Comfortable urban environment as the determining factor of the development of megapolises

The paper examines the impact of the development of large urban agglomerations on the welfare and quality of life. The attractiveness of megacities from the standpoint of increasing urbanization, the concentration of investment resources and the accumulation of industrial, financial and business centers in them today do not unequivocally affect the well-being and comfort of human living. Converting the wealth accumulated by the megalopolis into an attractive living environment becomes an elusive problem that requires research into the main factors and parameters of comfortable urban living. The method for evaluating megacities presented in the paper on the basis of the comfort parameters of the urban environment that we form allows us to identify areas of the necessary improvement, or the conversion of wealth into the quality of life

Lexical-Semantic Analysis of English Phraseological Units with Phytonym Component

This article devoted to the lexical-semantic analysis of English phraseological units with phytonym component. The subject of this paper is a lexical and semantic analysis and characteristics of such phraseological units. Special attention is given to lexical and semantic features of phytonyms functioning. The use of the term “phytonym” is define

Functional constipation in children

Constipation is one of the most common nosologies that a pediatric gastroenterologist deals with during outpatient visits. In the vast majority of children with constipation the problem is functional in nature. According to studies published in the Russian Federation, the frequency of constipation in children accounts for about 25–30%. The joint clinical guidelines of the European and North American Societies of Pediatric Gastroenterologists, Hepatologists and Nutritionists for the management of children with functional constipation were published in 2014. The national guidelines for the diagnosis and treatment of functional constipation are based on these guidelines. According to the clinical guidelines, the 2006 Rome III criteria should be used to establish the diagnosis of functional constipation in children. In May 2016, the Rome IV criteria that provide separate diagnostic criteria for infants and children under 4 years of age and children over 4 years and teenagers were adopted. A group of children with symptoms of constipation, who have already had toilet skills at the time of diagnosis, was identified among infants and children under 4 years of age. The presence of anxiety symptoms or refractory constipation (constipation that does not resolve within 3 months while taking adequate therapy) is considered an indication for use of additional examination methods, including instrumental ones. The manifestation of constipation is often associated with a change in eating habits - the period of introduction of complementary feeding in infants or the beginning of going to a day-care centre, inadequate fluid intake. The onset of constipation often coincides with the period of the development of hygiene skills (potty training). The voluntary stool retention by a child who is trying to avoid painful defecation experiences is the main mechanism for the development of constipation. The aim of functional constipation treatment is to soften the stools, which facilitates painless defecation and ensure that there is an urge to defecate. Clinical examples of the treatment of patients with functional constipation and chronic colonic stasis, functional constipation and encopresis are provided. The outcome of the treatment of functional constipation is to ensure painless defecation and the development of a stable defecation reflex. The drug therapy for functional constipation is based on the use of laxatives. Dietary advice and behavioral therapy also play an important role

Approaches to prevention of antibiotic-associated diarrhea in children

The incidence of antibiotic-associated diarrhea, according to various authors, ranges from 5 to 39% and depends on the patient’s age and other contributing factors. Antibiotic-associated diarrhea can be caused by any antibiotic, regardless of dosage form or route of administration. In the pediatric population, the prevalence of antibiotic-associated diarrhea ranges from 6 to 70%. An urgent problem is the development of this disease against the background of a course of H. pylori eradication therapy, which significantly complicates tolerance and adherence to therapy. This article presents current data on the pathogenesis and risk factors of antibiotic-associated diarrhea in children. The clinical picture ranges from idiopathic enteritis to antibiotic-associated diarrhea caused by Cl. difficile - pseudomembranous colitis.The main principle of antibiotic-associated diarrhea treatment is cancellation of the antibacterial medicine that caused the diarrhea, or reducing its dose (if the course of the disease allows it). In complex treatment sorbents are used, correction of water-electrolyte balance is carried out. The use of probiotics seems quite logical for the treatment and prevention of antibiotic-associated diarrhea in terms of the pathogenesis of this condition. To correct dysbiosis, drugs are used to maintain and restore the quantitative and qualitative composition of the intestinal microbiota.Taking into account modern recommendations the main groups of drugs (probiotics, prebiotics, synbiotics) used for correction of intestinal microbiocenosis are presented. The mechanism of action of probiotics and mechanisms of their effect on intestinal microflora are considered. The basic requirements for bacterial strains that are part of the probiotic drugs are presented.The results of various randomized clinical trials and meta-analyses confirming the necessity of including probiotic complexes in antibiotic-associated diarrhea treatment regimens are presented from an evidence-based medicine perspective. The clinical effects of strains of Lactobacillusspp., Bifidobacterium spp.,Streptococcusspp. and Lactococcusspp. on the digestive tract microbiota are considered. The role of a synbiotic containing 9 probiotic strains of 4.5 * 109 CFU in one capsule and the prebiotic component fructooligosac-charides in the prevention of antibiotic-associated diarrhea in children is discussed separately. The results of microbiological studies confirmed the presence of microorganisms of genera Bifidobacterium, Lactobacillus, Streptococcus in the product, and the content of bacteria in one dose of the product was not less than 2 x 1010 CFU

English Nouns’ Valency in Terms of Phraseology

This article deals with the analysis of the noun used in the English phraseology as it has the highest phraseological activity. The subject of special attention is a study of phraseological units with a phytonym component. The group of phraseological units with a phytonym component is the most frequently used one. Some phytonyms demonstrate unusual cultural connotations typical to this languag

New realities of chickenpox

Introduction. The causative agent of chickenpox is ubiquitous. In children, especially with a burdened premorbid background, there is a high incidence of severe forms and complications.Aim. To study the course of chickenpox in children in modern conditions.Material and methods. 58 pediatricians (group 1), 42 parents of children aged 0 to 3 years (group 2) and 43 parents of children aged 3 to 6 years (group 3) were surveyed.Results and discussion. In the 1st group, 224 children (73.68%) had a long period of rashes, 57 children (18.75%) had a mild and not long period. At the age of 16, unvaccinated children first fell ill with chickenpox. In 23 patients (7.57%), there were obvious clinical manifestations of chickenpox with a pronounced and prolonged intoxication syndrome. In 67.43%, a positive Mantoux test was recorded with an increase in papule and corolla of hyperemia in dynamics. The development of complications significantly more often (p = 0.0429) was recorded in the group of children with aggravated premorbid background. All pediatricians are positive about vaccination. In the 2nd group, out of 37.5% of parents who are against vaccination, 16.67% believe that the vaccine does not always have a positive effect on the health of the child. The ineffectiveness of vaccines is recognized by 45.83% of respondents. 40.47% of children have not been vaccinated and they do not have vaccination certificates. In the 3rd group, 32.56% of children were ill with chickenpox, of which 79.07% had a mild form of the disease. 67.44% have a positive attitude towards vaccination against chickenpox. The coverage of all vaccines according to the National calendar was 100%.Conclusion. Chickenpox is a serious unsafe infectious disease that requires specific prophylaxis

The research of abnormal toxicity and local irritant effect in the Draize test of the drug furacilin, concentrate for the preparation of a solution for local and externaluse

The research of abnormal toxicity and locally irritating effect of the drug Furacilin, concentrate for the preparation of a solution for local and external use in comparison with the drug Furacilin, tablets for the preparation of the solution, was carried ou

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Optical fibers are widely used in bioimaging systems as flexible endoscopes capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique which allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), paving the way for combing MRI and optical bioimaging. Our approach is based on Layer-by-Layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI that opens novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.Comment: 11 pages, 6 figure