Ironing out the details: Untangling dietary iron and genetic background in diabetes

The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health. Genetic variation between individuals confers differences in metabolism, which directly impacts response to diet. Most studies attempting to identify genetic risk factors in disease fail to incorporate dietary components, and thus are ill-equipped to capture the breadth of the genome’s impact on metabolism. Understanding how genetic background interacts with nutrients holds the key to predicting and preventing metabolic diseases through the implementation of personalized nutrition. Dysregulation of iron homeostasis is associated with type-II diabetes, but the link between dietary iron and metabolic dysfunction is poorly defined. High iron burden in adipose tissue induces insulin resistance, but the mechanisms underlying adipose iron accumulation remain unknown. Hepcidin controls dietary iron absorption and distribution in metabolic tissues, but it is unknown whether genetic variation influencing hepcidin expression modifies susceptibility to dietary iron-induced insulin resistance. This review highlights discoveries concerning the axis of iron homeostasis and adipose function and suggests that genetic variation underlying dietary iron metabolism is an understudied component of metabolic disease

Virginia\u27s Money Follows the Person Demonstration

Educational Objectives 1. Describe Virginia\u27s Money Follows the Person Demonstration project, including the new services available to individuals through Virginia\u27s Medicaid-funded home and community-based waiver program. 2. Explain how Virginia\u27s Money Follows the Person Demonstration project, being administered by the Virginia Department of Medical Assistance Services (DMAS), would assist an individual in transitioning from a long-term care facility to the community. 3. Illustrate how someone might experience the MFP processes from pre-transition through post-transition

Tarski monoids: Matui's spatial realization theorem

We introduce a class of inverse monoids, called Tarski monoids, that can be regarded as non-commutative generalizations of the unique countable, atomless Boolean algebra. These inverse monoids are related to a class of etale topological groupoids under a non-commutative generalization of classical Stone duality and, significantly, they arise naturally in the theory of dynamical systems as developed by Matui. We are thereby able to reinterpret a theorem of Matui on a class of \'etale groupoids as an equivalent theorem about a class of Tarski monoids: two simple Tarski monoids are isomorphic if and only if their groups of units are isomorphic. The inverse monoids in question may also be viewed as countably infinite generalizations of finite symmetric inverse monoids. Their groups of units therefore generalize the finite symmetric groups and include amongst their number the classical Thompson groups.Comment: arXiv admin note: text overlap with arXiv:1407.147

The distribution of chlorophyll in the western Indian Ocean during the northeast monsoon period, February 13-July 16, 1965

This report contains the observations of phytoplankton pigment characteristics made during ATLANTIS II Cruise No. 15 in the western Indian Ocean and its reaches during the period of February 13 through July 16, 1965. As pointed out in a previous report for this region (Laird et al., 1964), the observations should by no means be considered synoptic since short-term variation will occur in biological measurements. The value of the present observations is greatly enhanced by the fact that they repeat and extend the previous data from ATLANTIS II Cruise No. 8 for the area, but are taken at the opposite period of the year for all regions. The data permit only a first approximation of the relative fertility in the area, yet the seasonal contrast becomes an important consideration in the analysis and interpretation of the data. It is believed that this represents the first such large-scale survey for Indian Ocean waters.The National Science Foundation under Grant NSF-GP 82

Space capsule ejection assembly Patent

Describing assembly for opening stabilizing and decelerating flaps of flight capsules used in space researc

Modified spiral wound retaining ring

A spiral wound retaining ring with angled ends is described. The ring is crimped at the same angle as the ring ends to maintain a constant thickness dimension. The angling of the ends of the ring and crimp allow the ends to be positioned closer together while maintaining enough clearance to enable insertion and removal of the ring. By reducing the separation distance between the ends a stronger ring results since the double layer area of the ring is maximized

An Innovative Collective Parent Engagement Model for Families and Neighborhoods in Arrival Cities

Arrival Cities are special urban places. Amid the largest migration in human history, they provide homes for large numbers of mobile, low-income, immigrant families. These families need new human service and child welfare service models. Collective parent engagement (CPE) is one such model. CPE is designed to build on the strengths and meet the needs of immigrant families living in Arrival City neighborhoods. In contrast to interventions focused on individual parents, this CPE model mobilizes groups of parents; and with a dual agenda. CPE develops much-needed “anchoring supports” for mobile, vulnerable families, at the same time that it positions local organizations to become welcoming, supportive, and resource-providing social settings for families on the move. Enhanced professional preparation and training programs, together with enhanced organizational and policy development, are needed to realize this important agenda

The Double-Edged Sword of Industry Collaboration: Evidence from Engineering Academics in the UK

This paper studies the impact of university-industry collaboration on academic research output. We report findings from a unique longitudinal dataset on all the researchers in all the engineering departments of 40 major universities in the UK for the last 20 years. We introduce a new measure of industry collaboration based on the fraction of research grants that include industry partners. Our results show that productivity increases with the intensity of industry collaboration, but only up to a certain point. Above a certain threshold, research productivity declines. Our results are robust to several econometric estimation methods, measures of research output, and for various subsamples of academics