Long-term dynamics of Methone, Anthe and Pallene

We numerically investigate the long-term dynamics of the Saturn's small satellites Methone (S/2004 S1), Anthe (S/2007 S4) and Pallene (S/2004 S2). In our numerical integrations, these satellites are disturbed by non-spherical shape of Saturn and the six nearest regular satellites. The stability of the small bodies is studied here by analyzing long-term evolution of their orbital elements. We show that long-term evolution of Pallene is dictated by a quasi secular resonance involving the ascending nodes ($\Omega$) and longitudes of pericentric distances ($\varpi$) of Mimas (subscript 1) and Pallene (subscript 2), which critical argument is $\varpi_2-\varpi_1-\Omega_1+\Omega_2$. Long-term orbital evolution of Methone and Anthe are probably chaotic since: i) their orbits randomly cross the orbit of Mimas in time scales of thousands years); ii) numerical simulations involving both small satellites are strongly affected by small changes in the initial conditions.Comment: 9 pages; 4 figures. Submitted to Proceedings IAU Symposium No. S263, 200

Circadian rhythm dysfunction in glaucoma: A hypothesis

The absence of circadian zeitgebers in the social environment causes circadian misalignment, which is often associated with sleep disturbances. Circadian misalignment, defined as a mismatch between the sleep-wake cycle and the timing of the circadian system, can occur either because of inadequate exposure to the light-dark cycle, the most important synchronizer of the circadian system, or reduction in light transmission resulting from ophthalmic diseases (e.g., senile miosis, cataract, diabetic retinopathy, macular degeneration, retinitis pigmentosa, and glaucoma). We propose that glaucoma may be the primary ocular disease that directly compromises photic input to the circadian time-keeping system because of inherent ganglion cell death. Glaucomatous damage to the ganglion cell layer might be particularly harmful to melanopsin. According to histologic and circadian data, a subset of intrinsically photoresponsive retinal ganglion cells, expressing melanopsin and cryptochromes, entrain the endogenous circadian system via transduction of photic input to the thalamus, projecting either to the suprachiasmatic nucleus or the lateral geniculate nucleus. Glaucoma provides a unique opportunity to explore whether in fact light transmission to the circadian system is compromised as a result of ganglion cell loss

AVAST Survey 0.4-1.0 {\mu}m Spectroscopy of Igneous Asteroids in the Inner and Middle Main Belt

We present the spectra of 60 asteroids, including 47 V-types observed during the first phase of the Adler V-Type Asteroid (AVAST) Survey. SDSS photometry was used to select candidate V-type asteroids for follow up by nature of their very blue $i-z$ color. 47 of the 61 observed candidates were positively classified as V-type asteroids, while an additional six show indications of a 0.9 $\mu$m feature consistent with V-type spectra, but not sufficient for formal classification. Four asteroids were found to be S-type, all of which had $i-z$ values very near the adopted AVAST selection criteria of $i-z \le -0.2$, including one candidate observed well outside the cut (at a mean $i-z$ of -0.11). Three A-type asteroids were also identified. Six V-type asteroids were observed beyond the 3:1 mean motion resonance with Jupiter, including the identification of two new V-type asteroids (63085 and 105041) at this distance. Six V-type asteroids were observed with low ($<5\deg$) orbital inclination, outside of the normal dynamical range of classic Vestoids, and are suggestive of a non-Vesta origin for at least some of the population.Comment: 1 table, 3 figures, To appear to Icaru

The incidence of alien species on the taxonomic, phylogenetic, and functional diversity of lentic and lotic communities dominated by Phragmites australis (Cav.) Steud

This study aims to investigate, for the first time, the multiple diversity harbored in plant communities dominated by P. australis, discriminating between lentic and lotic habitats. We focused on the incidence of alien species on taxonomical, phylogenetic and functional diversity. Although it was hypothesized that ecological differences between habitats (lentic vs. lotic) could lead to plant adaptive trade-offs, results showed that the P. australis dominance affected overall plant diversity in the same way in both target habitats. Similarly, the two compared habitats hosted a similar alien species richness and relative abundance. Different results were observed based on whether the alien species richness or their relative abundance were considered regarding the incidence of alien species. Increasing alien species richness in lentic habitats resulted in increased taxonomic, phylogenetic and functional diversity. Instead, in lotic habitats, it promoted a decrease in taxonomic and functional diversity. In contrast, the increase in the relative abundance of alien species resulted in increased taxonomic, phylogenetic and functional diversity in both habitats. Choosing relative abundance vs richness of aliens in lotic stands can have a different impact in evaluating the effect of aliens on various components of diversity

Single and Compound Knock-outs of MicroRNA (miRNA)-155 and Its Angiogenic Gene Target CCN1 in Mice Alter Vascular and Neovascular Growth in the Retina via Resident Microglia

The response of the retina to ischemic insult typically leads to aberrant retinal neovascularization, a major cause of blindness. The epigenetic regulation of angiogenic gene expression by miRNAs provides new prospects for their therapeutic utility in retinal neovascularization. Here, we focus on miR-155, a microRNA functionally important in inflammation, which is of paramount importance in the pathogenesis of retinal neovascularization. Whereas constitutive miR-155-deficiency in mice results in mild vascular defects, forced expression of miR-155 causes endothelial hyperplasia and increases microglia count and activation. The mouse model of oxygen-induced retinopathy, which recapitulates ischemia-induced aberrant neovessel growth, is characterized by increased expression of miR-155 and localized areas of microglia activation. Interestingly, miR-155 deficiency in mice reduces microglial activation, curtails abnormal vessel growth, and allows for rapid normalization of the retinal vasculature following ischemic insult. miR-155 binds to the 3'-UTR and represses the expression of the CCN1 gene, which encodes an extracellular matrix-associated integrin-binding protein that both promotes physiological angiogenesis and harnesses growth factor-induced abnormal angiogenic responses. Single CCN1 deficiency or double CCN1 and miR-155 knock-out in mice causes retinal vascular malformations typical of faulty maturation, mimicking the vascular alterations of miR-155 gain of function. During development, the miR-155/CCN1 regulatory axis balances the proangiogenic and proinflammatory activities of microglia to allow for their function as guideposts for sprout fusion and anastomosis. Under ischemic conditions, dysregulated miR-155 and CCN1 expression increases the inflammatory load and microglial activation, prompting aberrant angiogenic responses. Thus, miR-155 functions in tandem with CCN1 to modulate inflammation-induced vascular homeostasis and repair

Effects of Craniofacial Structures on Mouse Palatal Closure In Vitro

Heads of Swiss-Webster mouse fetuses of four ages spanning days 12-13 of gestation, were partially dissected by removing the brain (B), tongue (T) and mandible (M) alone or in combination (BT, BM, BTM). Preparations were suspended in a gassed, circulating culture system such that palatal closure must take place against gravity. Closure occurred earlier than in vivo and required the posterior half of the mandible be intact and the tongue removed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68249/2/10.1177_00220345780570024401.pd