Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina

We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions. The clinical surfactant Curosurf, both native and extruded, and a protein-free surfactant are investigated. The phase behavior of mixed surfactant/particle dispersions was determined by optical and electron microscopy, light scattering and zeta potential measurements. It exhibits broad similarities with that of strongly interacting nanosystems such as polymers, proteins or particles, and supports the hypothesis of electrostatic complexation. At a critical stoichiometry, micron sized aggregates arising from the association between oppositely charged vesicles and nanoparticles are formed. Contrary to the models of lipoprotein corona or of particle wrapping, our work shows that vesicles maintain their structural integrity and trap the particles at their surfaces. The agglomeration of particles in surfactant phase is a phenomenon of importance since it could change the interactions of the particles with lung cells.Comment: 19 pages 9 figure

Very High-Redshift Lensed Galaxies

We review in this paper the main results recently obtained on the identification and study of very high-z galaxies usinglensing clusters as natural gravitational telescopes. We present in detail our pilot survey with ISAAC/VLT, aimed at the detection of z>7 sources. Evolutionary synthesis models for extremely metal-poor and PopIII starbursts have been used to derive the observational properties expected for these high-z galaxies, such as expected magnitudes and colors, line fluxes for the main emission lines, etc. These models have allowed to define fairly robust selection criteria to find z~7-10 galaxies based on broad-band near-IR photometry in combination with the traditional Lyman drop-out technique. The first results issued from our photometric and spectroscopic survey are discussed, in particular the preliminary confirmation rate, and the global properties of our high-z candidates, including the latest results on the possible z=10.0 candidate A1835-1916. The search efficiency should be significantly improved by the future near-IR multi-object ground-based and space facilities. However, strong lensing clusters remain a factor of ~5-10 more efficient than blank fields in this redshift domain, within the FOV of a few arcminutes around the cluster core, for the typical depth required for this survey project.Comment: 14 pages, 7 figures, Proceedings of IAU Symposium No. 225: The Impact of Gravitational Lensing on Cosmology, Y. Mellier and G. Meylan, Ed

ISAAC/VLT observations of a lensed galaxy at z=10.0

We report the first likely spectroscopic confirmation of a z 10.0 galaxy from our ongoing search for distant galaxies with ISAAC/VLT. Galaxy candidates at z >~ 7 are selected from ultra-deep JHKs images in the core of gravitational lensing clusters for which deep optical imaging is also available, including HST data. The object reported here, found behind Abell 1835, exhibits a faint emission line detected in the J band, leading to z=10.0 when identified as Ly-a, in excellent agreement with the photometric redshift determination. Redshifts z < 7 are very unlikely for various reasons we discuss. The object is located on the critical lines corresponding to z=9 to 11. The magnification factor \mu ranges from 25 to 100. For this object we estimate SFR(Ly-a) (0.8-2.2) Msun/yr and SFR(UV) (47-75) Msun/yr, both uncorrected for lensing. The steep UV slope indicates a young object with negligible dust extinction. SED fits with young low-metallicity stellar population models yield (adopting mu=25) a lensing corrected stellar mass of M*~8.e+6 Msun, and luminosities of 2.e+10 Lsun, corresponding to a dark matter halo of a mass of typically M_tot>~ 5.e+8 Msun. In general our observations show that under excellent conditions and using strong gravitational lensing direct observations of galaxies close to the ``dark ages'' are feasible with ground-based 8-10m class telescopes.Comment: To be published in A&A, Vol. 416, p. L35. Press release information, additional figures and information available at http://obswww.unige.ch/sfr and http://webast.ast.obs-mip.fr/galaxie

A ring galaxy at z=1 lensed by the cluster Abell 370

We present a study of a very peculiar object found in the field of the cluster-lens Abell 370. This object displays, in HST imaging, a spectacular morphology comparable to nearby ring-galaxies. From spectroscopic observations at the CFHT, we measured a redshift of $z=1.062$ based on the identification of [O ii] 3727 \AA and [Ne v] 3426 \AA emission lines. These emission lines are typical of starburst galaxies hosting a central active nucleus and are in good agreement with the assumption that this object is a ring-galaxy. This object is also detected with ISO in the LW2 and LW3 filters, and the mid Infra-Red (MIR) flux ratio favors a Seyfert 1 type. The shape of the ring is gravitationally distorted by the cluster-lens, and most particularly by a nearby cluster elliptical galaxy. Using the cluster mass model, we can compute its intrinsic shape. Requiring that the outer ring follows an ellipse we put constraints on the M/L ratio of the nearby galaxy and derive a magnification factor of 2.5 $\pm$ 0.2. The absolute luminosities of the source are then $L_B = 1.3 \ 10^{12} L_{B \odot}$and$\nu$L$_\nu \simeq 4. 10^{10}$L$_\odot$ in the mid-IR.Comment: 5 pages, 5 figures, uses aa.cls, accepted to A&A Letters. Minor changes, Figure 1 revisited and typos adde

Effect of Gravitational Lensing on Measurements of the Sunyaev-Zel'dovich Effect

The Sunyaev-Zel'dovich (SZ) effect of a cluster of galaxies is usually measured after background radio sources are removed from the cluster field. Gravitational lensing by the cluster potential leads to a systematic deficit in the residual intensity of unresolved sources behind the cluster core relative to a control field far from the cluster center. As a result, the measured decrement in the Rayleigh-Jeans temperature of the cosmic microwave background is overestimated. We calculate the associated systematic bias which is inevitably introduced into measurements of the Hubble constant using the SZ effect. For the cluster A2218, we find that observations at 15 GHz with a beam radius of 0'.4 and a source removal threshold of 100 microJy underestimate the Hubble constant by 6-10%. If the profile of the gas pressure declines more steeply with radius than that of the dark matter density, then the ratio of lensing to SZ decrements increases towards the outer part of the cluster.Comment: 11 pages, 3 figures, submitted to ApJ