A Scopus-Based Bibliometric Review of Dental Research Productivity of Universities in North East of England: Policy Implications

Introduction: To evaluate the dental research productivity of the universities in the North East of England (NEE). Methods: We collected the bibliometric data of the dental publications of the five NEE universities from SCOPUS. Collected data were analysed using the Microsoft Excel 2021 software. Results: Dentistry was the health science subject area with the lowest volume of research productivity in two-fifth of the NEE universities. The NEE universities contributed <4% of the total dental research publications in the UK. Newcastle University was the NEE university with the highest volume of dental research productivity. The level of inter-institutional dental research collaborations among the NEE universities was very low. The USA-based institutions were the most productive foreign institutions collaborating with NEE universities. The study identified the five most published dental researchers at the NEE universities. Each of the NEE universities had at least 15.8% of its total dental research publications in the British Dental Journal. Conclusion: The findings obtained in this study gives a reflection of dental research productivity of NEE universities. There is a need to strengthen dental research capacity of universities in the NEE

Factors influencing cervical cancer screening practice among female health workers in Nigeria: A systematic review

BACKGROUND: Cervical cancer is the most prevalent gynaecologic cancer in Nigeria. Despite being largely preventable through screening, cervical cancer is the second leading cause of cancer morbidity and mortality in Nigeria. To reduce the burden of cervical cancer in Nigeria, female health workers (FHWs) are expected to play an influential role in leading screening uptake and promoting access to cervical cancer education and screening. AIM: The aim of this systematic review is to assess the factors influencing cervical cancer screening (CCS) practice among FHWs in Nigeria. METHODS: We conducted a systematic literature search across six (6) electronic databases namely MEDLINE, Embase, Scopus, African Index Medicus, CINAHL, and Web of Science between May 2020 and October 2020. Reference list and grey literature search were conducted to complement database search. Four reviewers screened 3171 citations against the inclusion criteria and critically appraised the quality of eligible studies. Narrative synthesis was used in summarising data from included studies. RESULTS: Overall, 15 studies met the inclusion criteria and were all quantitative cross‐sectional studies. Included studies sampled a total of 3392 FHWs in Nigeria. FHWs had a high level of knowledge and positive attitude towards CCS. However, CCS uptake was poor. Predominant barriers to CCS uptake were the cost of screening, fear of positive results, lack of test awareness, reluctance to screen, low‐risk perception, and lack of time. In contrast, being married, increasing age, awareness of screening methods, and physician recommendation were the most documented facilitators. CONCLUSION: This study revealed that a complex interplay of socioeconomic, structural, and individual factors influences CCS among FHWs in Nigeria. Therefore, implementing holistic interventions targeting both health system factors such as cost of screening and infrastructure and individual factors such as low‐risk perception and fear of positive result affecting FHWs in Nigeria is critical to reducing the burden of cervical cancer

A Primary Qualitative Study Exploring Adult BAME Individuals\u27 Experiences Regarding Physical Activity from the North-East of England During the COVID-19 Pandemic

Researchers have found that people from BAME communities have worse health outcomes from many health interventions and face health disparities. BAME individuals experience health inequities and lower health intervention results. The experiences of adult Teesside-based BAME individuals\u27 regarding physical activity (PA) during the COVID-19 pandemic were mapped onto the capability, opportunity, and motivation model of behaviour (COM-B). Twelve adult BAME participants were interviewed using semi-structured interviews that lasted 40 to 60 minutes and captured participant perceptions of how their PA and perceptions related to living a healthy PA lifestyle during the pandemic between April and August 2022 via Microsoft Teams. Using thematic analysis, 10 themes were generated, but only three themes were discussed. These include knowledge and awareness of the PA lifestyle, participants\u27 perceptions of the opportunities to improve the PA lifestyle choice of adult BAME, and the change in perceptions of PA due to COVID-19 lockdown. While literature has explored the COM-B model, there have been generalised findings that are not specific to adult BAME individuals\u27 lived PA experiences. The COVID-19 pandemic presents an opportunity to understand the shift in adult BAME perceptions and experiences during the coronavirus pandemic, therefore calling for the urgent need to modify both models in order to combat the high mortality rates of adult BAME individuals related to sedentary lifestyle diseases. This indicates that there is a critical requirement for the COMB model in order to implement policies. Nevertheless, limited PA studies have used lifestyle behaviour models to enhance behavioural modification

Tackling the Complexities of the Obesity Pandemic Among the BAME Population in the UK Through Identification of the Social Determinants of Mental Health and Wellbeing: A Narrative Review

Obesity\u27s multifaceted causes give rise to a complex and diverse range of health associated morbidities and comorbidities, including diabetes, hypertension, and cardiovascular disease, particularly among British Asian and Minority Ethnic (BAME) populations within in the UK. As found within the recent COVID-19 pandemic these can have wider reaching implications including increased risk of mortality within this population group. Understanding the potential social determinants of the causes of obesity is essential if effective strategies are to be developed to tackle this. A comprehensive search of the CINAHL, ASSIA and Web of Science databases was undertaken with 148 papers identified. Through application of inclusion and exclusion criteria two papers were included within this review. Inductive content analysis was undertaken, through which four conceptual categories were identified: impact of social culture, the limitless consequences of empowerment, the power of knowledge, and external elements. Social determinants such as culture, perception, family, and mental health have been found to impact significantly on the ability of many individuals within the BAME population to effectively engage with obesity and weight loss strategies. A greater understanding of these social determinants is needed if future strategies aimed at addressing the obesity pandemic within this population is to be effective

Exploring the barriers and facilitators to making healthy physical activity lifestyle choices among UK BAME adults during covid-19 pandemic: A study protocol

Past research has identified that individuals from BAME communities face health inequalities and report poorer outcomes from numerous health interventions. This study will explore some of the reasons with a focus on the perceptions towards physical activity in the lifestyle prevention of diseases. It will also seek to elicit a range of facilitators and barriers towards improving physical activity lifestyle choices amongst UK BAME adults, including but not limited to those in the individual, structural, environmental and social domains. Furthermore, it will consider the role of ethnicity and culture in the forming of physical activity lifestyle choices. This study was conducted to explore the facilitators and inhibitors of making healthy physical activity lifestyle choices amongst UK BAME adults during the COVID-19 pandemic. The study will involve 2 phases: a systematic review and a qualitative study phase. The systematic review will be conducted using the PECO (Population, Exposure, Comparison, and Outcome) framework and the preferred reporting items for systematic reviews and meta-analyses (PRISMA) strategy. The qualitative study will be a semi-structured online personal interview of a purposive sample of 12 UK BAME adults residing in Teesside, North East of England (UK). The findings obtained would be useful in designing culturally relevant interventions that seek to improve physical activity lifestyle choices for UK BAME adults and inform future policy guidelines in the UK

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation