in breast milk and the thymic output of infants. Here we report evidence in mice of direct action of maternally-derived IL-7 on T cell development in the offspring. Methods and Findings  We have used recombinant IL-7 labelled with a fluorescent dye to trace the movement in live mice of IL-7 from the stomach across the gut and into the lymphoid tissues. To validate the functional ability of maternally derived IL- 7 we cross fostered IL-7 knock-out mice onto normal wild type mothers. Subsets of thymocytes and populations of peripheral T cells were significantly higher than those found in knock-out mice receiving milk from IL-7 knock-out mothers. Conclusions/Significance Our study provides direct evidence that interleukin 7, a factor which is critical in the development of T lymphocytes, when maternally derived can transfer across the intestine of the offspring, increase T cell production in the thymus and support the survival of T cells in the peripheral secondary lymphoid tissue
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