Choice and information in the public sector: a Higher Education case study

Successive governments have encouraged the view of users of public services as consumers, choosing between different providers on the basis of information about the quality of service. As part of this approach, prospective students are expected to make their decisions about which universities to apply to with reference to the consumer evaluations provided by the National Student Survey. However, a case study of a post-1992 university showed that not all students made genuine choices and those who did tended to be in stronger social and economic positions. Where choices were made, they were infrequently based on external evaluations of quality

Tunable mechanically-induced hysteresis in suspended Josephson junctions

The coupling of superconducting systems to mechanical resonators is an emerging field, with wide reaching implications including high precision sensing and metrology. Experimental signatures of this coupling have so far been small, seldom and often reliant on high frequency AC electronics. To overcome this limitation, in this work we consider a mechanical resonator suspended between two superconducting contacts to form a suspended Josephson junction in which the electronic normal- and super-currents can be coupled to mechanical motion via the Lorentz force due to an external magnetic field. We show both analytically and numerically that this electro-mechanical coupling produces unprecedented mechanically-induced hysteresis loops in the junction's DC I-V characteristic. Firstly, we unveil how this new hysteresis may be exploited to access a huge mechanically-induced Shapiro-like voltage plateau, extending over a current range comparable with the junction's critical current. We then investigate a sudden mechanically-induced retrapping that occurs at strong coupling. Our analytical treatment provides a clear explanation for the effects above and allows us to derive simple relationships between the features in the DC I-V characteristic and the resonance frequency and quality factor of the mechanical resonator. We stress that our setup requires only DC current bias and voltage measurements, allowing the activation and detection of high-frequency mechanical oscillations in state of the art devices and without the need of any AC equipment

Understanding the Impact of Technology: Learner and School Level Factors

The first part of this report focuses on the factors impacting on learner performance in national tests at primary and secondary level. This was the central research question of this research. The second section focuses on teacher and learner perceptions of their own responses to learning and the learning environment. This was centred on, but not confined to, their school. The institutional structures record the level of development of the schools sampled here and investigate the use of two key technologies – interactive whiteboards and learning platform

Feeling alone among 317 million others:Disclosures of loneliness on Twitter

Increasing numbers of individuals describe themselves as feeling lonely, regardless of age, gender or geographic location. This article investigates how social media users self-disclose feelings of loneliness, and how they seek and provide support to each other. Motivated by related studies in this area, a dataset of 22,477 Twitter posts sent over a one-week period was analyzed using both qualitative and quantitative methods. Through a thematic analysis, we demonstrate that self-disclosure of perceived loneliness takes a variety of forms, from simple statements of “I’m lonely”, through to detailed self-reflections of the underlying causes of loneliness. The analysis also reveals forms of online support provided to those who are feeling lonely. Further, we conducted a quantitative linguistic content analysis of the dataset which revealed patterns in the data, including that ‘lonely’ tweets were significantly more negative than those in a control sample, with levels of negativity fluctuating throughout the week and posts sent at night being more negative than those sent in the daytime

Water and Sanitation in Schools: A Systematic Review of the Health and Educational Outcomes

A systematic review of the literature on the effects of water and sanitation in schools was performed. The goal was to characterize the impacts of water and sanitation inadequacies in the academic environment. Published peer reviewed literature was screened and articles that documented the provision of water and sanitation at schools were considered. Forty-one peer-reviewed papers met the criteria of exploring the effects of the availability of water and/or sanitation facilities in educational establishments. Chosen studies were divided into six fields based on their specific foci: water for drinking, water for handwashing, water for drinking and handwashing, water for sanitation, sanitation for menstruation and combined water and sanitation. The studies provide evidence for an increase in water intake with increased provision of water and increased access to water facilities. Articles also report an increase in absenteeism from schools in developing countries during menses due to inadequate sanitation facilities. Lastly, there is a reported decrease in diarrheal and gastrointestinal diseases with increased access to adequate sanitation facilities in schools. Ensuring ready access to safe drinking water, and hygienic toilets that offer privacy to users has great potential to beneficially impact children’s health. Additional studies that examine the relationship between sanitation provisions in schools are needed to more adequately characterize the impact of water and sanitation on educational achievements

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues

<p>Abstract</p> <p>Background</p> <p>It has been well established that prolactin (PRL) signals through the long form of its receptor (PRL-RL) and activates the Jak/Stat pathway for transcription of PRL target genes. However, signaling pathways mediated through the short PRL-R isoform (PRL-RS) remains controversial. Our recent finding that PRL signaling through PRL-RS represses two transcription factors critical for follicular development lead us to examine other putative PRL/PRL-RS target transcription factors in the decidua and ovary, two well-known target tissues of PRL action in reproduction.</p> <p>Methods</p> <p>In this investigation we used mice expressing PRL-RS on a PRL-R knockout background and a combo protein/DNA array to study the transcription factors regulated by PRL through PRL-RS only.</p> <p>Results</p> <p>We show that PRL activation of the PRL-RS receptor either stimulates or inhibits the DNA binding activity of a substantial number of transcription factors in the decidua as well as ovary. We found few transcription factors to be similarly regulated in both tissues, while most transcription factors are oppositely regulated by PRL in the decidua and ovary. In addition, some transcription factors are regulated by PRL only in the ovary or only in the decidua. Several of these transcription factors are involved in physiological pathways known to be regulated by PRL while others are novel.</p> <p>Conclusion</p> <p>Our results clearly indicate that PRL does signal through PRL-RS in the decidua as well as the ovary, independently of PRL-RL, and activates/represses transcription factors in a tissue specific manner. This is the first report showing PRL/PRL-RS regulation of specific transcription factors. Many of these transcription factors were not previously known to be PRL targets, suggesting novel physiological roles for this hormone.</p

AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving

BACKGROUND: The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (CP-AMPARs). Through metabotropic glutamate receptor 1 (mGluR1)-mediated synaptic depression, mGluR1 positive allosteric modulators remove CP-AMPARs from these synapses and thereby reduce cocaine craving. This study aimed to determine if similar plasticity accompanies incubation of methamphetamine craving. METHODS: Rats self-administered saline or methamphetamine under extended-access conditions. Cue-induced seeking tests demonstrated incubation of methamphetamine craving. After withdrawal periods ranging from 1 to \u3e40 days, rats underwent one of the following procedures: 1) whole-cell patch clamp recordings to characterize AMPAR transmission, 2) intra-NAc core injection of the CP-AMPAR antagonist 1-naphthyl acetyl spermine followed by a seeking test, or 3) systemic administration of a mGluR1 positive allosteric modulator followed by a seeking test. RESULTS: Incubation of methamphetamine craving was associated with CP-AMPAR accumulation in NAc core, and both effects were maximal after ~1 week of withdrawal. Expression of incubated craving was decreased by intra-NAc core 1-naphthyl acetyl spermine injection or systemic mGluR1 positive allosteric modulator administration. CONCLUSIONS: These results are the first to demonstrate a role for the NAc in the incubation of methamphetamine craving and describe adaptations in synaptic transmission associated with this model. They establish that incubation of craving and associated CP-AMPAR plasticity occur much more rapidly during withdrawal from methamphetamine compared with cocaine. However, a common mGluR1-based therapeutic strategy may be helpful for recovering cocaine and methamphetamine addicts