Solar plasma experiment

Solar plasma experiment by Mariner IV space prob

Screening for Thyroid Dysfunction in Pregnancy: Is It Worthwhile?

There is a high incidence of thyroid dysfunction during pregnancy resulting in adverse maternal (miscarriages, anaemia in pregnancy, preeclampsia, abruptio placenta and post-partum haemorrhage) and fetal effects (premature birth, low birth weight, increased neonatal respiratory distress) which may justify screening for thyroid function during early pregnancy with interventional levothyroxine therapy for thyroid hypofunction. There is a greater prevalence of subclinical hypothyroidism in women with delivery before 32 weeks and there is even an association between thyroid autoimmunity and adverse obstetric outcome, which is independent of thyroid function. Higher maternal TSH levels even within the normal reference range are associated with an increased risk of miscarriages, fetal and neonatal distress and preterm delivery. There are few prospective randomised trials to substantiate the benefit of screening and the recently reported CATS study did not show a benefit in child IQ at age 3 years. Nevertheless there seems to be a case for screening to prevent adverse obstetric outcomes. The clinical epidemiological evidence base does not justify universal screening at the present time. However, it is probable that more evidence will be produced which may alter this view in the future

clues: An R Package for Nonparametric Clustering Based on Local Shrinking

Determining the optimal number of clusters appears to be a persistent and controversial issue in cluster analysis. Most existing R packages targeting clustering require the user to specify the number of clusters in advance. However, if this subjectively chosen number is far from optimal, clustering may produce seriously misleading results. In order to address this vexing problem, we develop the R package clues to automate and evaluate the selection of an optimal number of clusters, which is widely applicable in the field of clustering analysis. Package clues uses two main procedures, shrinking and partitioning, to estimate an optimal number of clusters by maximizing an index function, either the CH index or the Silhouette index, rather than relying on guessing a pre-specified number. Five agreement indices (Rand index, Hubert and ArabieâÂÂs adjusted Rand index, Morey and AgrestiâÂÂs adjusted Rand index, Fowlkes and Mallows index and Jaccard index), which measure the degree of agreement between any two partitions, are also provided in clues. In addition to numerical evidence, clues also supplies a deeper insight into the partitioning process with trajectory plots.

Goitre and Iodine Deficiency in Europe

The prevalence of endemic iodine-deficiency goitre in Europe has been reduced in many areas by the introduction of iodination programmes. Recent reports, however, show that goitre remains a significant problem and that its prevalence has not decreased in a number of European countries. Hetzel1 has pointed out that the high global prevalence of iodine-deficiency disorders could be eradicated within 5-10 years by introduction of an iodised salt programme. The current World Health Organisation recommendations for iodine intake are between 150 and 300 μg/da

Effects of Some Coding Techniques On Multicolinearity and Model Statistics

Two known methods of coding data for analyses in the presence of multicollinearity and evaluation of model performance viz: Dummy coding and Effect coding which are alternatives to each other were considered. Efforts were made to improve on their performances by modifying them as modified Dummy coding and modified Effect coding respectively and their performances of the now coding methods compared in this paper. The results show that all coding methods significantly reduced the effect of multicollinearity. The effect coding was found to be the best coding method in remedying multicollinearity while closely followed by the dummy coding. However, the proposed modified dummy coding gave the best R-squared values as well as F-values while still reducing the effect of multicollinearity to a great extent and closely followed by modified effect coding. The dummy and effect coding methods proved very efficient in remedying multicollinearity as their observed variance inflation factor (VIF) were all close to unity. Keywords: Dummy coding, effect coding, multicollinearity, variance inflation factor

Failure mechanisms and surface roughness statistics of fractured Fontainebleau sandstone

In an effort to investigate the link between failure mechanisms and the geometry of fractures of compacted grains materials, a detailed statistical analysis of the surfaces of fractured Fontainebleau sandstones has been achieved. The roughness of samples of different widths W is shown to be self affine with an exponent zeta=0.46 +- 0.05 over a range of length scales ranging from the grain size d up to an upper cut-off length \xi = 0.15 W. This low zeta value is in agreement with measurements on other sandstones and on sintered materials. The probability distributions P(delta z,delta h) of the variations of height over different distances delta z > d can be collapsed onto a single Gaussian distribution with a suitable normalisation and do not display multifractal features. The roughness amplitude, as characterized by the height-height correlation over fixed distances delta z, does not depend on the sample width, implying that no anomalous scaling of the type reported for other materials is present. It is suggested, in agreement with recent theoretical work, to explain these results by the occurence of brittle fracture (instead of damage failure in materials displaying a higher value of zeta = 0.8).Comment: 7 page