31 research outputs found
Nucleoside analogues synthesis using natural phosphate doped with I2 (NP/I2) in HMDS
Several D-ribonucleosides are prepared from1-O-acetyl-2,3,5-tri-O-benzoyl-?-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using natural phosphate doped with I2 as catalyst Keywords: Natural Phosphate doped with I2, one-step seynthesis. ?/?-D-ribonucleoside
Novel approach to Synthesis of Pentofurano nucleoside assisted natural phosphate doped with CF3SO3H as catalyst
This article describes a method for the preparation of ribonucleosides using the solid-phase approach. Several D-ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-?-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using natural phosphate doped with CF3SO3H (NP/ CF3SO3H) as catalyst. Keywords: Natural phosphate, CF3SO3H, D-Ribonucleoside
Heterogeneous Solid-Liquid Catalysis Of N-glycosylation By Natural Phosphate Doped With Potassium Iodide
Theone-step synthesis of several ?-D-ribonucleosides was performed in good yields under reflux in HMDS. Keywords: N-Glycosylation D-ribonucleosides,Natural phosphate doped with Potassium iodide KI (NP/KI), heterogeneous solid-liquid catalysi
Applications of Microwave in Organic Synthesis: A One-step Synthesis of Ribonucleosides using natural phosphate as solid catalyst
A clean, efficient and fast method for synthesis of ribonucleosides was developed, using natural phosphate as solid catalyst catalysts supported in a solid phase promoted by MW irradiation. Keywords: Natural phosphate, Ribonucleosides , Micowave irradiation
Catalytic And Economic Method Using As Catalyst the I-Si(CH3)3 Generated During The Condensation Of Silylated Base With Natural Phosphate Doped With KI (NP/KI)
Several D-ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-?-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using as catalyst I-Si(CH3)3 generated during the condensation of silylated base with NP/KI. Keywords: I-Si(CH3)3 generated during the condensation of silylated base with NP/KI,one-step synthesis, and D-ribonucleosides
A New Selective Synthesis Of D-Ribonucleosides In Acetonitrile With BSA Using NP/KI As Catalyst
The one-step synthesis of several ?-D-ribonucleosides was performed in good yields under reflux. Keywords: D-nucleosides, natural phosphate, catalyst, one-step seynthesis
2-({4-[4-(1H-Benzimidazol-2-yl)phenyl]-1H-1,2,3-triazol-1-yl}methoxy)ethanol
In the title molecule, C18H17N5O2, the dihedral angle between the benzene plane and the benzimidazole plane is 19.8 (1)° and the angle between the benzene plane and the triazole plane is 16.7 (1)°. In the crystal, molecules are connected by O—H⋯N hydrogen bonds, forming zigzag chains along the c-axis direction. The chains are connected by bifurcated N—H⋯(N,N) hydrogen bonds into layers parallel to (100). These layers are connected along the a-axis direction by weak C—H⋯O contacts, forming a three-dimensional network
4-(4-{[(2-Phenylquinazolin-4-yl)oxy]methyl}-1H-1,2,3-triazol-1-yl)butan-1-ol hemihydrate
The title compound, C21H21N5O2·0.5H2O, has two fused six-membered rings linked to a benzene ring and to a triazole ring, which is connected to a butanol group. The quinazoline ring forms a dihedral angle of 7.88 (8)° with the benzene ring, while the triazole ring is approximately perpendicular to the benzene ring and to the quinazoline system, making dihedral angles of 84.38 (10) and 76.55 (8)°, respectively. The stereochemical arrangement of the butanol chain, with a C—C—C—C torsion angle of 178.34 (19)°, corresponds to an antiperiplanar conformation. However the position of the –OH group is split into two very close [O—O = 0.810(3) Å] positions of equal occupancy. The crystal structure features O—H⋯N and O—H⋯O hydrogen bonds, building an infinite three-dimensional network. The water molecule is located on a half-filled general position
4-{4-[(4-Oxoquinazolin-3-yl)methyl]-1H-1,2,3-triazol-1-yl}butyl acetate
In the heterocyclic title compound, C17H19N5O3, the quinazolinone ring system forms a dihedral angle of 67.22 (7)° with the triazole ring. The butyl acetate group has a non-linear conformation, with an alternation of synclinal and antiperiplanar torsion angles [N—C—C—C = 58.5 (2)°, C—C—C—C = 170.72 (19)° and C—C—C—O = −65.9 (3)°]. The crystal structure features intermolecular C—H⋯N and C—H⋯O non-classical hydrogen bonds, building an infinite one-dimensional network along the [100] direction