Innovation and external knowledge sources in knowledge intensive business services (KIBS): evidence from de-industrialized UK regions

This paper explores the effect of external knowledge sources and the uneven geography on innovation activity in small Knowledge Intensive Business Services (KIBS). It draws on results from a survey of 342 small and medium (SME) KIBS located in the UK’s North East and West Midlands, both de-industrialised regions. It is shown that innovation is supported by knowledge gained from frequent interaction with customers both regional and UK based as well as international. More frequent interaction with local business networks, informal contacts and national licensing arrangements also enhances innovativeness. Various industry-specific business networks and regional government agencies act as important sources of knowledge and networking and these are more important for KIBS located in the North East. The results indicate that more frequent collaboration with regional universities and regional public sector organisations does not benefit KIBS from either region. Also, while we acknowledge a positive effect of R&D on KIBS innovativeness we argue that its effect is less important compared to regional and extra regional knowledge sources

The effect of external knowledge sources and their geography on innovation in Knowledge Intensive Business Services (KIBS) SMEs; some Implications for de-industrialized regions in the UK

The paper explores the effect of external knowledge sources and their geography on innovation activity in small Knowledge Intensive Business Services (KIBS). It draws on results from a survey conducted in 2010 of 342 small and medium (SME) KIBS in the UK’s, North East and West Midlands. It is shown that innovation is supported by knowledge gained from frequent interaction with regional and UK customers as well as more frequent interaction with local business networks, including informal contacts as well as national licensing arrangements, regional and UK commercial networks and UK public and professional infrastructure. Innovation capability is also enhanced by internationalisation through both traded and untraded relationships. Various industry-specific business networks and regional government agencies also act as important sources of knowledge and networking in de-industrialised regions. No support is found for benefits arising from the clustering of firms in similar line of business or with regional universities or public sector organisations. Also, while we acknowledge positive effect of R&D on KIBS innovativeness we argue that its' effect is much less important compared to regional and extra regional knowledge source

Regional environments and sector developments: the biotech sector in Oxfordshire

This paper explores the interdependence between national policy, the local characteristics of the UK’s biotechnology sectoral system of innovation and the growth of Oxfordshire’s biotech sector. It considers on the one hand the county’s research capacity and on the other its innovation performance. The latter is captured by a series of indicators from a recently completed study of the sector, recording the sector’s evolution both in the number of firms and their employment size, their status (independent, merged/acquired), product group and contribution to local employment and wealth creation. It considers the implications of the relative weaknesses in the system of innovation in this sector which relate to an underperformance of its firms in relation to the strength of the science base

Examining Process in Developing Products/Services in UK University Spin-off Context

Interaction or knowledge transfer activities between universities and industry have been observed and widely studied. One of the important categories of linkages and technology transfer is academic entrepreneurship, which includes commercial exploitation of technologies by academic entrepreneurs through setting up a company (Perkman, and Walsh, 2007). With unique and hybrid characteristics, university spin-offs are regarded as an economically compelling subcategory of high-tech start-up firms (Shane, 2005).The study of mechanisms in transferring technology that led to the commercial exploitation of university research through firm creation dates from the late 1960s (Landstr̈om, 2005). However, the product and service innovations of university spin-offs, the conversion of university research into a product and/or a service, as well as the creation of a product or service responding to the market demands (Shane, 2005) remain under-studied. There are gaps in knowledge about the transformation and transfer from academic research to the development of a market-driven product/service (Barr et al., 2009) and in how the product/service development process functions within the university spin-off context (Shane, 2005). The data collected from in-depth interviews of 20 university spin-offs’ founders are used to explore the processes by which products/services within the university spin-off environment are created and to answer the following research question: How is the process of product/service development of USOs organised? The findings show that the development processes, whether for products, services or software, are different from each other, one of the shared characteristics is that customers’ requirements take primary and centre stage in the development process. Additionally, the development process is non-linear; a number of iterations occur during the process. This study has filled a gap in the academic entrepreneurship literature by shedding light on the process by which academic research is transferred and commercialised through the mechanism of products/services development. It also gives grounds for considering the notion that university spin-offs seem to bear a resemblance to the practices of small firms in product/service innovation, i.e. informal and non-linear products/services development processes

Innovation capacity in the healthcare sector and historical anchors: examples from the UK, Switzerland and the US

Innovation is an integral part of economic development in developed economies. In the post 2008 period, a key policy agenda is that of sustainable development, which calls for innovation in all aspects of value-chains. In this paper, we focus on innovation from the biotech—pharma perspective to see whether or not this will lead to a sustainable future for the regions where there are clusters of firms in this sector. We examine data from a recently completed European Union study of innovation in the Healthcare sector from the UK and Switzerland, countries with an historical base in pharma, to understand how innovation pathways vary at the regional level in the broader life sciences, which incorporate biotech and more. Innovation in the healthcare sector in two regions, Oxfordshire in the UK and Zurich in Switzerland are compared. We contextualize our discussion by drawing on studies that focus on the sector in the US, specifically Boston. The analytical framework comprises three elements: innovation systems and national and regional economic development theories are the first two, followed by approaches which consider organizational or institutional activity. This framework is used to help explain and understand the complexity of how innovation is organized at the sub-national level. The overall context is that it is increasing becoming a condition for government financing of research that it has more immediate application in industry or have the possibility of commercialisation (e.g., translational research)

Academic entrepreneurship: spin-offs in Sweden and the UK

Discussions of academic entrepreneurship often focus on efforts to commercialize inventions appropriated within the intellectual property (IP) system. However, studies in the U.S. have shown that a substantial amount of entrepreneurship happens outside of the formal IP system. In the UK each university sets its own rules on ownership of IP. In a few European countries, like Sweden, an inventor ownership model is dominating. There is a lack of studies of European academic entrepreneurship outside of the formal IP system; and accordingly there have been few possibilities to analyze the effects of different institutional set ups. To help fill this gap, this chapter analyses how different institutional settings affect academic entrepreneurship in Europe. By analyzing both patents and spinoffs (from Oxford University, UK and Chalmers University, Sweden) we will shed light on two processes for commercialization of university research. We empirically investigate university technology transfer at two different universities in two countries with a different inventor ownership regulation

Proof of the Hyperplane Zeros Conjecture of Lagarias and Wang

We prove that a real analytic subset of a torus group that is contained in its image under an expanding endomorphism is a finite union of translates of closed subgroups. This confirms the hyperplane zeros conjecture of Lagarias and Wang for real analytic varieties. Our proof uses real analytic geometry, topological dynamics and Fourier analysis.Comment: 25 page

Examining the Connections within the Startup Ecosystem: A Case Study of St. Louis

This paper documents the resurgence of entrepreneurial activity in St. Louis by reporting on the collaboration and local learning within the startup community. This activity is happening both between entrepreneurs and between organizations that provide support, such as mentoring and funding, to entrepreneurs. As these connections deepen, the strength of the entrepreneurial ecosystem grows. Another finding from the research is that activity-based events, where entrepreneurs have the chance to use and practice the skills needed to grow their businesses, are most useful. St. Louis provides a multitude of these activities, such as Startup Weekend, 1 Million Cups, Code Until Dawn, StartLouis, and GlobalHack. Some of these are St. Louis specific, but others have nationwide or global operations, providing important implications for other cities

Introduced plants as novel Anthropocene habitats for insects

Major environmental changes in the history of life on Earth have given rise to novel habitats, which gradually accumulate species. Human‐induced change is no exception, yet the rules governing species accumulation in anthropogenic habitats are not fully developed. Here we propose that nonnative plants introduced to Great Britain may function as analogues of novel anthropogenic habitats for insects and mites, analysing a combination of local‐scale experimental plot data and geographic‐scale data contained within the Great Britain Database of Insects and their Food Plants. We find that novel plant habitats accumulate the greatest diversity of insect taxa when they are widespread and show some resemblance to plant habitats which have been present historically (based on the relatedness between native and nonnative plant species), with insect generalists colonizing from a wider range of sources. Despite reduced per‐plant diversity, nonnative plants can support distinctive insect communities, sometimes including insect taxa that are otherwise rare or absent. Thus, novel plant habitats may contribute to, and potentially maintain, broader‐scale (assemblage) diversity in regions that contain mixtures of long‐standing and novel plant habitats

Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients

Background Parkin related Parkinson's disease (PD) is differentiated from idiopathic PD by absent or sparse Lewy bodies, and preserved olfaction. The significance of single Parkin mutations in the pathogenesis of PD is debated. Objectives To assess olfaction results according to Parkin mutation status. To compare the prevalence of Parkin single heterozygous mutations in patients diagnosed with PD to the rate in healthy controls in order to establish whether these single mutations could be a risk factor for developing PD. Methods Parkin gene mutation testing was performed in young onset PD (diagnosed <50 years old) to identify three groups: Parkin homozygous or compound heterozygote mutation carriers, Parkin single heterozygote mutation carriers, and non-carriers of Parkin mutations. Olfaction was tested using the 40-item British version of the University of Pennsylvania smell identification test (UPSIT). Results Of 344 young onset PD cases tested, 8 (2.3%) were Parkin compound heterozygotes and 13 (3.8%) were Parkin single heterozygotes. Olfaction results were available in 282 cases (eight compound heterozygotes, nine single heterozygotes, and 265 non-carriers). In Parkin compound heterozygotes, the median UPSIT score was 33, interquartile range (IQR) 28.5–36.5, which was significantly better than in single Parkin heterozygotes (median 19, IQR 18–28) and non-carriers (median score 22, IQR 16–28) (ANOVA P < 0.001). These differences persisted after adjusting for age, disease duration, gender, and smoking (P < 0.001). There was no significant difference in UPSIT scores between single heterozygotes and non-carriers (P = 0.90). Conclusions Patients with Parkin compound heterozygous mutations have relatively preserved olfaction compared to Parkin single heterozygotes and non-carriers. The prevalence of Parkin single heterozygosity is similar to the 3.7% rate reported in healthy controls