Genetic Variability in Different Lucerne (\u3cem\u3eMedicago Sativa\u3c/em\u3e) Genotypes

One of the basic goals of modern lucerne breeding programmes is creation of new cultivars with a great potential for high quality and stable yields of both forage and hay (Riday & Brummer, 2002). Such cultivars meet increased needs of animal husbandry and must contribute to diverse farming systems (Luki , 2000). Our trial was aimed at determining genetic variability of yield components in 7 lucerne genotypes, as well as at evaluation of their breeding potential as gene donors to new lucerne cultivar

Integration of the energy efficiency into the local development strategies

Balanced Scorecards represent powerful management tool for describing, explaining, representing and implementing different business strategies. Being in use for more than two decades, this tool proved its applicability in public, private and non-profit enterprises, which makes it suitable for applying in local development plans. The municipality of Sayski Venac applied balanced scorecards as decision-making tools to structure its objectives and articulate them into the strategy. However, the energy efficiency, although perceived as a national priority, was not included in the developed municipality strategy map. This paper investigates the possibilities to integrate the energy efficiency objectives and the municipality strategic objectives, in order to identify and apply proper key performance indicators, targets and measures to improve energy efficiency in different sectors. The ultimate goal is to propose proper GHG mitigation measures to enhance energy efficiency that will fit within the local development strategy of the municipality of Sayski Venac, to align the energy efficiency measures with its energy policy, to improve the selection process of the energy efficiency measures and to adjust it to the municipality needs

Efekat perkutane koronarne intervencije na prognozu sa akutnim infarktom miokarda bez ST elevacije

Introduction: Data suggest that the prevalence of non ST segment elevation acute coronary syndromes (NSTE-ACS) is higher than that of ST segment elevation myocardial infarction (MI) (STEMI), intrahospital mortality is higher in STEMI, but higher in NSTE-ACS compared to STEMI after 4 years. The aim of the present study is to investigate the effects of percutaneous coronary intervention (PCI) on outcomes in patients with non ST segment elevation MI (NSTEMI). Patients and methods: The present study included 185 patients who survived MI (A group, patients with NSTEMI, treated with PCI and drugs, B group, patients with STEMI, treated with PCI and drugs and C group, patients with NSTEMI, treated with drugs only). An effect of PCI, as well as the predictive value of markers of necrosis, inflammation, renal function, heart failure on intrahospital and posthospital outcomes were investigated. Results: Intrahospital complications appeared more frequently in B group, while posthospital complications, including angina pectoris, hemodynamic instability and MACE (death, reinfarction and coronary artery bypass grafting) appeared more frequently in C group. The strongest predictors of death were the C group, female sex, patients who already suffered from MI, heart rate on admission, glycated hemoglobin, urea and creatinine. Conclusions: The strongest predictors of death were age and heart rate on admission. The average time of survival was significantly shorter in C group, compared to both A and B groups. However, it was not significantly different between A and B groups

Laboratorijske analize krvnog seruma i urina pasa sa akutnom renalnom insuficijencijom izazvanom gentamicinom

The use of aminoglucoside antibiotics can be a potential risk for renal parenchyma damage and consequently acute renal failure (ARF). ARF is a syndrome that develops from progressive nephron damage resulting in the loss of renal function. Numerous experimental models have been used to study acute renal failure mainly describing histo-pathological changes in the structure of this organ. Our investigations were conducted in order to evaluate the functional capacity of kidneys in dogs with ARF induced by application of gentamicin in high doses of 80 mg/kg/24 , during 7 days. For that purpose, physico-chemical properties of the urine, concentrations of relevant parameters in the sera and urine and endogenous creatinine clearance were estimated. Our results indicate that gentamicin, in doses 20 times higher than therapeutic ones, causes progressive ARF starting from the 3 day of application.Pod određenim uslovima upotreba aminoglukozidnih antibiotika može predstavljati potencijalni rizik za nastanak oštećenja u parenhimu bubrega i posledične akutne renalne insuficijencije (ARI). ARI je sindrom koji nastaje usled progresivnog propadanja nefrona, što dovodi do gubitka sposobnosti bubrega da obavljaju svoju funkciju. Za proučavanje akutne renalne insuficijencije korišćen je veći broj različitih eksperimentainih modela pri čemu su uglavnom opisivane histopatološke promene u ovom organu. Naša ispitivanja su imala za cilj da se utvrdi funkcionalna sposobnost bubrega pasa u toku akutne renalne insuficijencije, izazvane visokim dozama gentamicina (80 mg/kg/24h), aplikovanim tokom 7 dana. U tom cilju su određivane fizičko-hemijske karakteristike mokraće, koncentracija relevantnih sastojaka u serumu i urinu kao i klirens endogenog kreatininina. Dobijeni rezultati ukazuju da se dozama gentamicina, dvadeset puta većim od terapijskih, već posle tri dana aplikacije izaziva ARI koja ima progresivan tok do kraja ogleda

Modulacija eksperimentalnog autoimunog encefalomijelitisa (EAE) DA pacova levamizolom

We investigated the influence of an antiparasitic drug, levamisole (2,3,5,6 - tetrahydro - 6- phenyl-imidazo (2,1 - b) thiazole -hydrochloride) with potent immunomodulatory properties on the course and development of experimental autoimmune encepha-lomyelitis (EAE). EAE was induced in female Dark Agouti (DA) rats aged two months by immunization with guinea pig spinal cord in complete Freunds adjuvant. Following immunization animals were subcutaneously treated every other day with 2.2 mg/kg levamisole. The course, development and characteristics of this autoimmune process were monitored as indirect indicators of immune system activity. Our results indicate that in EAE levamisole exerts immunosuppressive effects when administered every other day from the moment of immunization until the end of the disease. This application regime and dose postponed the onset of the first clinical signs, shortened the duration of the disease, abrogated the severity of clinical symptoms and accelerated the recovery of sick animals. In the period of induction and during EAE, levamisole also decreased the severity of changes in the cerebral perivascular spaces. In the peripheral blood of levamisole treated animals with induced EAE, a significant increase of CD4-CD8+ T cells was demonstrated. Furthermore, all rats with induced EAE had decreased numbers of CD4+CD8- T cells in their blood. These changes were in correlation with clinical signs of EAE.U ovom radu su prikazani rezultati ispitivanja anthelmintika levamizola (2,3,5,6 tetrahidro - 6 - fenil - imidazo (2,1 - b) tiazol hidrohlorida) sa snažnim imunomodulatornim svojstvima na tok i razvoj eksperimentalnog autoimunog encefalomijelitisa (EAE). EAE je indukovan imunizacijom ženki pacova soja DA (Dark Agouti) starih dva meseca pomoću homogenata kičmene moždine zamorčeta u kompletnom Freundovom adjuvansu. Posle imunizacije, životinje su tretirane subkutanim injekcijama levamizola (2.2 mg/kg) svaki drugi dan a praćeni su tok, razvoj i karakteristike ovog autoimunog oboljenja kao indirektni indikatori aktivnosti imunološkog sistema. Postignuti rezultati ukazuju dalevamizol ispoljava imunosupresivno delovanje u modelu EAE ako se aplikuje svaki drugi dan od momenta imunizacije do kraja bolesti. Primenjena doza i režim aplikacije odložili su momenat pojavljivanja prvih kliničkih simptoma, skratili trajanje bolesti, ublažili ispoljavanje simptoma i ubrzali oporavak bolesnih životinja. U periodu indukcije i tokom EAE-a levamizol je smanjio stepen promena u cerebralnim perivaskularnim prostorima. U ženskoj krvi ženki pacova sa indukovanim EAE i tretiranim levamizolom uočeno je značajno povećanje broja CD4-CD8+ T ćelija. Osim toga, u obe imunizovane grupe životinja zapaženo je smanjenje broja CD4+CD8- ćelija. Ove promene su bile u skladu sa kliničkom slikom bolesti

Improvement possibilities of the I-V characteristics of PIN photodiodes damaged by gamma irradiation

This paper presents the behavior of PIN photodiodes after combined gamma and neutron irradiation. Different types of PIN photodiodes have been exposed first to gamma and then to neutron irradiation. I-V characteristics (current dependence on voltage) of photodiodes have been measured after each of these irradiations. It has been noted that the photocurrent level after the neutron irradiation is higher than before it, which is not consistent with the current theories about the effects of neutron radiation on semiconductors. In order to explain this behavior of the photodiodes, the Monte Carlo simulation of photon transport through the material has been used. It is proposed that a possible cause for current enhancement are defects in semiconductor created by gamma irradiation and effects of neutron irradiation on these defects. The results can be explained by an intercentre transfer of charge between defects in close proximity to each other. The aim of this paper is to investigate the improvement possibilities of the I-V characteristics of PIN photodiodes, and photodetectors in general, damaged by gamma irradiation. [Projekat Ministarstva nauke Republike Srbije, br. 171007

Ispitivanje efekata različitih elektroterapijskih procedura u tretmanu ankilozirajućeg spondilitisa kod pasa

This paper presents the results of studies on the effects of suppression of chronic pain by currents with low (TENS), medium (Intf) and high (MT) frequencies, in dogs with ankylosing spondilytis. Prior to imaging diagnostics the dogs were clinically observed, trias was estimated, as well as habitus, neurological signs and degree of pain. After a 10 day treatment it was clear that all three treatments resulted in a significant decrease of pain at rest, during activity or during palpation. TENS currents have shown the highest degree of effect. All treated animals have shown improved motility after a few months of therapy. Despite the fact that all animals had an improved clinical picture none of the applied currents resulted in a complete loss of limping. Dogs treated with Intf currents displayed a decrease in muscular atrophy. Motility of the coxofemoural joint was most evident in the group treated with microwaves.U radu su prikazana ispitivanja supresije hroničnog bola pod uticajem struja niske (TENS), srednje (Intf) i visoke (MT) frekvence, kod pasa sa ankilozirajućim spondilitisom. Psi su pre rendgenskog snimanja opservirani, urađena im je procena trijasa, habitusa, a zatim neurološki pregled i određivanje stepena bola. Nakon desetodnevnog tretmana, uočeno je da su sva tri postupka dovela do visoko značajnog smanjenja bola u toku mirovanja ili aktivnosti i pri palpaciji, pri čemu su se isticale TENS struje u odnosu na Intf struje i mikrotalase. Kod tretiranih jedinki je zapažena izraženija motorna aktivnost, a nekoliko meseci od početka lečenja, uz određene kineziterapijske vežbe, psi su bili sa bitno redukovanim simptomima oboljenja. Iako je u svakoj grupi ispitivanih jedinki došlo do poboljš anja stanja, ni jedan terapijski postupak nije doveo do potpunog gubitka hromosti. Jedino je u grupi pacijenata tretiranih sa Intf strujama, došlo do značajnog smanjenja stepena mišićne atrofije, a pokretljivost koksofemoralnih zglobova je bila najizraženija kod pacijenata tretiranih mikrotalasima