Assessing mechanical integrity of spinal fusion by in situ endochondral osteoinduction in the murine model

<p>Abstract</p> <p>Background</p> <p>Historically, radiographs, micro-computed tomography (micro-CT) exams, palpation and histology have been used to assess fusions in a mouse spine. The objective of this study was to develop a faster, cheaper, reproducible test to directly quantify the mechanical integrity of spinal fusions in mice.</p> <p>Methods</p> <p>Fusions were induced in ten mice spine using a previously described technique of in situ endochondral ossification, harvested with soft tissue, and cast in radiolucent alginate material for handling. Using a validated software package and a customized mechanical apparatus that flexed and extended the spinal column, the amount of intervertebral motion between adjacent vertebral discs was determined with static flexed and extended lateral spine radiographs. Micro-CT images of the same were also blindly reviewed for fusion.</p> <p>Results</p> <p>Mean intervertebral motion between control, non-fused, spinal vertebral discs was 6.1 ± 0.2° during spine flexion/extension. In fusion samples, adjacent vertebrae with less than 3.5° intervertebral motion had fusions documented by micro-CT inspection.</p> <p>Conclusions</p> <p>Measuring the amount of intervertebral rotation between vertebrae during spine flexion/extension is a relatively simple, cheap (<$100), clinically relevant, and fast test for assessing the mechanical success of spinal fusion in mice that compared favorably to the standard, micro-CT.</p

An Algebraic Attack on Rank Metric Code-Based Cryptosystems

International audienceThe Rank metric decoding problem is the main problem considered in cryptography based on codes in the rank metric. Very efficient schemes based on this problem or quasi-cyclic versions of it have been proposed recently, such as those in the submissions ROLLO and RQC currently at the second round of the NIST Post-Quantum Cryptography Standardization Process. While combinatorial attacks on this problem have been extensively studied and seem now well understood, the situation is not as satisfactory for algebraic attacks, for which previous work essentially suggested that they were ineffective for cryptographic parameters. In this paper, starting from Ourivski and Johansson's algebraic modelling of the problem into a system of polynomial equations, we show how to augment this system with easily computed equations so that the augmented system is solved much faster via Groebner bases. This happens because the augmented system has solving degree $r$, $r+1$ or $r+2$ depending on the parameters, where $r$ is the rank weight, which we show by extending results from Verbel et al. (PQCrypto 2019) on systems arising from the MinRank problem; with target rank $r$, Verbel et al. lower the solving degree to $r+2$, and even less for some favorable instances that they call superdetermined. We give complexity bounds for this approach as well as practical timings of an implementation using Magma. This improves upon the previously known complexity estimates for both Groebner basis and (non-quantum) combinatorial approaches, and for example leads to an attack in 200 bits on ROLLO-I-256 whose claimed security was 256 bits

Factors Affecting Auditory Performance of Postlinguistically Deaf Adults Using Cochlear Implants:An Update with 2251 Patients

<p>Objective: To update a 15-year-old study of 800 postlinguistically deaf adult patients showing how duration of severe to profound hearing loss, age at cochlear implantation (CI), age at onset of severe to profound hearing loss, etiology and CI experience affected CI outcome. Study Design: Retrospective multicenter study. Methods: Data from 2251 adult patients implanted since 2003 in 15 international centers were collected and speech scores in quiet were converted to percentile ranks to remove differences between centers. Results: The negative effect of long duration of severe to profound hearing loss was less important in the new data than in 1996; the effects of age at CI and age at onset of severe to profound hearing loss were delayed until older ages; etiology had a smaller effect, and the effect of CI experience was greater with a steeper learning curve. Patients with longer durations of severe to profound hearing loss were less likely to improve with CI experience than patients with shorter duration of severe to profound hearing loss. Conclusions: The factors that were relevant in 1996 were still relevant in 2011, although their relative importance had changed. Relaxed patient selection criteria, improved clinical management of hearing loss, modifications of surgical practice, and improved devices may explain the differences. Copyright (c) 2012 S. Karger AG, Basel</p>