Global Rules for Global Health: Why We Need An Independent, Impartial WHO

Over the past few years the World Health Organization (WHO) has been undergoing a significant reform process. The immediate trigger was a budget crisis in 2010 that spurred massive lay-offs at the global agency. But at a more fundamental level, deeper systematic changes in global health governance have made reform imperative. While WHO reform draws relatively little attention outside diplomatic circles in Geneva, at stake are critical issues that will impact public health everywhere. This article’s key messages are: Recent outbreaks of MERS highlight the need for a global response to infectious disease The WHO has had a crucial role in developing rapid information sharing on new infectious threats and fair arrangements for access to drugs and vaccines and to research and development The WHO is the only international agency that can broker such global rules but is badly underfunded to perform this core function The MERS outbreaks offer an opportunity to reform WHO financing

Wealthy Countries Should Share Vaccine Doses Before It Is Too Late: The Greater Good Depends on Ending the Pandemic Everywhere

The world is on the brink of failing a critical test, which is whether the international community is willing or able to end a global pandemic without leaving anyone behind. Wealthy countries have bought up vast vaccine supplies, leaving poorer ones with extreme scarcity. An international initiative known as the COVID-19 Global Vaccine Access Facility (COVAX) aims to distribute vaccines widely and equitably, but is not only short of funds. Even if it reaches its 2021 target, COVAX will reach only a small portion of lower-income countries’ populations this year. Along with moral demands of equitable global distribution, wealthy countries have deep humanitarian reasons, as well as economic, geostrategic and, critically, health reasons for equitable distribution, as without global protection, no country is safe from COVID-19. Wealthy countries should vastly expand their efforts beyond present COVAX support to enable far more equitable global distribution. First, they should reallocate a portion of the doses they have secured for themselves – beyond excess doses to include those that they were going to use for their own populations – particularly as the United States and Europe get their own surges under control, during which time they are also vaccinating vulnerable populations. They should accept slower herd immunity for themselves to enable the world to move at a more equal pace in protecting national populations. Second, they should commit at least 2% of COVID-19 spending to response and recovery in low- and middle-income countries, amounting to $260 billion to-date, with more to follow. This would cover funding for accelerating distribution of vaccines, therapies, and diagnostics globally and provide vital humanitarian and social protection funds. Third, wealthy countries should ensure equitable distribution domestically and that vulnerable populations are quickly protected globally, including internally displaced people, asylum seekers, refugees, and stateless people. And fourth, they should work with the World Health Organization and other countries to spearhead and fund a global facility, with binding rules, for the equitable distribution of vaccines, therapeutics, and diagnostics

Josephson surface plasmons in spatially confined cuprate superconductors

In this work, we generalize the theory of localized surface plasmons to the case of high-Tc cuprate superconductors, spatially confined in the form of small spherical particles. At variance from ordinary metals, cuprate superconductors are characterized by a low-energy bulk excitation known as the Josephson plasma wave (JPW), arising from interlayer tunneling of the condensate along the c-axis. The effect of the JPW is revealed in a characteristic spectrum of surface excitations, which we call Josephson surface plasmons. Our results, which apply to any material with a strongly anisotropic electromagnetic response, are worked out in detail for the case of multilayered superconductors supporting both low-frequency (acoustic) and transverse-optical JPW. Spatial confinement of the Josephson plasma waves may represent a new degree of freedom to engineer their frequencies and to explore the link between interlayer tunnelling and high-Tc superconductivity

CACNA1C: Association with pychiatric disorders, behavior, and neurogenesis

Large-scale genome-wide association studies have consistently shown that genetic variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit alpha1C, increases risk for psychiatric disorders. CACNA1C encodes the Cav1.2 subunit of voltage-gated calcium channels, which themselves have been functionally implicated in a broad spectrum of neuropsychiatric syndromes. Research has concentrated on uncovering the underlying biological mechanisms that could be responsible for this increased risk. This review presents an overview of recent findings regarding Cacna1c variation in animal models, particularly focusing on behavioral phenotypes associated with neurodevelopmental disorders such as cognition, anxiety and depressive phenotypes, and fear conditioning. The impact of reduced gene dosage of Cacna1c on adult hippocampal neurogenesis is also assessed, including new data from a novel Cacna1c+/− rat model

Bullying and school disruption assessment: studies with Portuguese adolescent students

Problem Statement: The question of bullying and school disruptive behavior has emerged as a powerful issue in Portuguese educational context. The lack of evaluation instruments, with studied psychometric characteristics, has constituted a problem. Purpose of Study: School disruption and bullying assessment, in Portuguese adolescents, was the focus of this research. Research Methods: The psychometric qualities — internal consistency and the external validity — were analyzed in different scales. Findings: The analyses carried out confirm the scales as reliable and valid instruments. Conclusions: These instruments may be a useful avenue for teachers, psychologists and other education professionals

Optimization of a 96-Well Electroporation Assay for Postnatal Rat CNS Neurons Suitable for Cost–Effective Medium-Throughput Screening of Genes that Promote Neurite Outgrowth

Following an injury, central nervous system (CNS) neurons show a very limited regenerative response which results in their failure to successfully form functional connections with their original target. This is due in part to the reduced intrinsic growth state of CNS neurons, which is characterized by their failure to express key regeneration-associated genes (RAGs) and by the presence of growth inhibitory molecules in CNS environment that form a molecular and physical barrier to regeneration. Here we have optimized a 96-well electroporation and neurite outgrowth assay for postnatal rat cerebellar granule neurons (CGNs) cultured upon an inhibitory cellular substrate expressing myelin-associated glycoprotein or a mixture of growth inhibitory chondroitin sulfate proteoglycans. Optimal electroporation parameters resulted in 28% transfection efficiency and 51% viability for postnatal rat CGNs. The neurite outgrowth of transduced neurons was quantitatively measured using a semi-automated image capture and analysis system. The neurite outgrowth was significantly reduced by the inhibitory substrates which we demonstrated could be partially reversed using a Rho Kinase inhibitor. We are now using this assay to screen large sets of RAGs for their ability to increase neurite outgrowth on a variety of growth inhibitory and permissive substrates